6,800 research outputs found
Experimental assessment of predation risk for juvenile green sturgeon, Acipenser medirostris, by two predatory fishes
Roles for Ca2+ mobilization and its regulation in mast cell functions: recent progress
Ca(2+)mobilization in response to cross-linking of IgE bound to its high affinity receptor, FcεRI, on mast cells is central to immune allergic responses. Stimulated tyrosine phosphorylation caused by this cross-linking activates store-operated Ca(2+)entry that results in sustained Ca(2+)oscillations dependent on Rho family GTPases and phosphoinositide synthesis. Coupling of the endoplasmic reticulum (ER) Ca(2+)sensor, stromal interaction molecule 1 (STIM1), to the Ca(2+)-selective channel, Orai1, is regulated by these elements and depends on membrane organization, both at the plasma membrane and at the ER. Mitochondria also contribute to the regulation of Ca(2+)mobilization, and we describe recent evidence that the ER membrane protein vesicle-associated membrane protein-associated protein (VAP) plays a significant role in the coupling between ER and mitochondria in this process. In addition to granule exocytosis, Ca(2+)mobilization in these cells also contributes to stimulated outward trafficking of recycling endosomes and to antigen-stimulated chemotaxis, and it is pathologically regulated by protozoan parasitic invasion
Perfect fluids from high power sigma-models
Certain solutions of a sextic sigma-model Lagrangian reminiscent of Skyrme
model correspond to perfect fluids with stiff matter equation of state. We
analyse from a differential geometric perspective this correspondence extended
to general barotropic fluids.Comment: 17 pages. Version published in IJGMMP 8 (2011). Added Example 3.4 and
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Measles vaccination and antibody response in autism spectrum disorder
OBJECTIVE: To test the hypothesis that measles vaccination was involved in the pathogenesis of autism spectrum disorders (ASD) as evidenced by signs of a persistent measles infection or abnormally persistent immune response shown by circulating measles virus or raised antibody titres in children with ASD who had been vaccinated against measles, mumps and rubella (MMR) compared with controls. DESIGN: Case-control study, community based. METHODS: A community sample of vaccinated children aged 10-12 years in the UK with ASD (n = 98) and two control groups of similar age, one with special educational needs but no ASD (n = 52) and one typically developing group (n = 90), were tested for measles virus and antibody response to measles in the serum. RESULTS: No difference was found between cases and controls for measles antibody response. There was no dose-response relationship between autism symptoms and antibody concentrations. Measles virus nucleic acid was amplified by reverse transcriptase-PCR in peripheral blood mononuclear cells from one patient with autism and two typically developing children. There was no evidence of a differential response to measles virus or the measles component of the MMR in children with ASD, with or without regression, and controls who had either one or two doses of MMR. Only one child from the control group had clinical symptoms of possible enterocolitis. CONCLUSION: No association between measles vaccination and ASD was shown
Scaling Behaviour and Complexity of the Portevin-Le Chatelier Effect
The plastic deformation of dilute alloys is often accompanied by plastic
instabilities due to dynamic strain aging and dislocation interaction. The
repeated breakaway of dislocations from and their recapture by solute atoms
leads to stress serrations and localized strain in the strain controlled
tensile tests, known as the Portevin-Le Chatelier (PLC) effect. In this present
work, we analyse the stress time series data of the observed PLC effect in the
constant strain rate tensile tests on Al-2.5%Mg alloy for a wide range of
strain rates at room temperature. The scaling behaviour of the PLC effect was
studied using two complementary scaling analysis methods: the finite variance
scaling method and the diffusion entropy analysis. From these analyses we could
establish that in the entire span of strain rates, PLC effect showed Levy walk
property. Moreover, the multiscale entropy analysis is carried out on the
stress time series data observed during the PLC effect to quantify the
complexity of the distinct spatiotemporal dynamical regimes. It is shown that
for the static type C band, the entropy is very low for all the scales compared
to the hopping type B and the propagating type A bands. The results are
interpreted considering the time and length scales relevant to the effect.Comment: 35 pages, 6 figure
A characterization of Dirac morphisms
Relating the Dirac operators on the total space and on the base manifold of a
horizontally conformal submersion, we characterize Dirac morphisms, i.e. maps
which pull back (local) harmonic spinor fields onto (local) harmonic spinor
fields.Comment: 18 pages; restricted to the even-dimensional cas
Proposal for the determination of nuclear masses by high-precision spectroscopy of Rydberg states
The theoretical treatment of Rydberg states in one-electron ions is
facilitated by the virtual absence of the nuclear-size correction, and
fundamental constants like the Rydberg constant may be in the reach of planned
high-precision spectroscopic experiments. The dominant nuclear effect that
shifts transition energies among Rydberg states therefore is due to the nuclear
mass. As a consequence, spectroscopic measurements of Rydberg transitions can
be used in order to precisely deduce nuclear masses. A possible application of
this approach to the hydrogen and deuterium, and hydrogen-like lithium and
carbon is explored in detail. In order to complete the analysis, numerical and
analytic calculations of the quantum electrodynamic (QED) self-energy remainder
function for states with principal quantum number n=5,...,8 and with angular
momentum L=n-1 and L=n-2 are described (j = L +/- 1/2).Comment: 21 pages; LaTe
Microwave Assisted Synthesis of Py-Im Polyamides
Microwave synthesis was utilized to rapidly build Py-Im polyamides in high yields and purity using Boc-protection chemistry on Kaiser oxime resin. A representative polyamide targeting the 5′-WGWWCW-3′ (W = A or T) subset of the consensus Androgen and Glucocorticoid Response Elements was synthesized in 56% yield after 20 linear steps and HPLC purification. It was confirmed by Mosher amide derivatization of the polyamide that a chiral α-amino acid does not racemize after several additional coupling steps
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