557 research outputs found
The perception of polish organic food consumers
This paper presents the problems concerning the organic food demand in Poland. It indicates the reasons for such small interest in this kind of food, the main motives of purchase, and the barriers of market development. It also shows the ways of developing the organic food market development
Alien Registration- Bakula, William (Portland, Cumberland County)
https://digitalmaine.com/alien_docs/25677/thumbnail.jp
Assessment of the effectiveness of in-service training regarding the care and maintenance of hearing aids to personnel of health care facilities
Amiodaron i tiroidna disfunkcija
Thyroid gland has a key role in maintaining the body homeostasis. Thyroxine is the
main hormone secreted from the thyroid gland, its effect being predominantly achieved after the intracellular
conversion of thyroxine to triiodothyronine, which exhibits a higher affinity for the receptor
complex, thus modifying gene expression of the target cells. Amiodarone is one of the most commonly
used antiarrhythmics in the treatment of a broad spectrum of arrhythmias, usually tachyarrhythmias.
Amiodarone contains a large proportion of iodine, which is, in addition to the intrinsic effect of the
medication, the basis of the impact on thyroid function. It is believed that 15%-20% of patients treated
with amiodarone develop some form of thyroid dysfunction. Amiodarone may cause amiodarone-induced
hypothyroidism (AIH) or amiodarone-induced thyrotoxicosis (AIT). AIT is usually developed
in the areas with too low uptake of iodine, while AIH is developed in the areas where there is a sufficient
iodine uptake. Type 1 AIT is more common among patients with an underlying thyroid pathology,
such as nodular goiter or Graves’ (Basedow’s) disease, while type 2 mostly develops in a previously
healthy thyroid. AIH is more common in patients with previously diagnosed Hashimoto’s thyroiditis.
Combined types of the diseases have also been described. Patients treated with amiodarone should
be monitored regularly, including laboratory testing and clinical examinations, to early detect any
deviations in the functioning of the thyroid gland. Supplementary levothyroxine therapy is the basis
of AIH treatment. In such cases, amiodarone therapy quite often need not be discontinued. Type 1
AIT is treated with thyrostatic agents, like any other type of thyrotoxicosis. If possible, the underlying
amiodarone therapy should be discontinued. In contrast to type 1 AIT, the basic pathophysiological
substrate of which is the increased synthesis and release of thyroid hormones, the basis of type 2 AIT
is destructive thyroiditis caused by amiodarone, desethylamiodarone as its main metabolite, and an
increased iodine uptake. Glucocorticoid therapy is the basis of treatment for this type of disease.Štitna žlijezda zauzima ključno mjesto u održavanju homeostaze cijeloga organizma. Temeljni hormon koji luči je tiroksin,
a učinak se dominantno ostvaruje nakon unutarnje konverzije tiroksina u aktivniji oblik, trijodotironin, koji pokazuje
veći afinitet za receptorski kompleks te time modificira gensku ekspresiju ciljnih stanica. Amiodaron je jedan od najčešće
upotrebljavanih antiaritmika i rabi se u liječenju širokog spektra aritmija, najčešće tahiaritmija. U svom sastavu sadrži velik
udio joda, što je, uz intrinzični učinak lijeka, temelj utjecaja na tireoidnu funkciju. Smatra se kako 15%-20% bolesnika liječenih
amiodaronom razvija neki oblik tireoidne disfunkcije. Amiodaron može biti uzrokom razvoja amiodaronom izazvane
hipotireoze (amiodarone-induced hypothyroidism, AIH) ili amiodaronom izazvane tireotoksikoze (amiodarone-induced thyrotoxicosis,
AIT). AIT se češće razvija u područjima sa smanjenim, dok se AIH razvija u područjima s dovoljnim unosom joda.
Razlikujemo dva tipa AIT; tip 1 je češći u bolesnika s podležećom tireoidnom patologijom, najčešće nodoznom strumom ili
latentnom Gravesovom (Basedowljevom) bolešću, dok se tip 2 najčešće razvija u prethodno zdravoj štitnjači. AIH je znatno
češća u bolesnika s otprije poznatim Hashimotovim tireoiditisom. Opisani su i miješani oblici bolesti. Bolesnike liječene
amiodaronom potrebno je redovito pratiti, laboratorijski i klinički, kako bi se pravodobno otkrila bilo kakva odstupanja u
tireoidnoj funkciji. Temelj liječenja AIH-a je nadomjesna terapija levotiroksinom. Često u tim slučajevima nije potrebno
izostavljati amiodaron iz terapije. AIT tipa 1 liječi se tireostaticima, kao i ostale tireotoksikoze. Ako je moguće, preporuča se
prekinuti podležeća amiodaronska terapija. Nasuprot AIT tipa 1, temeljni patofiziološki supstrat kojega je povećana sinteza i
otpuštanje tireoidnih hormona, u AIT tipu 2 osnova je destruktivni tireoiditis uzrokovan amiodaronom, dezetilamiodaronom
kao njegovim glavnim metabolitom i povećanim unosom joda. Osnova liječenja tog tipa bolesti je glukokortikoidna terapija
Overlap Syndrome at Rheumatology Department – Case Report
Systemic lupus erythematosus (SLE) is an autoimmune connective tissue disease, affecting mostly women of childbearing age. Dermatomyositis (DM) is a rare autoimmune inflammatory myopathy affecting both skin and muscles. Overlap syndrome is an autoimmune disease which shares features of at least two recognised connective tissue diseases. We present a case of an overlap syndrome refractory to treatment
Functional promoter polymorphism of the neuronal isoform of tryptophan hydroxylase (Tph2) in suicide
The association between suicide and G-703T polymorphism of the tryptophan hydroxylase 2 (TPH2), the rate-limiting enzyme in the biosynthesis of the neurotransmitter serotonin, was studied in a sample of 291 suicide victims and 280 healthy subjects of Croatian origin. No significant differences were found between the groups. Obtained results do not support involvement of the investigated polymorphism in the susceptibility to suicide completion
Accentuate the negative
A survey of mean inequalities with real weights is given.Comment: 16 pages 3 figure
Rare complications of Sjögren’s syndrome in a female patient
Sjögren’s syndrome (SjS) is a systemic autoimmune disease, most common in middle-aged women, characterized by chronic inflammation
of exocrine glands. It can present by itself or alongside other autoimmune diseases. Main symptoms are dry eyes and mouth, but the disease can affect joints, lungs, kidneys, peripheral nervous system (PNS), and rarely central nervous system (CNS). SS-A antibodies in SjS can pass the fetoplacental barrier and cause congenital heart block. Patients with SjS are at higher risk of developing lymphoma
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