Kaplan-Meier curves for the OS of clinical variables of metastatic SCLC patients.

<p>(A) age <70 yrs vs. ≥70yrs (p = 0.001), (B) ECOG PS 0–1 vs. ECOG PS >1 (p<0.001), (C) male (vs. female; p = 0.021), and (D) radiation therapy (RT) vs. patients not treated with RT (p<0.001).</p

Kaplan-Meier curves for the OS of metastatic SCLC patients. Effect of FDA approved drugs.

<p>(A) Aspirin (vs. control; p = 0.225), (B) doxazosin and prazosin (vs. control; p<0.479), (C) selective serotonin reuptake inhibitors (SSRIs) (vs. control; p = 0.195), (D) statin treatment vs. control (p = 0.002) and, (E) clomipramine (a tricyclic antidepressant; TCA) vs. control had no effect on OS.</p

MNWS and ZSDS scores and CO levels of the three phenotypic clusters (C1, C2, C3) identified by two-step cluster analysis.

<p>MNWS, Minnesota Nicotine Withdrawal Scale; ZSDS, Zung Self-Rating Depression Scale; SD, standard deviation.</p

Linkage disequilibrium map of the seven investigated SNPs.

<p>1 = rs4522666, 2 = rs6090378, 3 = rs3787138; 4 = rs1044396; 5 = rs3787140, 6 = rs2093107, 7 = rs755203.</p

Frequencies of different haplotypes in phenotypic clusters.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. ^achi-square test indicated a significantly higher frequency of GCC haplotype in C3 compared to non-C3 clusters.</p

Results of risk analysis of haplotype carrying in different phenotypic clusters.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. OR, odds ratio.</p

Haplotype association tests on C3 phenotypic cluster in GLM and HapScore tests.

<p>Allelic components of the presented haplotypes are rs3787138, rs1044396 and rs3787140 SNPs, respectively. ^a<i>p_model = 0.018</i>; GLM, general linear model.</p

Descriptive characteristics of the study population.

<p>FTND, Fagerström Test for Nicotine Dependence; MNWS, Minnesota Nicotine Withdrawal Scale; COPD, chronic obstructive pulmonary disorder; ZSDS, Zung Self-Rating Depression Scale; SD, standard deviation; MDD, major depressive disorder.</p

Two-step cluster analysis of three phenotypic variables resulted in three significantly different clusters.

<p>Mean scores are represented as percentages of possible maximum points for each measurements. MNWS, Minnesota Nicotine Withdrawal Scale; ZSDS, Zung Self-Rating Depression Scale.</p

BARD1 protein structure and epitopes.

<p>The top line shows FL BARD1 exon structure is shown with protein motives RING, Ankyrin (ANK) repeats, and BRCT domains indicated. Grey lines underneath show BARD1 isoforms with dotted lines representing the respective missing exons. Brown bars on the bottom represent protein fragments used for ELISA experiments.</p