1,393 research outputs found

    Level Set Approach to Reversible Epitaxial Growth

    Full text link
    We generalize the level set approach to model epitaxial growth to include thermal detachment of atoms from island edges. This means that islands do not always grow and island dissociation can occur. We make no assumptions about a critical nucleus. Excellent quantitative agreement is obtained with kinetic Monte Carlo simulations for island densities and island size distributions in the submonolayer regime.Comment: 7 pages, 9 figure

    Translocator protein in late stage Alzheimer\u27s disease and Dementia with Lewy bodies brains

    Get PDF
    OBJECTIVE: Increased translocator protein (TSPO), previously known as the peripheral benzodiazepine receptor (PBR), in glial cells of the brain has been used as a neuroinflammation marker in the early and middle stages of neurodegenerative diseases, such as Alzheimer\u27s disease (AD) and Dementia with Lewy Bodies (DLB). In this study, we investigated the changes in TSPO density with respect to late stage AD and DLB. METHODS: TSPO density was measured in multiple regions of postmortem human brains in 20 different cases: seven late stage AD cases (Braak amyloid average: C; Braak tangle average: VI; Aged 74-88, mean: 83 ± 5 years), five DLB cases (Braak amyloid average: C; Braak tangle average: V; Aged 79-91, mean: 84 ± 4 years), and eight age-matched normal control cases (3 males, 5 females: aged 77-92 years; mean: 87 ± 6 years). Measurements were taken by quantitative autoradiography using [ RESULTS: No significant changes were found in TSPO density of the frontal cortex, striatum, thalamus, or red nucleus of the AD and DLB brains. A significant reduction in TSPO density was found in the substantia nigra (SN) of the AD and DLB brains compared to that of age-matched healthy controls. INTERPRETATION: This distinct pattern of TSPO density change in late stage AD and DLB cases may imply the occurrence of microglia dystrophy in late stage neurodegeneration. Furthermore, TSPO may not only be a microglia activation marker in early stage AD and DLB, but TSPO may also be used to monitor microglia dysfunction in the late stage of these diseases

    Specific association between the human DNA repair proteins XPA and ERCC1.

    Full text link

    Mass-Transport Models with Multiple-Chipping Processes

    Get PDF
    We study mass-transport models with multiple-chipping processes. The rates of these processes are dependent on the chip size and mass of the fragmenting site. In this context, we consider k-chip moves (where k = 1, 2, 3, ....); and combinations of 1-chip, 2-chip and 3-chip moves. The corresponding mean-field (MF) equations are solved to obtain the steady-state probability distributions, P (m) vs. m. We also undertake Monte Carlo (MC) simulations of these models. The MC results are in excellent agreement with the corresponding MF results, demonstrating that MF theory is exact for these models.Comment: 18 pages, 4 figures, To appear in European Physical Journal

    The effect of monomer evaporation on a simple model of submonolayer growth

    Full text link
    We present a model for thin film growth by particle deposition that takes into account the possible evaporation of the particles deposited on the surface. Our model focuses on the formation of two-dimensional structures. We find that the presence of evaporation can dramatically affect the growth kinetics of the film, and can give rise to regimes characterized by different ``growth'' exponents and island size distributions. Our results are obtained by extensive computer simulations as well as through a simple scaling approach and the analysis of rate equations describing the system. We carefully discuss the relationship of our model with previous studies by Venables and Stoyanov of the same physical situation, and we show that our analysis is more general.Comment: 41 pages including figures, Revtex, to be published in Physical Review

    Droplet Fluctuations in the Morphology and Kinetics of Martensites

    Full text link
    We derive a coarse grained, free-energy functional which describes droplet configurations arising on nucleation of a product crystal within a parent. This involves a new `slow' vacancy mode that lives at the parent-product interface. A mode-coupling theory suggests that a {\it slow} quench from the parent phase produces an equilibrium product, while a {\it fast} quench produces a metastable martensite. In two dimensions, the martensite nuclei grow as `lens-shaped' strips having alternating twin domains, with well-defined front velocities. Several empirically known structural and kinetic relations drop out naturally from our theory.Comment: 4 pages, REVTEX, and 3 .eps figures, compressed and uuencoded, Submitted to Phys. Rev. Let

    A Hybrid Monte Carlo Method for Surface Growth Simulations

    Full text link
    We introduce an algorithm for treating growth on surfaces which combines important features of continuum methods (such as the level-set method) and Kinetic Monte Carlo (KMC) simulations. We treat the motion of adatoms in continuum theory, but attach them to islands one atom at a time. The technique is borrowed from the Dielectric Breakdown Model. Our method allows us to give a realistic account of fluctuations in island shape, which is lacking in deterministic continuum treatments and which is an important physical effect. Our method should be most important for problems close to equilibrium where KMC becomes impractically slow.Comment: 4 pages, 5 figure

    Remote sensing of fish-processing in the Sundarbans Reserve Forest, Bangladesh: an insight into the modern slavery-environment nexus in the coastal fringe

    Get PDF
    © 2020, The Author(s). Land-based fish-processing activities in coastal fringe areas and their social-ecological impacts have often been overlooked by marine scientists and antislavery groups. Using remote sensing methods, the location and impacts of fish-processing activities were assessed within a case study of Bangladesh’s Sundarbans mangrove forests. Ten fish-processing camps were identified, with some occurring in locations where human activity is banned. Environmental degradation included the removal of mangroves, erosion, and the destruction of protected areas. Previous studies have identified cases of labour exploitation and modern slavery occurring within the Sundarbans, and remote sensing was used to triangulate these claims by providing spatial and temporal analysis to increase the understanding of the operational trends at these locations. These findings were linked to the cyclical relationship between modern slavery and environmental degradation, whereby environmental damage is both a driver and result of workers subjected to modern slavery. Remote sensing can be used as an additional methodological tool to support the achievement of the Sustainable Development Goals (SDGs) and provide evidence to support the promotion of the “freedom dividend” which would have far-reaching economic, social, cultural, and environmental benefits. Satellite remote sensing is likely to play an important role going forward for understanding these issues but should be augmented with ground-based data collection methods
    corecore