Design, Synthesis, Characterization of Geminal Bisphosphonates and Bioactivity Evaluation

Cancer is a deadly disease evading all human efforts to understand its etiology, prevention, and cure. In cancer, chronic myelogenous leukemia is one type. It is also known as chronic myeloid leukemia. It is a malignant cancer of the myeloid line of cells in the bone marrow that results in the uncontrolled growth of white blood cells in the bone marrow, bloodstream, and body tissues. Colorectal cancer is another type of cancer that occurs in the colon or rectum. Sometimes it is called colon cancer. Management of these cancers is highly difficult. In persuasion of our goal to synthesize cancer active compounds, the author accomplished the synthesis of substituted amino methylene bisphosphonates (3a-j) and studied their antitumor activity. © 2020 Author(s)

Synthesis and Cytotoxic Activity of Various alkyl 2-{di[(diethoxy phosphoryl) methyl]amino}ester Derivatives

We have been synthesized simple, efficient various alkyl 2-{di[(diethoxy phosphoryl) methyl]amino}ester derivatives by reacting amino acid esters 1(a-j), paraformaldehyde and two molar equivalents of diethyl hydrogenphosphonate (2) in tetrahydrofuran at 55-65 °C for 10 hrs. All the compounds 3(a-j) were assessed for cytotoxicity against some important types of human chronic myeloid leukemia cells (K-562) and human colon carcinoma cells (Colo-205) along with noncancerous human embryonic kidney cells (HEK-293). © 2020 Author(s)

Toxic Effects of Glyphosate on Environment and Human Health

Globally, massive amounts of pesticides are manufactured and used both in agriculture and households to get rid of various pests, some of which reach soils and aquatic systems through various pathways. Glyphosate-based herbicides (GlyBH), including Roundup, are the most widely used pesticides worldwide. Glyphosate is a non-selective herbicide that is effective against all types of weeds and has been used for many years. Their uses have increased exponentially since their introduction into the market. Residue levels in food or water, as well as human exposures, are escalating including in the environmental segments. It can, therefore, be found as a contaminant in water, and procedures are required for its removal. This work investigates the toxic effects associated with the use of Glyphosate on environmental and human health. © 2020 Author(s).Dr. BGR is highly thankful to UGC for the award of Post Doctoral Fellowship, File No. F./PDFSS-2014-15-SCAND-7541

Nanoencapsulation of Pesticides: Sustainable Perspective in Agriculture

The concern towards the increasing challenges of sustainable agriculture made the researchers towards significant technological development and innovations in recent years. In particular, Nanotechnology offers potential solutions to improve agricultural production assuring sustainability. The incorporation of nanotechnology as a means of nano pesticides delivers the pesticides appropriately i.e., targeted delivery of pesticides by lowering the indiscriminate use of conventional pesticides. The assets of a nanoencapsulated pesticide formulation are controlled releasing properties with enhanced solubility, specificity, permeability and stability. They provide in-built switches to control the release and subsequent availability of pesticides to be used effectively over a given period of time and their design enables them to resist the severe environmental processes such as leaching, evaporation, photolytic hydrolytic and microbial degradation over conventional pesticides. This review provides fundamental information to critically assess the significant role of nanotechnology for the encapsulation of pesticides. © 2020 Author(s)

Synthesis of a New Class of Thiazolyl Morpholines / Thiomorpholines and Evaluation as Antimicrobials

The series of novel thiazole derivatives (4-5) have been synthesized. All the synthesized compounds were characterized by IR, 1H, 13C NMR, mass spectra. All the lead compounds were tested for antimicrobial activity. The compound 5f having chloro substituent on the aromatic ring displays greater antimicrobial activity particularly against P. aeruginosa and P. crysogenum. © 2020 Author(s).The authors G. Sravya and N. Bakkthavatchala Reddy are thankful to Ural Federal University, Yekaterinburg, Russia for giving postdoctoral fellowship

Synthesis, Structural Elucidation and Bioassay of Morpholine/Thiomorpholine and Piperidine Containing Oxazoles

The series of novel oxazole derivatives (3-4) have been synthesized. All the entitles compounds were characterized by IR, 1H, 13C NMR, mass spectra. All the lead compounds were tested for antimicrobial activity. The compound 4f having chloro substituent on the aromatic ring displays greater antimicrobial activity particularly against P. aeruginosa and P. crysogenum. © 2020 Author(s).The authors G. Sravya and N. Bakkthavatchala Reddy are thankful to Ural Federal University, Yekaterinburg, Russia for giving postdoctoral fellowship

Ultrasound-Assisted PSA Catalyzed One-Pot Green Synthesis of Pyrazolyl Pyrrole Derivatives

A fast, efficient and environmentally benign synthesis of pyrazolyl pyrrole derivatives has been developed by the one-pot multicomponent reaction of an aldehyde, nitroalkane, amine, and enolizable reactant with active C-H group, using Phosphosulfonic acid (PSA) as reusable solid acid catalyst under mild, solvent-free, ultra-sonication conditions. In comparison to the existing conventional methods, this green and efficient protocol provides remarkable advantages such as good to excellent yields, lower reaction time, less cost, easy work-up and solvent-free. © 2020 Author(s).The authors are thankful to Prof. C. Devendranath Reddy, Department of Chemistry, S.V. University, Tirupati for his helpful discussions and acknowledge DST-PURSE 2nd Phase Programme in S.V. University, Tirupati funded by DST-New Delhi, India for providing instrumentation facility and funding to Mr. Gundluru Mohan through SRF (File No: 17118-UGC-III (3)/ DST-PURSE 2nd Phase/2017, Dt: 23-08-2018)

Meglumine Sulphate: an Efficient Catalyst for the Synthesis of bis(indolyl)methanes

The reaction of indoles with carbonyl compounds in the presence of 5mol% Meglumine Sulphate (MS) in acetonitrile was executed to synthesize bis(indolyl)methane derivatives using conventional and ultrasonication methods. The reaction proceeded in shorter reaction time in ultrasonication methodology leading to high yield of the products. © 2020 Author(s)