Determining intrafractional prostate motion using four dimensional ultrasound system

BACKGROUND: In prostate radiotherapy, it is essential that the prostate position is within the planned volume during the treatment delivery. The aim of this study is to investigate whether intrafractional motion of the prostate is of clinical consequence, using a novel 4D autoscan ultrasound probe. METHODS: Ten prostate patients were ultrasound (US) scanned at the time of CT imaging and once a week during their course of radiotherapy treatment in an ethics-approved study, using the transperineal Clarity autoscan system (Clarity®, Elekta Inc., Stockholm, Sweden). At each US scanning session (fraction) the prostate was monitored for 2 to 2.5 min, a typical beam-on time to deliver a RapidArc® radiotherapy fraction. The patients were instructed to remain motionless in supine position throughout the US scans. They were also requested to comply with a bladder-filling protocol. In total, 51 monitoring curves were acquired. Data of the prostate motion in three orthogonal directions were analyzed. Finally, the BMI value was calculated to investigate correlation between BMI and the extent of prostate displacement. RESULTS: The patients were cooperative, despite extra time for applying the TPUS scan. The mean (±1SD) of the maximal intrafractional displacements were [mm]; I(+)/S: (0.2 ± 0.9); L(+)/R: (−0.2 ± 0.8); and A(+)/P: (−0.2 ± 1.1), respectively. The largest displacement was 2.8 mm in the posterior direction. The percentage of fractions with displacements larger than 2.0 mm was 4 %, 2 %, and 10 % in the IS, LR, and AP directions, respectively. The mean of the maximal intrafractional Euclidean distance (3D vector) was 0.9 ± 0.6 mm. For 12 % of the fractions the maximal 3D vector displacements were larger than 2.0 mm. At only two fractions (4 %) displacements larger than 3.0 mm were observed. There was no correlation between BMI and the extent of the prostate displacement. CONCLUSIONS: The prostate intrafractional displacement is of no clinically consequence for treatment times in the order of 2 – 2.5 min, which is typical for a RapidArc radiotherapy fraction. However, prostate motion should be considered for longer treatment times eg if applying conventional or IMRT radiotherapy

Evaluation of uterine ultrasound imaging in cervical radiotherapy; a comparison of autoscan and conventional probe

OBJECTIVE: In cervical radiotherapy, it is essential that the uterine position is correctly determined prior to treatment delivery. The aim of this study was to evaluate an autoscan ultrasound (A-US) probe, a motorized transducer creating three-dimensional (3D) images by sweeping, by comparing it with a conventional ultrasound (C-US) probe, where manual scanning is required to acquire 3D images. METHODS: Nine healthy volunteers were scanned by seven operators, using the Clarity(®) system (Elekta, Stockholm, Sweden). In total, 72 scans, 36 scans from the C-US and 36 scans from the A-US probes, were acquired. Two observers delineated the uterine structure, using the software-assisted segmentation in the Clarity workstation. The data of uterine volume, uterine centre of mass (COM) and maximum uterine lengths, in three orthogonal directions, were analyzed. RESULTS: In 53% of the C-US scans, the whole uterus was captured, compared with 89% using the A-US. F-test on 36 scans demonstrated statistically significant differences in interobserver COM standard deviation (SD) when comparing the C-US with the A-US probe for the inferior–superior (p < 0.006), left–right (p < 0.012) and anteroposterior directions (p < 0.001). The median of the interobserver COM distance (Euclidean distance for 36 scans) was reduced from 8.5 (C-US) to 6.0 mm (A-US). An F-test on the 36 scans showed strong significant differences (p < 0.001) in the SD of the Euclidean interobserver distance when comparing the C-US with the A-US scans. The average Dice coefficient when comparing the two observers was 0.67 (C-US) and 0.75 (A-US). The predictive interval demonstrated better interobserver delineation concordance using the A-US probe. CONCLUSION: The A-US probe imaging might be a better choice of image-guided radiotherapy system for correcting for daily uterine positional changes in cervical radiotherapy. ADVANCES IN KNOWLEDGE: Using a novel A-US probe might reduce the uncertainty in interoperator variability during ultrasound scanning