Synthesis and in vitro antiproliferative activity of novel (4-chloro- and 4-acyloxy-2-butynyl)thioquinolines

The series of new acetylenic thioquinolines containing propargyl, 4-chloro-2-butynyl, and 4-acyloxy-2-butynyl groups have been prepared and tested for antiproliferative activity in vitro against human [SW707 (colorectal adenocarcinoma), CCRF/CEM (leukemia), T47D (breast cancer)] and murine [P388 (leukemia), B16 (melanoma)] cancer lines. Most of the obtained compounds exhibited antiproliferative activity, especially compounds 8, 12, and 21 showed the ID50 values ranging from 0.4 to 3.8 μg/ml comparable to that of cisplatin used as reference compounds

Measurements of π±\pi^\pm, K±K^\pm, pp and pˉ\bar{p} spectra in 40^{40}Ar+45^{45}Sc collisions at 13AA to 150AA GeV/cc

The NA61/SHINE experiment at the CERN Super Proton Synchrotron studies the onset of deconfinement in strongly interacting matter through a beam energy scan of particle production in collisions of nuclei of varied sizes. This paper presents results on inclusive double-differential spectra, transverse momentum and rapidity distributions and mean multiplicities of $\pi^\pm$, $K^\pm$, $p$ and $\bar{p}$ produced in $^{40}$Ar+$^{45}$Sc collisions at beam momenta of 13$A$, 19$A$, 30$A$, 40$A$, 75$A$ and 150$A$ GeV/$c$. The analysis uses the 10% most central collisions, where the observed forward energy defines centrality. The energy dependence of the $K^\pm$/$\pi^\pm$ ratios as well as of inverse slope parameters of the $K^\pm$ transverse mass distributions are placed in between those found in inelastic $p$+$p$ and central Pb+Pb collisions. The results obtained here establish a system-size dependence of hadron production properties that so far cannot be explained either within statistical (SMES, HRG) or dynamical (EPOS, UrQMD, PHSD, SMASH) models

Search for the critical point of strongly-interacting matter in 40^{40}Ar + 45^{45}Sc collisions at 150A Ge V /c using scaled factorial moments of protons

The critical point of dense, strongly interacting matter is searched for at the CERN SPS in $^{40}$Ar + $^{45}$Sc collisions at 150A Ge V /c. The dependence of second-order scaled factorial moments of proton multiplicity distribution on the number of subdivisions of transverse momentum space is measured. The intermittency analysis is performed using both transverse momentum and cumulative transverse momentum. For the first time, statistically independent data sets are used for each subdivision number. The obtained results do not indicate any statistically significant intermittency pattern. An upper limit on the fraction of correlated proton pairs and the power of the correlation function is obtained based on a comparison with the Power-law Model developed for this purpose

Measurements of π+\pi^+, π−\pi^-, pp, pˉ\bar{p}, K+K^+ and K−K^- production in 120 GeV/cc p + C interactions

This paper presents multiplicity measurements of charged hadrons produced in 120 GeV/$c$ proton-carbon interactions. The measurements were made using data collected at the NA61/SHINE experiment during two different data-taking periods, with increased phase space coverage in the second configuration due to the addition of new subdetectors. Particle identification via $dE/dx$ was employed to obtain double-differential production multiplicities of $\pi^+$, $\pi^-$, $p$, $\bar{p}$, $K^+$ and $K^-$. These measurements are presented as a function of laboratory momentum in intervals of laboratory polar angle covering the range from 0 to 450 mrad. They provide crucial inputs for current and future long-baseline neutrino experiments, where they are used to estimate the initial neutrino flux

Geotechnical tests for estimation of geological conditions of the escarpment zone of “Skarpa Warszawska” in the vicinity of Tamka Street

Badania prowadzono w strefie przyskarpowej plejstoceńskiej wysoczyzny morenowej, na granicy z doliną Wisły. Powierzchnia terenu jest tu w dużym stopniu przeobrażona antropogenicznie. Wielokrotna przebudowa obejmująca budynki mieszkalne oraz trasy komunikacyjne zatarła pierwotne cechy rzeźby obszaru, utrudniając konstrukcję modelu jego morfogenezy. W ramach prac terenowych wykonano wiercenia geologiczne oraz sondowania geotechniczne CPTU i DMT. Przeprowadzono też laboratoryjne badania właściwości próbek gruntów (próbki klasy 1, 3 i 4) pobranych w czasie badań terenowych. Wyniki prac pozwoliły na wydzielenie w obrębie analizowanej strefy serii utworów koluwialno-deluwialnych, aluwiów okresowych cieków, a także serię utworów podłoża czwartorzędu zbudowanych z osadów ilastych pliocenu. Przebieg granic poszczególnych wydzieleń litogenetycznych, włączając w to zróżnicowaną pod względem gruntoznawczym warstwę antropogeniczną, uszczegóławiano w oparciu o wyniki sondowań geotechnicznych oraz oznaczone właściwości fizyczno-mechaniczne budujących je gruntów.Investigations were carried out in the escarpment zone of the Pleistocene moraine upland, on the border zone of Vistula River Valley. Surface of this area is transformed due to the human activity. Features of original morphology have been hidden by the repeated engineering works, consist of construction of houses and traffic routes and have made that the morphogenesis of this area is difficult to be identified. Field works consisted of geological drilling and geotechnical soundings CPTU (cone penetrating testing) and DMT (Marchetti dilatometer) as well as collecting soils samples (quality class 1, 3 and 4). Soil properties were determined also during the laboratory works. Results of investigations enabled the distinguishing in geological profile sections as: colluvial-deluvial section, alluvia of periodical streams, as well as direct Quaternary substratum, lacustrine Pliocene clays (so called “varicolored clay”). The courses and boundaries of each, particular layer, including the complex anthropogenic soils were specified on the base of the obtained measures of geotechnical parameters and physical-mechanical properties

Pyromorphite formation from montmorillonite adsorbed lead

The reaction of Pb-adsorbed montmorillonite with aqueous solutions of PO4 and Cl ions results in the decrease in phosphate concentration associated with the formation of a new phase – pyromorphite Pb5(PO4)3Cl. Pyromorphite crystals range in size from hundreds of nm to several tens of μm, depending on the PO4, K, and Ca concentrations in the reacting system. A strong ion-exchange effect of K+ and Ca2+ cations on desorption of Pb2+ from Pb-adsorbed montmorillonite was observed. Also, a high concentration of cations leads to a rapid desorption of Pb and the formation of fine pyromorphite crystals. In contrast, low PO4, K and Ca concentrations result in the formation of relatively large euhedral crystals. Final Pb concentrations are much lower in experimental sets than in control experiments with no phosphate present