6,823 research outputs found
In silico Protein Structural Modeling and Active binding site Evaluation of Streptococcus pneumoniae
Structure function relation of glucose kinese in Streptococcus pneumoniae. However, a solved structure for _Streptococcus pneumoniae_ glucose kinese is not available at the protein data bank. Glucose kinase is a regulatory enzyme capable of adding phosphate group to glucose in the first step of streptomycin biosynthesis. The activity of glucose kinase was regulated by the Carbon Catabolite Repression system. So, we created a model of glucose kinese from _Streptococcus pnemoniae_ using the X-ray crystallography structure of glucose kinese enzymes from _Enterobacteria faecalis_ as template with Molsoft ICM v3.5 software. The model was validated using protein structure checking tools such as PROCHECK, WHAT IF: for reliability. The active site amino acid "Asp114" in the template is retained in _S. pneumoniae_ Glucose kinese model "Asp115". Solvent accessible surface area analysis of the glucose kinese model showed that known key residues playing important role in active site for ligand binding and metal ion binding are buried and hence not accessible to solvent. The information thus discussed provides insight to the molecular understanding of _Streptococcus pneumoniae_ in glucose kinase
Constrained Stabilization of Discrete-Time Systems
Based on the growth rate of the set of states reachable with unit-energy inputs, we show that a discrete-time controllable linear system is globally controllable to the origin with constrained inputs if and only if all its eigenvalues lie in the closed unit disk. These results imply that the constrained Infinite-Horizon Model Predictive Control algorithm is globally stabilizing for a sufficiently large number of control moves if and only if the controlled system is controllable and all its eigenvalues lie in the closed unit disk.
In the second part of the paper, we propose an implementable Model Predictive Control algorithm and show that with this scheme a discrete-time linear system with n poles on the unit disk (with any multiplicity) can be globally stabilized if the number of control moves is larger than n. For pure integrator systems, this condition is also necessary. Moreover, we show that global asymptotic stability is preserved for any asymptotically constant disturbance entering at the plant input
Characterizing the geometrical edges of nonlocal two-qubit gates
Nonlocal two-qubit gates are geometrically represented by tetrahedron known
as Weyl chamber within which perfect entanglers form a polyhedron. We identify
that all edges of the Weyl chamber and polyhedron are formed by single
parametric gates. Nonlocal attributes of these edges are characterized using
entangling power and local invariants. In particular, SWAP (power)alpha family
of gates constitutes one edge of the Weyl chamber with SWAP-1/2 being the only
perfect entangler. Finally, optimal constructions of controlled-NOT using
SWAP-1/2 gate and gates belong to three edges of the polyhedron are presented.Comment: 11 pages, 4 figures, Phys. Rev. A 79, 052339 (2009
Median computation in graphs using consensus strategies
Following the Majority Strategy in graphs, other consensus strategies, namely Plurality Strategy, Hill Climbing and Steepest Ascent Hill Climbing strategies on graphs are discussed as methods for the computation of median sets of profiles. A review ofalgorithms for median computation on median graphs is discussed and their time complexities are compared. Implementation of the consensus strategies on median computation in arbitrary graphs is discussed.majority strategy;consensus strategy;Hill climbing median computation
Probing the interplay between surface and bulk states in the topological Kondo insulator SmB through conductance fluctuation spectroscopy
We present results of resistance fluctuation spectroscopy on single crystals
of the predicted Kondo topological insulator material SmB. Our measurements
show that at low temperatures, transport in this system takes place only
through surface states. The measured noise in this temperature range arises due
to Universal Conductance Fluctuations whose statistics was found to be
consistent with theoretical predictions for that of two-dimensional systems in
the Symplectic symmetry class. At higher temperatures, we find signatures of
glassy dynamics and establish that the measured noise is caused by mobility
fluctuations in the bulk. We find that, unlike the topological insulators of
the dichalcogenide family, the noise in surface and bulk conduction channels in
SmB are completely uncorrelated. Our measurements establish that at
sufficiently low temperatures, the bulk has no discernible contribution to
electrical transport in SmB making it an ideal platform for probing the
physics of topological surface states.Comment: 9 pages, 11 figure
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