Sequential C–N and C–O Bond Formation in a Single Pot: Synthesis of 2<i>H</i>-Benzo[<i>b</i>][1,4]oxazines from 2,5-Dihydroxybenzaldehyde and Amino acid Precursors

Functionalized β-aryl alanine ester derivatives were found to undergo rapid C–N and C–O bond formation with quinol carbonyl compounds to afford 2<i>H</i>-benzo[<i>b</i>][1,4]oxazines in good to excellent yields. This unprecedented finding reported herein offers a straightforward, highly efficient, and rapid method for the synthesis of 2<i>H</i>-benzo[<i>b</i>][1,4]oxazines

Sequential C–N and C–O Bond Formation in a Single Pot: Synthesis of 2<i>H</i>-Benzo[<i>b</i>][1,4]oxazines from 2,5-Dihydroxybenzaldehyde and Amino acid Precursors

Functionalized β-aryl alanine ester derivatives were found to undergo rapid C–N and C–O bond formation with quinol carbonyl compounds to afford 2<i>H</i>-benzo[<i>b</i>][1,4]oxazines in good to excellent yields. This unprecedented finding reported herein offers a straightforward, highly efficient, and rapid method for the synthesis of 2<i>H</i>-benzo[<i>b</i>][1,4]oxazines