A Kikuchi-Fujimoto Disease Case Mimicking T Cell Lymphoma with Prolonged Fever

Kikuchi-Fujimoto disease (KFD) is a self-limited disease characterized by necrotizing lymphadenitis. Although cervical lymphadenitis in young women is the most familiar clinical presentation, it may take place in the etiology of fever in cases presenting with fever of unknown origin. A 33-year-old male case admitted with fever, nausea, vomiting, weight loss, and leukopenia for one month, subsequently developing axillary lymphadenopathy during followup, diagnosed as KFD with typical histopathological findings, and showing full recovery after the excision of lymph node was presented in this report

Current and Future Therapies for Hepatitis C Virus Infection

To the Editor: In their review of drug therapy for chronic hepatitis C infection, Liang and Ghany (May 16 issue)(1) summarize boceprevir- and telaprevir-based regimens. Figure 2 of the article describes the regimens according to the response to the previous therapy, the response-guided therapy, and the stopping rules. The boceprevir regimen they describe represents the labeling information in the United States.(2) However, the information about boceprevir in European regimens has some differences(3) the duration of therapy for patients who have not had a response to previous therapy (whether the patient had a relapse, a partial response, or no response) ..

More on hepatic granulomas

We have read the case report of Nihon-Yanagi et al. The patient they described developed hepatic granuloma two times and the granulomatous lesion was surrounding metal staples/clips suggesting that the granuloma was due to surgical staples/clips

Epidemiology of HBV subgenotypes D

The natural history of hepatitis B virus infection is not uniform and affected from several factors including, HBV genotype. Genotype D is a widely distributed genotype. Among genotype D, several subgenotypes differentiate epidemiologically and probably clinically. D1 is predominant in Middle East and North Africa, and characterized by early HBeAg seroconversion and low viral load. D2 is seen in Albania, Turkey, Brazil, western India, Lebanon, and Serbia. D3 was reported from Serbia, western India, and Indonesia. It is a predominant subgenotype in injection drug use-related acute HBV infections in Europe and Canada. D4 is relatively rare and reported from Haiti, Russia and Baltic region, Brazil, Kenya, Morocco and Rwanda. Subgenotype D5 seems to be common in Eastern India. D6 has been reported as a rare subgenotype from Indonesia, Kenya, Russia and Baltic region. D7 is the main genotype in Morocco and Tunisia. D8 and D9 are recently described subgenotypes and reported from Niger and India, respectively. Subgenotypes of genotype D may have clinical and/or viral differences. More subgenotype studies are required to conclude on subgenotype and its clinical/viral characteristics. (C) 2014 Elsevier Masson SAS. All rights reserved