Synthesis of 5-methyl-1,2,4-triazolo[1,5- a] pyrimidin-7(4 H)-one - A semi-product of the synthesis of antiviral drug triazide® in the conditions of microwave excitation

5-Methyl-1,2,4-triazolo[1,5-a]pyrimidine-7(4H)-one was synthesized (the intermediate product for the syn-thesis of the antiviral drug Triazide®) under microwave radiation. Conversion of the starting reagents to the target product reached 95% due to experimentally selected conditions. © 2019 Author(s)

Synthesis of 5-Methyl-1,2,4-Triazolo[1,5-а]Pyrimidin-7(4H)-One-a Semi-Product of the Synthesis of Antiviral Drug Triazide® in the Conditions of Microwave Excitation

This work was supported by the Russian Science Foundation (Ref. № 18-13-00365)

New 2,5-bis(2-ethylhexyl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione-2,2’-bipyridine-based co-polymer, synthesis, photophysical properties and response to metal cations

A new co-polymer based on fragments of 2-(2-pyridyl)monoazatriphenylene and 2,5-bis (2-ethylhexyl)-3,6-di(thiophen-2-yl)pyrrolo[3,4-c]pyrrole-1,4(2H,5H)-dione was prepared by using the Sonogashira reaction. The photophysical properties of the polymer were studied. The presence of a strong bathochromic shift of the absorption and emission maxima in comparison with the previously described monomer units is shown. The polymer exhibits an intense “turn-off” response toward Cu2+ cations

(Mechano)synthesis of azomethine- and terpyridine-linked diketopyrrolopyrrole-based polymers

Three efficient synthetic approaches towards new azomethine- and terpyridine-containing 2,5-dihydropyrrolo[3,4-c]pyrrole-1,4-dione (diketopyrrolopyrrole, DPP) based polymers, such as P1 and P2, are reported. The first approach involves the Pd-catalyzed synthesis via two- or three-component Suzuki or Stille cross-coupling reaction in solution. The second approach involves Pd-catalyzed Suzuki cross-coupling reaction under ball-milling conditions. And, finally, the third approach involves Pd-free condensation reaction under ball-milling conditions. The newly obtained polymers exhibited absorbance around 700 nm and emission around 900 nm, and, thus, these polymers are considered to be NIR-fluorophores

QUANTITATIVE DETERMINATION OF VITAMINS A, D3 AND E IN PREMIXES «MAUERVIT» AND «GRANDVITAM» BY ULTRA HPLC

A convenient method for analyzing the content of vitamins A, D3 and E in premixes has been developed (the tests were carried out using the example of the premixes «Mauervit» and «randvitam») using ultra HPLC. The necessary changes of the procedure have been made in comparison with the ones presented previously in GOST R 50928-96 due to the presence in the premix components hampering analysis (in particular, Tween 80). The developed procedure has been tested in terms of specificity, accuracy and precision. In addition, the possibility of using a simpler procedure for the analysis of vitamins extract, used as raw material for premix production, has been demonstrated

SIMULTANEOUS DETERMINATION OF AMINOTRIAZOLE AND TRIAZOLOPYRIMIDINONE - SUBSTRATE AND INTERMEDIATE IN THE SYNTHESIS OF «TRIAZIDE» BY HPLC

Method of simultaneous determination of aminotriazole and triazolopyrimidinone using HPLC with UV-detection was developed. For best chromatographic performance Zorbax NH2 amino phase column (Agilent Technologies, USA) was selected. The applicability of the developed method for providing technological control of the 1st stage of «Triazide» production was approved according to the results of validation procedure

METHOD OF DETERMINATION OF 5-METHYL-6-NITRO-7-OXO-1,2,4-TRIAZOLO[1,5-<i>a</i>]PIRIMIDINIDE <i>l-</i>ARGININY - THE ACTIVE COMPONENT OF DRUG «TRIAZID» BY HPLC METHOD

A procedure for quantitative determination of 5-methyl-6-nitro-7-oxo-1,2,4-triazolo[1,5-a]pirimidinide l -argininy was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted octadecylsilyl phase 5-100-c18 (EKA, Sweden). The possibility of applying the developed procedure for the technological control of the third stage of the drug «Triazid» preparation was proved by the validation

METHOD OF SIMANTENOUS DETERMINATION OF AMINOTRIAZOLE, TRIAZOLOPYRIMIDINONE AND NITROTRIAZOLOPIRIMIDINONE - SUBSTRATE AND SEMI-PRODUCTS OF SYNTHESIS OF DRUG «TRIAZID» BY HPLC METHOD

A procedure for the simantenous determination of aminotriazole, triazolopyrimidinone and nirotriazolopyrimidinone was developed using the HPLC method with UV detection. To achieve the best chromatographic characteristics, it is proposed to use a column with a grafted aminophase Zorbax NH2 (Agilent Technologies, USA). The possibility of applying the developed methodology for the technological control of the second stage of the drug «Triazid» preparation is established following the results of the validation

Deep multilevel wet etching of fused silica glass microstructures in BOE solution

Abstract Fused silica glass is a material of choice for micromechanical, microfluidic, and optical devices due to its chemical resistance, optical, electrical, and mechanical performance. Wet etching is the key method for fabricating of such microdevices. Protective mask integrity is a big challenge due extremely aggressive properties of etching solution. Here, we propose multilevel microstructures fabrication route based on fused silica deep etching through a stepped mask. First, we provide an analysis of a fused silica dissolution mechanism in buffered oxide etching (BOE) solution and calculate the main fluoride fractions like $${HF}_{2}^{-}$$ HF 2 - , $${F}^{-}$$ F - , $${(HF)}_{2}$$ ( H F ) 2 as a function of pH and NH4F:HF ratio. Then, we experimentally investigate the influence of BOE composition (1:1–14:1) on the mask resistance, etch rate and profile isotropy during deep etching through a metal/photoresist mask. Finally, we demonstrate a high-quality multilevel over-200 μm etching process with the rate up to 3 μm/min, which could be of a great interest for advanced microdevices with flexure suspensions, inertial masses, microchannels, and through-wafer holes

Low-Damage Reactive Ion Etching of Nanoplasmonic Waveguides with Ultrathin Noble Metal Films

Nanoplasmonic waveguides utilizing surface plasmon polaritons (SPPs) propagation have been investigated for more than 15 years and are now well understood. Many researchers make their efforts to find the best ways of using light and overcoming the speed limit of integrated circuits by means of SPPs. Here, we introduce the simulation results and fabrication technology of dielectric-metal-dielectric long-range nanoplasmonic waveguides, which consists of a multilayer stack based on ultrathin noble metals in between alumina thin films. Various waveguide topologies are simulated to optimize all the geometric and multilayer stack parameters. We demonstrate the calculated propagation length of Lprop = 0.27 mm at the 785 nm wavelength for the Al2O3/Ag/Al2O3 waveguides. In addition, we numerically show the possibility to eliminate signal cross-talks (less than 0.01%) between two crossed waveguides. One of the key technology issues of such waveguides&rsquo; nanofabrication is a dry, low-damage-etching of a multilayer stack with extremely sensitive ultrathin metals. In this paper, we propose the fabrication process flow, which provides both dry etching of Al2O3/Au(Ag)/Al2O3 waveguides nanostructures with high aspect ratios and non-damage ultrathin metal films patterning. We believe that the proposed design and fabrication process flow provides new opportunities in next-generation photonic interconnects, plasmonic nanocircuitry, quantum optics and biosensors