Impaired pre-competition wellbeing measures can negatively impact running performance in developmental youth female soccer players

This study aimed to determine the association between pre-competition perceived player wellbeing measures and subsequent relative and peak running performance of developmental youth female soccer players (n = 15, age: 16 ± 1 years). Total distance (TD), high-speed (&gt; 3.5 m/s) (HSRD) and very high-speed (&gt; 5.3 m/s) running (VHSRD) were expressed using 1-, 2- and 5-minute epochs and relative (per minute) calculations. Fatigue, sleep quality, upper and lower-body muscle soreness, stress, and mood wellbeing measures were collected via a self-reported questionnaire (1-5 Likert scale). Menstrual cycle phase was collected via a calendar-based countback method. Results demonstrated that reductions in stress was associated with decreased relative and peak TD in all epochs ( p = 0.008-0.040), relative and peak HSRD ( p = 0.006-0.039) in 2- and 5-minute epochs as well as VHSRD in 2-minute epochs ( p = 0.026). For example, a one-point reduction of 'normal' to 'relaxed' is associated with a decrease of 7 m/min in peak TD for 1-minute epochs. One-point increase in fatigue (e.g., 'normal' to 'more tired than normal') displayed a decrease of 7 m/min peak TD for 2-minute ( p = 0.048) and 9 m/min for 5-minute ( p = 0.007) rolling epochs. Likewise, one-point increase in lower-body muscle-soreness (e.g., 'normal' to 'increase in soreness/tightness') was associated with a reduction of 6 m/min peak VHSRD for 1-minute epochs ( p = 0.034). Results suggest that perceived player wellbeing can influence running performance. However, the magnitude of the change in player wellbeing should be considered in a practical sense. </p

Crop Updates 2003 - Cereals

This session covers twenty one papers from different authors: PLENARY 1. Recognising and responding to new market opportunities in the grains industry, Graham Crosbie, Manager, Grain Products Research, Crop Breeding, Plant Industries, Department of Agriculture 2. Stripe rust – where to now for the WA wheat industry? Robert Loughman1, Colin Wellings2 and Greg Shea11Department of Agriculture, 2University of Sydney Plant Breeding Institute, Cobbitty (on secondment from NSW Agriculture) 3. Benefits of a Grains Biosecurity Plan, Dr Simon McKirdy, Plant Health Australia, Mr Greg Shea, Department of Agriculture 4. Can we improve the drought tolerance of our crops? Neil C. Turner, CSIRO Plant Industry, Wembley 5. The silence of the lambing, Ross Kingwell, Department of Agriculture AGRONOMY AND VARIETIES 6. Maximising performance of wheat varieties, Brenda Shackley, Wal Anderson, Darshan Sharma, Mohammad Amjad, Steve Penny Jr, Melanie Kupsch, Anne Smith, Veronika Reck, Pam Burgess, Glenda Smith and Elizabeth Tierney, Department of Agriculture 7. Wheat variety performance in wet and dry, Peter Burgess 8. e-VarietyGuide for stripe rust – an updated version (1.02 – 2003), Moin Salam, Megan Collins, Art Diggle and Robert Loughman, Department of Agriculture 9. Baudin and Hamelin – new generation of malting barley developed in Western Australia, Blakely Paynter, Roslyn Jettner and Kevin Young, Department of Agriculture 10. Oaten hay production, Jocelyn Ball, Natasha Littlewood and Lucy Anderton, Department of Agriculture 11. Improving waterlogging tolerance in wheat and barley, Irene Waters and Tim Setter, Department of Agriculture 12. Broadscale variety comparisons featuring new wheat varieties, Jeff Russell, Department of Agriculture, Centre for Cropping Systems BIOTECHNOLOGY 13. Barley improvement in the Western Region – the intergration of biotechnologies, Reg Lance, Chengdao Li and Sue Broughton, Department of Agriculture 14. The Western Australian State Agricultural Biotechnology Centre – what we are and what we do, Michael Jones, WA State Agricultural Biotechnology Centre, Murdoch University 15. Protein and DNA methods for variety identification, Dr Grace Zawko, Saturn Biotech Limited 16. The Centre for High-throughput Agricultural Genetic Analysis (CHAGA), Keith Gregg, CHAGA, Murdoch University NUTRITION 17. Potassium – topdressed, drilled or banded? Stephen Loss, Patrick Gethin, Ryan Guthrie, Daniel Bell, Wesfarmers CSBP 18. Liquid phosphorus fertilisers in WA, Stephen Loss, Frank Ripper, Ryan Guthrie, Daniel Bell and Patrick Gethin, Wesfarmers CSBP 19. Wheat nutrition in the high rainfall cropping zone, Narelle Hill1and Laurence Carslake2, 1Department of Agriculture, 2Wesfarmers Landmark PESTS AND DISEASES 20. Managenent options for root lesion nematode in West Australian cropping systems, Vivien Vanstone, Sean Kelly and Helen Hunter, Department of Agriculture STORAGE 21. Aeration can profit your grain enterprise, Christopher R. Newman, Department of Agricultur

Crop Updates 2004 - Cereals

This session covers twenty eight papers from different authors: PLENARY 1. Declining profitability in continuous cropping systems. Is more wheat the answer on Duplex soil? Dr Wal Anderson, Department of Agriculture 2. Disease implications of extending the wheat phase in low-medium rainfall areas, Dr Vivian Vanstone and Dr Robert Loughman, Department of Agriculture 3. Prolonged wheat phase on duplex soils – where do weeds set the boundary? Vanessa Stewart, Department of Agriculture WHEAT AGRONOMY 4. Management of small grain screenings in wheat, Dr Wal Anderson and Dr Darshan Sharma, Department of Agriculture 5. Agronomic responses of new wheat varieties, Christine Zaicou-Kunesch, Dr Darshan Sharma, Brenda Shackley, Dr Mohammad Amjad, Dr Wal Anderson and Steve Penny,Department of Agriculture 6. Managing wheat yield reduction from wide rows, Dr Mohammad Amjad and Dr Wal Anderson, Department of Agriculture 7. Row spacing and stubble effect on wheat yield and ryegrass seed set, Glen Riethmuller, Department of Agriculture 8. Grain protein management – lessons learnt on the south coast, Jeremy Lemon, Department of Agriculture 9. Unravelling the mysteries of optimum seed rates, Dr Wal Anderson, Dr Darshan Sharma, Brenda Shackley and Mario D’Antuono, Department of Agriculture 10. Agronomic features for growing better wheat – south east agricultural region 2003, Dr Mohammad Amjad, Veronika Reck and Ben Curtis, Department of Agriculture 11. Agronomic responses of new wheat varieties – great southern agricultural region 2003, Brenda Shackley and Judith Devenish, Department of Agriculture 12. Variety specific responses of new wheat varieties – central agricultural region 2003, Dr Darshan Sharma and Dr Wal Anderson, Department of Agriculture 13. Agronomic responses of new wheat varieties – northern agricultural region 2003, Christine Zaicou-Kunesch, Melaine Kupsch and Anne Smith, Department of Agriculture BARLEY AND OAT AGRONOMY 14. Gairdner for high rainfall – where does Baudin fit in? Blakely Paynter, Roslyn Jettnerand Leanne Schulz, Department of Agriculture 15. Oaten hay – varieties and agronomy, Blakely Paynter, Jocelyn Ball and Tom Sweeny, Department of Agriculture NUTRITION 16. In-furrow fungicide applications in liquid fertiliser, Dr Stephen Loss, CSBP Ltd 17. Elemental sulphur as a fertiliser source in Western Australia, Ashleigh Brooks1A, Justin Fuery2, Geoff Anderson3 and Prof Zed Rengel1,1UWA, 2Summit FertilizerFertilisers and 3Department of Agriculture 18. Genetic variation in potassium efficiency of barley, Paul Damon and Prof. Zed Rengel, Faculty of Natural and Agricultural Sciences, UWA 19. Managing protein through strategic N applications, Eddy Pol and Dr Stephen Loss, CSBP Ltd 20. Nitrogen management for wheat in high rainfall cropping areas, Narelle Hill1, Ray Tugwell1, Dr Wal Anderson1, Ron McTaggart1and Nathan Moyes2, 1Department of Agriculture and 2Landmark 21. Flag smut resistance in current WA wheat varieties, John Majewski and Dr Manisha Shankar, Department of Agriculture 22. Rust resistance update for wheat varieties in WA, Dr Manisha Shankar, John Majewski and Jamie Piotrowski, Department of Agriculture PESTS AND DISEASES 23. Stripe rust in WA – where was it and what can we learn from 2003? Dr Robert Loughman and Ciara Beard, Department of Agriculture 24. Foliar disease management – a key factor in the adoption of Baudin and Hamlin barley, Dr Kithsiri Jayasena, Dr Rob Loughman, Kazue Tanaka and Grey Poulish, Department of Agriculture 25. Validating aphid and virus risk forecasts for cereals, Dr Debbie Thackray, Rohan Prince and Dr Roger Jones, Department of Agriculture and Centre for Legumes in Mediterranean Agriculture HARVESTING 26. Swathing Gairdner barley at 30% moisture, Peter Nelson¹ and Nigel Metz², ¹Cooperative Bulk Handling and ² Fitzgerald Biosphere Group MODELLING 27. Development of a web based grower decision aid application for cereal growers, Dr Leisa Armstrong1, Yee Leong (Alex) Yung1and Dr Moin Salam2 1School of Computer and Information Science, Edith Cowan University; and 2Department of Agriculture 28. Wheat varieties updated in ‘Flowering Calculator’ – a model predicting flowering time, Brenda Shackley, Dr David Tennant, Dr Darshan Sharma and Christine Zaicou‑Kunesch, Department of Agricultur

Crop Updates 2003 - -Katanning

This session covers sixteen papers from different authors Breeding Cereals for Rust Resistance – are we losing the battle? Robert F. Park, University of Sydney Stripe rust – where to now for the WA wheat industry? Robert Loughman, Department of Agriculture, Colin Wellings, University of Sydney, Greg Shea, Department of Agriculture Oaten hay production, Jocelyn Ball, Natasha Littlewood and Lucy Creagh, Department of Agriculture Don’t rely on ‘Spray and Pray’ Alex Douglas, Department of Agriculture Seasonal outlook: What is in store for 2003, David Stephens, Department of Agriculture No-till copper, phosphorus and zinc experiments, Ross Brennan and Mike Bolland, Department of Agriculture Wheat nutrition in the high rainfall zone, Narelle Hill, Department of Agriculture Aphid damage to cereal grain crops, Phil Michael, Department of Agriculture Aphid damage to canola – not all cultivars are equal, Francoise A. Berlandier and Christiaan Valentine, Department of Agriculture Overcropping Lucerne, Roy Latta, Department of Agriculture Future direction of field pea varieties, M. Rodger Beermier, Department of Agriculture Selecting the right pasture for the job, Keith Devenish, Department of Agriculture Topping up pasture seedbanks, Keith Devenish, Department of Agriculture Baudin and Hamlin New generation of malting barleys, Blakely Paynter, Roslyn Jettner and Kevin Young, Department of Agriculture Wheat variety performance in 2002 compared to the long term, Robin Wilson, Ian Barclay Robyn McLean, Robert Loughman, Jenny Garlinge, Bill Lambe, Neil Venn and Peter Clarke, Department of Agriculture The role of green manure crops in renovating poor performing paddocks: What’s it worth? Francis Hoyle, Leanne Schulz and Judith Devenish, Department of Agricultur

HER2-enriched subtype and novel molecular subgroups drive aromatase inhibitor resistance and an increased risk of relapse in early ER+/HER2+ breast cancer

BACKGROUND: Oestrogen receptor positive/ human epidermal growth factor receptor positive (ER+/HER2+) breast cancers (BCs) are less responsive to endocrine therapy than ER+/HER2- tumours. Mechanisms underpinning the differential behaviour of ER+HER2+ tumours are poorly characterised. Our aim was to identify biomarkers of response to 2 weeks’ presurgical AI treatment in ER+/HER2+ BCs. METHODS: All available ER+/HER2+ BC baseline tumours (n=342) in the POETIC trial were gene expression profiled using BC360™ (NanoString) covering intrinsic subtypes and 46 key biological signatures. Early response to AI was assessed by changes in Ki67 expression and residual Ki67 at 2 weeks (Ki672wk). Time-To-Recurrence (TTR) was estimated using Kaplan-Meier methods and Cox models adjusted for standard clinicopathological variables. New molecular subgroups (MS) were identified using consensus clustering. FINDINGS: HER2-enriched (HER2-E) subtype BCs (44.7% of the total) showed poorer Ki67 response and higher Ki672wk (p<0.0001) than non-HER2-E BCs. High expression of ERBB2 expression, homologous recombination deficiency (HRD) and TP53 mutational score were associated with poor response and immune-related signatures with High Ki672wk. Five new MS that were associated with differential response to AI were identified. HER2-E had significantly poorer TTR compared to Luminal BCs (HR 2.55, 95% CI 1.14–5.69; p=0.0222). The new MS were independent predictors of TTR, adding significant value beyond intrinsic subtypes. INTERPRETATION: Our results show HER2-E as a standardised biomarker associated with poor response to AI and worse outcome in ER+/HER2+. HRD, TP53 mutational score and immune-tumour tolerance are predictive biomarkers for poor response to AI. Lastly, novel MS identify additional non-HER2-E tumours not responding to AI with an increased risk of relapse

Periodization and physical performance in elite female soccer players

Purpose:To investigate the variation in training demands, physical performance, and player well-being across a women’s soccer season.Methods:Seventeen elite female players wore GPS tracking devices during every training session (N = 90) throughout 1 national-league season. Intermittent high-speed-running capacity and 5-, 15-, and 25-m-sprint testing were conducted at the beginning of preseason, end of preseason, midseason, and end of season. In addition, subjective well-being measures were selfreported daily by players over the course of the season.Results:Time over 5 m was lowest at the end of preseason (mean 1.148 s, SE 0.017 s) but then progressively deteriorated to the end of the season (P &lt; .001). Sprint performance over 15 m improved by 2.8% (P = .013) after preseason training, while 25-m-sprint performance peaked at midseason, with a 3.1% (P = .05) improvement from the start of preseason, before declining at the end of season (P = .023). Training demands varied between phases, with total distance and high-speed distance greatest during preseason before decreasing (P &lt; .001) during the early- and late-season phases. Endurance capacity and well-being measures did not change across training phases.Conclusions:Monitoring training demands and subsequent physical performance in elite female soccer players allow coaches to ensure that training periodization goals are being met and related positive training adaptations are being elicited.</jats:sec

Substitute running outputs in elite youth male soccer players: less peak but greater relative running outputs

Coaches consider substitute players to be a substantial factor in influencing the outcome of a soccer match. Substitute players are expected to make physical impact on the match by superseding the running output of the player they replaced and are a key tool for managing in-game fatigue and influencing the outcome of a game. This study investigated the physical impact and internal response of substitute players, compared to starting and full-match players. We also sought to determine if differences between substitution statuses were influenced by playing position. Players wore 15-Hz global positioning system tracking devices across 29 competition matches and were categorised according to their substitution status (full-match, starters, substitutes) and playing position (external defender, midfield, external attacker and central attacker). Peak total (TD) and high-speed running (> 5.0 m/s) distance (HSRD) were calculated using 1-, 2- and 5-minute rolling epochs. Relative running demands were reported as TD and HSRD per minute of total playing time. Substitute players performed less peak TD and HSRD in 1-, 2- and 5-minute epochs, and reported lower RPE compared to starting and full-match players. In contrast, substitutes performed greater relative HSRD per minute than starting and full-match players (p < 0.001, |d| range = 0.35–1.34). In conclusion, substitute players may have a relative physical impact but do not replicate or supersede the peak demands of full-match players. Coaches and practitioners should implement targeted warm-up interventions to enhance substitute readiness to meet the peak running demands in order to have a more effective physical impact