Effect of an acute β-adrenergic blockade on exercise intensity corresponding to the lactate minimum

β-Adrenoreceptor blockade is reported to impair endurance, power output and work capacity in healthy subjects and patients with hypertension. The purpose of this study was to investigate the effect in eighth athletic males of an acute β-adrenergic blockade with propranolol on their individual power output corresponding to a defined lactate minimum (LM). Eight fit males (cyclist or triathlete) performed a protocol to determine the power output corresponding to their individual LM (defined from an incremental exercise test after a rapidly induced exercise lactic acidosis). This protocol was performed twice in a double-blind randomized order by each athlete first ingesting propranolol (80mg) and in a second trial a placebo, 120 minutes respectively prior to the test sequence. The blood lactate concentration obtained 7 minutes after anaerobic exercise (a Wingate test) was significantly lower after acute β-adrenergic blockade (8.6 ± 1.6mM) than under the placebo condition (11.7 ± 1.6mM). The work rate at the LM was lowered from 215.0 ± 18.6 to 184.0 ± 18.6 watts and heart rate at the LM was reduced from 165 ± 1.5 to 132 ± 2.2 beats/minute as a result of the blockade. There was a non-significant correlation (r = 0.29) between the power output at the LM with and without acute β-adrenergic blockade. In conclusion, since the intensity corresponding to the LM is related to aerobic performance, the results of the present study, are able to explain in part, the reduction in aerobic power output produced during β-adrenergic blockade

Análise das velocidades: referencial de 4mM, de equilíbrio de 30 min e velocidade crítica em nadadoras adolescentes Velocities analysis: 4 mM reference, 30 min steady-state and critical velocity in female adolescent swimmers

OBJETIVO: Comparar os resultados do cálculo da velocidade de limiar anaeróbio (Lan), correspondente a 4mM de lactato, obtidos em testes de 2 x 400m (V4-2), 4 x 400m (V4-4) e a velocidade crítica (VC) relacionando-as com a velocidade média determinada no teste de 30 min (VMT30) em nadadoras adolescentes. METODOLOGIA: Participaram deste estudo 20 nadadoras (14,36 ± 1,22 anos; 52,75 ± 5,32kg; 159,97 ± 11,26cm; 22,5 ± 4,73% gordura corporal) de nível regional e estadual com pelo menos dois anos de treinamento sistemático. Testes realizados: Teste de 30 min (VMT30), Teste de duas distâncias (V4-2), Teste de quatro distâncias (V4-4) e Velocidade Crítica (VC). Análise estatística: o procedimento adotado para a comparação de todas as metodologias, duas a duas, foi a técnica de análise de regressão simples. RESULTADOS: As velocidades médias dos testes foram: VMT30: 1,12 ± 0,06m/s; V4-2: 1,14 ± 0,12m/s; V4-4: 1,12 ± 0,06m/s e a VC média: 1,14 ± 0,07m/s. Análise de regressão simples entre as metodologias duas a duas: V4-4 e V4-2 (r = 0,324), VC e V4-2 (r = 0,058), VMT30 e V4-2 (r = 0,595), VC e V4-4 (r = 0,807), VMT30 e V4-4 (r = 0,796) e VMT30 e VC (r = 0,677). As retas de regressão ajustadas apresentaram em relação à bissetriz os valores de p = 0,3060; 0,1716 e 0,0058. CONCLUSÕES: A determinação da VMT30 constitui-se em um bom instrumento para a prescrição de treinamento para as nadadoras estudadas, o que nem sempre ocorre com o modelo V4-2; a [La] de 4mM com quatro pontos e o cálculo do limiar de lactato através da técnica de efeitos aleatórios, mostrou-se viável para a determinação do Lan para as nadadoras, quando comparada com a VMT30; a VC e V4-4 apresentaram boa correlação assim como a VC e VMT30.<br>OBJECTIVE: To compare the results of the calculation of the anaerobic threshold velocity (AT), corresponding to 4 mM lactate, obtained in 2 x 400 m (V4-2), 4 x 400 m (V4-4) tests and critical velocity (CV) relating to the mean velocity determined in the 30 min test (VMT30) in female adolescent swimmers. METHODS: Twenty female swimmers (14.36 ± 1.22 years old; 52.75 ± 5.32 kg ; 159.97 ± 11.26 cm; % body fat 22.5 ± 4.73),with city and state level with at least two years of sistematic training participated in this study. Performed tests: 30 min test (MVT30), two-distance test (V4-2), four-distance test (V4-4) and critical velocity (CV). Statistical analysis: the procedure adopted to compare all methodologies, two by two, was the single regression analysis technique. RESULTS: The mean velocities were: T30: 1.12 ± 0.06 m/s; V4-2: 1.14 ± 0.12 m/s; V4-4: 1.12 ± 0.06 m/s and CV mean = 1.14 ± 0.07 m/s. Single regression analysis between metodologies, two by two: V4-4 and V4-2 (r = 0.324); CVand V4-2 (r = 0,058); MVT30 and V4-2 (r = 0.595); CV and V4-4 (r = 0.807); MVT30 and V4-4 (r = 0,796) and MVT30 and CV (r = 0,77). The adjusted regression lines presented in relation to the bisectrix the values of p = 0.3060; 0.1716 and 0.0058. CONCLUSIONS: The VMT30 determination is a good instrument for training prescription for the female adolescent swimmers studied, unlike the V4-2 model. The 4mM [La] with four points and lactate threshold calculation using random effects technique was useful for the AT determination in female adolescent swimmers, when compared to the MVT30; the CV and V4-4 presented a good correlation as well as the CV and MVT30