For an Ecological Music – Max Neuhaus

Silence is static whereas sounds, noises and smells are dynamic. It was Carlo Carrà who declared as much, in 1913, reckoning that the moment had come for painting, that art of silence, to leave its hieratic space and launch itself into the conquest of modern society’s speeded-up space/time-frames. The pictorial languages must henceforth be capable of expressing a “plastic equivalent” of the variety of sensory stimulations offered by the modern city, with its “theatres, music-halls, cinemas, b..

Pour une musique écologique – Max Neuhaus

Le silence est statique alors que les sons, bruits et odeurs sont dynamiques. C’est Carlo Carrà qui l’affirme en 1913, en estimant que le moment est arrivé pour la peinture, cet art du silence, de quitter son espace hiératique pour se lancer à la conquête des espace-temps accélérés de la société moderne. Le langage pictural doit dès lors être capable d’exprimer un « équivalent plastique » de la variété des stimulations sensorielles offertes par la ville moderne, avec ses « théâtres, salles de..

PENGARUH PENGUNGKAPAN CORPORATE SOCIAL RESPOSIBILITY DAN INTELLECTUAL CAPITAL TERHADAP NILAI PERUSAHAAN DENGAN KINERJA KEUANGAN SEBAGAI MODERASI

Penelitian ini dilakukan dengan tujuan untuk mengetahui pengaruh pengungkapan corporate social resposibility dan intellectual capital terhadap nilai perusahaan dengan kinerja keuangan sebagai moderasi. Metode purposive sampling digunakan sebagai teknik pengambilan sampel dengan 49 perusahaan terpilih dari seluruh perusahaan non keuangan terdaftar di Bursa Efek Indonesia dan telah menggunakan standar Global Reproting Initiative (GRI) sebagai pedoman laporan keberlanjutannya pada tahun 2020-2021. Penelitian ini menggunakan sumber data sekunder yang berasal dari laporan tahunan dan laporan keberlanjutan perusahaan. Adapun teknik analisis data yang digunakan adalah teknik regresi linear berganda dengan menggunakan software SPSS versi 26. Hasil penelitian ini membuktikan bahwa pengungkapan corporate social responsibility berpengaruh positif dan signifikan terhadap nilai perusahaan dikarenakan kehadiran perusahaan diterima oleh masyarakat sekitar dan memiliki keberlangsungan usaha yang terjamin sehingga nilai milik perusahaan akan meningkat. Intellectual capital berpengaruh positif signifikan terhadap nilai perusahaan dikarenakan perusahaan memiliki keunggulan kompetitif yang memampukan perusahaan untuk bersaing dan memiliki prosperk menguntungkan di masa depan yang kemudian akan menarik minat investor sehingga nilai perusahaan akan meningkat. Kinerja keuangan tidak mampu memoderasi pengaruh pengungkapan corporate social responsibility terhadap nilai perusahaan dikarenakan apapun kondisi keuangannya, perusahaan harus tetap bertanggung jawab secara optimal atas dampak negatif yang ditimbulkan. Kinerja keuangan mampu memoderasi pengaruh intellectual capital terhadap nilai perusahaan dikarenakan perusahaan memiliki keunggulan kompetitif yang dapat menjadi modal dalam persaingan bisnis dan dengan kinerja keuangan yang tinggi akan menjamin keberlangsungan operasional perusahaan sehingga perusahaan dinilai lebih oleh pasar. Kata Kunci : Nilai Perusahaan, Pengungkapan Corporate Social Responsibility, Intellectual Capital, Kinerja Keuangan *** This study was conducted with the aim of determining the effect of disclosure of corporate social responsibility and intellectual capital on firm value with financial performance as moderation. The purposive sampling method was used as a sampling technique with 49 companies selected from all non-financial companies listed on the Indonesia Stock Exchange and have used Global Reproting Initiative (GRI) standards as guidelines for their sustainability reports in 2020-2021. This study uses secondary data sources derived from annual reports and corporate sustainability reports. The data analysis technique used is multiple linear regression technique using SPSS version 26 software. The results of this study prove that corporate social responsibility disclosure has a positive and significant effect on firm value because the company's presence is accepted by the surrounding community and has guaranteed business continuity so that the value of the company will increase. Intellectual capital has a significant positive effect on firm value because the company has a competitive advantage that enables the company to compete and has profitable prosperity in the future which will then attract investor interest so that the company's value will increase. Financial performance is unable to moderate the effect of corporate social responsibility disclosure on firm value because whatever the financial condition, the company must remain optimally responsible for the negative impacts caused. Financial performance is able to moderate the effect of intellectual capital on firm value because the company has a competitive advantage that can become capital in business competition and with high financial performance will ensure the sustainability of the company's operations so that the company is valued more by the market. Keywords: Firm Value, Corporate Social Responsibility Disclosure, Intellectual Capital, Financial Performance

Integrating Animation Artists into the Animation Design of Social Robots: An Open-Source Robot Animation Software

International audienceMovements are an important part of robot design and we need dedicated tools to design them. As previous research has shown, 3D animation techniques are of great use to animate a robot. However, most robots don't benefit from an animation tool and therefore from animation artists knowledge. We present an open-source robot animation software to address this issue and describe some principles for designing a robot animation software derived from the specificity of robot as a medium

Funnel-web spider bite: a systematic review of recorded clinical cases

The document attached has been archived with permission from the editor of the Medical Journal of Australia (09 January 2008). An external link to the publisher’s copy is included.Objective: To investigate species-specific envenoming rates and spectrum of severity of funnel-web spider bites, and the efficacy and adverse effects of funnel-web spider antivenom. Data sources: Cases were identified from a prospective study of spider bite presenting to four major hospitals and three state poisons information centres (1999–2003); museum records of spider specimens since 1926; NSW Poisons Information Centre database; MEDLINE and EMBASE search; clinical toxinology textbooks; the media; and the manufacturer’s reports of antivenom use. Data extraction: Patient age and sex, geographical location, month, expert identification of the spider, clinical effects and management; envenoming was classified as severe, mild–moderate or minor/local effects. Data synthesis: 198 potential funnel-web spider bites were identified: 138 were definite (spider expertly identified to species or genus), and 77 produced severe envenoming. All species-identified severe cases were attributed to one of six species restricted to NSW and southern Queensland. Rates of severe envenoming were: Hadronyche cerberea (75%), H. formidabilis (63%), Atrax robustus (17%), Hadronyche sp. 14 (17%), H. infensa (14%) and H. versuta (11%). Antivenom was used in 75 patients, including 22 children (median dose, 3 ampoules; range, 1–17), with a complete response in 97% of expertly identified cases. Three adverse reactions were reported, all in adults: two early allergic reactions (one mild and one with severe systemic effects requiring adrenaline), and one case of serum sickness. Conclusions: Severe funnel-web spider envenoming is confined to NSW and southern Queensland; tree-dwelling funnel webs (H. cerberea and H. formidabilis) have the highest envenoming rates. Funnel-web spider antivenom appears effective and safe; severe allergic reactions are uncommon.Geoffrey K Isbister, Michael R Gray, Corrine R Balit, Robert J Raven, Barrie J Stokes, Kate Porges, Alan S Tankel, Elizabeth Turner, Julian White and Malcolm McD Fishe

Fostering Social Change in Peru Through Communication: The Case of the Manuani Miners Association

Much has been done to formalize miners in Peru; since its inception in 2006 the Ministry of Environment passed laws to align mining policies with international standards. However, the combination of the necessity to have a source of income and the rapid acquisition of money that illegal and informal gold mining provides has proven a serious impasse for the Peruvian government; hence these mining practices keep growing. As part of the Initiative for the Conservation of the Andean Amazon II (ICAA II), the Manuani Miners Association in Madre de Dios, one of the regions more prone to illegal mining and bad environmental practices in Peru, started a land restoration, remediation, and reforestation process of the degraded rainforest. This case study analyzes how a program within ICAA II used communication to promote this significant change in behavior, what communicational tools were used, and what is their possible further applicability in similar scenarios to foster positive change

Convulsive liability of bupropion hydrochloride metabolites in Swiss albino mice

<p>Abstract</p> <p>Background</p> <p>It is known that following chronic dosing with bupropion HCl active metabolites are present in plasma at levels that are several times higher than that of the parent drug, but the possible convulsive effects of the major metabolites are not known.</p> <p>Methods</p> <p>We investigated the convulsive liability and dose-response of the three major bupropion metabolites following intraperitoneal administration of single doses in female Swiss albino mice, namely erythrohydrobupropion HCl, threohydrobupropion HCl, and hydroxybupropion HCl. We compared these to bupropion HCl. The actual doses of the metabolites administered to mice (n = 120; 10 per dose group) were equimolar equivalents of bupropion HCl 25, 50 and 75 mg/kg. Post treatment, all animals were observed continuously for 2 h during which the number, time of onset, duration and intensity of convulsions were recorded. The primary outcome variable was the percentage of mice in each group who had a convulsion at each dose. Other outcome measures were the time to onset of convulsions, mean convulsions per mouse, and the duration and intensity of convulsions.</p> <p>Results</p> <p>All metabolites were associated with a greater percentage of seizures compared to bupropion, but the percentage of convulsions differed between metabolites. Hydroxybupropion HCl treatment induced the largest percentage of convulsing mice (100% at both 50 and 75 mg/kg) followed by threohydrobupropion HCl (50% and 100%), and then erythrohydrobupropion HCl (10% and 90%), compared to bupropion HCl (0% and 10%). Probit analysis also revealed the dose-response curves were significantly different (p < 0.0001) with CD₅₀values of 35, 50, 61 and 82 mg/kg, respectively for the four different treatments. Cox proportional hazards model results showed that bupropion HCl, erythrohydrobupropion HCl, and threohydrobupropion HCl were significantly less likely to induce convulsions within the 2-h post treatment observation period compared to hydroxybupropion HCl. The mean convulsions per mouse also showed the same dose-dependent and metabolite-dependent trends.</p> <p>Conclusion</p> <p>The demonstration of the dose-dependent and metabolite-dependent convulsive effects of bupropion metabolites is a novelty.</p

Alcohol significantly lowers the seizure threshold in mice when co-administered with bupropion hydrochloride

<p>Abstract</p> <p>Background</p> <p>Bupropion HCl is a widely used antidepressant that is known to cause seizures in a dose-dependent manner. Many patients taking antidepressants will consume alcohol, even when advised not to. Previous studies have not shown any interactions between bupropion HCl and alcohol. However, there have been no previous studies examining possible changes in seizure threshold induced by a combination of alcohol and bupropion HCl.</p> <p>Methods</p> <p>Experimentally naïve female Swiss albino mice (10 per group) received either single doses of bupropion HCl (ranging from 100 mg/kg to 120 mg/kg) or vehicle (0.9% NaCl) by intraperitoneal (IP) injection in a dose volume of 10 ml/kg, and single-dose ethanol alone (2.5 g/kg), or vehicle, 5 min prior to bupropion dosing. The presence or absence of seizures, the number of seizures, the onset, duration and the intensity of seizures were all recorded for 5 h following the administration of ethanol.</p> <p>Results</p> <p>The results show that administration of IP bupropion HCl alone induced seizures in mice in a dose-dependent manner, with the 120 mg/kg dose having the largest effect. The percentage of convulsing mice were 0%, 20%, 30% and 60% in the 0 (vehicle), 100, 110, and 120 mg/kg dose groups, respectively. Pretreatment with ethanol produced a larger bupropion HCl-induced convulsive effect at all the doses (70% each at 100, 110 and 120 mg/kg) and a 10% effect in the ethanol + vehicle only group. The convulsive dose of bupropion HCl required to induce seizures in 50% of mice (CD₅₀), was 116.72 mg/kg for bupropion HCl alone (CI: 107.95, 126.20) and 89.40 mg/kg for ethanol/bupropion HCl (CI: 64.92, 123.10).</p> <p>Conclusion</p> <p>These results show that in mice alcohol lowers the seizure threshold for bupropion-induced seizures. Clinical implications are firstly that there may be an increased risk of seizures in patients consuming alcohol, and secondly that formulations that can release bupropion more readily in alcohol may present additional risks to patients.</p