14 research outputs found
Safety and tolerability evaluation after repeated intravitreal injections of a humanized anti-human VEGF-A monoclonal antibody (PRO-169) versus Ranibizumab in albino New Zealand rabbits.
To evaluate the long-term retinal toxicity after repeated intravitreal injection of a humanized anti-human VEGF mAb vs ranibizumab in New Zealand rabbit eyes
Viability of a dry eye preclinical model in New Zealand White Rabbits during and following topical instillation of ophthalmic atropine sulfate 1.0%
This study’s objective was to confirm the viability of a dry eye (DE) rabbit model during and after administration of ophthalmic atropine sulfate (OAS) 1.0% in New Zealand white (NZW) rabbits. OAS 1.0% was applied three times per day (TID) to 30 eyes of 15 healthy NZW rabbits. Sacrifice, enucleation and lacrimal gland removal took place on days 15, 21, and 30 (OAS group). A second group (n=5) was used as control