Geographic patterns of genome admixture in latin American mestizos

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.La lista completa de autores que integran el documento puede consultarse en el archivo.Instituto Multidisciplinario de Biología Celula

Geographic patterns of genome admixture in latin American mestizos

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.La lista completa de autores que integran el documento puede consultarse en el archivo.Instituto Multidisciplinario de Biología Celula

Editorial

Editoria

Editorial

Editoria

Farmacogenética en poblaciones sudamericanas

Las diferencias alélicas en los genes del Citocromo P450 2D6 (GSTM1), de la N-aceliltransferasa (NAT2) y del Glutatión transferasa m1 (GSTM1) han mostrado estar asociadas con el riesgo genético de desarrollar enfermedades ambientales y ocupacionales. Estas enzimas exhiben variabilidad en la actividad metabólica, ocasionada por variantes alelicas producidas por mutaciones. Este es un estudio preliminar de las frecuencias alélicas de los genes CYP2D6, NAT2 y GSTM1 en Nativos Americanos. Se han analizado 128 cromosomas pertenecientes a 6 poblaciones diferentes: 4 de Argentina (Wichi, Tehuelche, Mapuche y Jujuy) y 2 de Paraguay (Lengua, Ayoreo). Se analizaron 9 mutaciones diagnósticas del gen CYP2D6: C188T, G212A, Ins T226, Del T1795, G1846T/A, G1934A, C2938T, DelA2637 y G1749C; 3 mutaciones de gen NAT2: 481T, 590A y 857C; y la pérdida del gen GSTM1. Se encontró un aumento significativo (P<0.001) en los alelos 10, 12 y 14 del gen CYP2D6 entre nuestros resultados y los descriptos para poblaciones Europeas. Se encontraron un aumento de la frecuencia del 857C y una disminución del alelo 590A del gen NAT2 que fueron significativos (P<0.001). También fue significativo el descenso de la frecuencia del genotipo homocigota nulo del gen GSTM1(P=0.047). La frecuencia genotipica de los homocigotas de bajo poder metabolizante en poblaciones americanas no mostró menor capacidad metabolizante promedio.Asociación de Antropología Biológica de la República Argentin

Nota editorial

Presentación de los contenidos de la revista.Asociación de Antropología Biológica de la República Argentina (AABRA

Nota editorial

Presentación de los contenidos de la revista.Asociación de Antropología Biológica de la República Argentina (AABRA

Néstor O. Bianchi (1931-2023) : Obituario

Semblanza biográfica de Néstor O. Bianchi (1931-2023).Asociación de Antropología Biológica Argentin

Copyright and good practices in scientific publications

Las publicaciones científicas constituyen un importante indicador de la trayectoria laboral de un investigador, resultante de intereses, restricciones y de diversas negociaciones. Un lugar en que se manifiestan muchos de estos elementos es la configuración de las autorías del trabajo. Esto suele ser motivo de tensiones cuando, por ejemplo, en la lista de autores de un trabajo se excluye a alguien que generó determinado tipo de información o contenido; así como cuando se incorporan autores por devolución de gentilezas que nada aportaron a dicho contenido. Como investigadoras y editoras de la Revista Argentina de Antropología Biológica, basándonos en nuestra experiencia y en comentarios recibidos de algunos colegas en el ejercicio de actividades de investigación, entendemos que es necesario aportar elementos de reflexión sobre este tema. Los objetivos de este trabajo son los de a) visibilizar la problemática sobre el reconocimiento de autorías en las publicaciones y b) aportar algunas directrices para garantizar el respeto a los derechos de autor.Scientific publications are considered an important indicator of a researcher’s career, resulting from interests, restrictions, and various negotiations. The configuration of authorship can be a source of tension, for example, when someone who generated a certain type of information or content is excluded from the list of authors of a work, or also, when someone is incorporated as author in a manner of return of courtesies, although they contributed nothing to the said content. As researchers and editors of the Revista Argentina de Antropología Biológica, based on our experience and comments received from colleagues during research activities, we understand that it is necessary to contribute elements of reflection on this topic. The objectives of this work are to a) make visible the problems regarding the recognition of authorship in publications, and b) provide some guidelines to guarantee respect for copyright.Asociación de Antropología Biológica de la República Argentin

Geographic patterns of genome admixture in latin American mestizos

The large and diverse population of Latin America is potentially a powerful resource for elucidating the genetic basis of complex traits through admixture mapping. However, no genome-wide characterization of admixture across Latin America has yet been attempted. Here, we report an analysis of admixture in thirteen Mestizo populations (i.e. in regions of mainly European and Native settlement) from seven countries in Latin America based on data for 678 autosomal and 29 X-chromosome microsatellites. We found extensive variation in Native American and European ancestry (and generally low levels of African ancestry) among populations and individuals, and evidence that admixture across Latin America has often involved predominantly European men and both Native and African women. An admixture analysis allowing for Native American population subdivision revealed a differentiation of the Native American ancestry amongst Mestizos. This observation is consistent with the genetic structure of pre-Columbian populations and with admixture having involved Natives from the area where the Mestizo examined are located. Our findings agree with available information on the demographic history of Latin America and have a number of implications for the design of association studies in population from the region.La lista completa de autores que integran el documento puede consultarse en el archivo.Instituto Multidisciplinario de Biología Celula