Secondary renal neoplasms

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/42395/1/261-23-3-266_23n3p266.pd

ROC study of the effect of stereoscopic imaging on assessment of breast lesions

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135047/1/mp0172.pd

Logistics impacts of student online shopping – Evaluating delivery consolidation to halls of residence

Growth in online shopping has led to increased numbers of small delivery vehicles in urban areas leading to a range of negative externalities. Young people are significant generators of home deliveries and, when clustered in university halls of residence, can generate considerable freight traffic to one location. This paper explores the potential to consolidate these deliveries using an urban consolidation centre. Based on the case of Southampton, UK, data were compiled from three linked sources: a delivery audit of four halls of residence at the University of Southampton housing 5050 residents; annual package receipt records from Southampton Solent University halls (2294 residents); and an online shopping survey distributed to Southampton University students (486 responses). The results suggest that in cities with multiple higher education institutions (HEIs), where in excess of 8000 students live in halls, over 13,000 courier trips could be generated annually, delivering over 4000 m3 of packages. These could be consolidated onto fewer than 300 vehicles for an annual service cost of approximately £18 per student, reducing congestion, parking infringements and improving air quality. Analysis indicated student acceptance of a consolidated parcel service but operational challenges would include enforcement, performance risk, finance and delivery speed

Imaging Radiation-Induced Normal Tissue Injury

Technological developments in radiation therapy and other cancer therapies have led to a progressive increase in five-year survival rates over the last few decades. Although acute effects have been largely minimized by both technical advances and medical interventions, late effects remain a concern. Indeed, the need to identify those individuals who will develop radiation-induced late effects, and to develop interventions to prevent or ameliorate these late effects is a critical area of radiobiology research. In the last two decades, preclinical studies have clearly established that late radiation injury can be prevented/ameliorated by pharmacological therapies aimed at modulating the cascade of events leading to the clinical expression of radiation-induced late effects. These insights have been accompanied by significant technological advances in imaging that are moving radiation oncology and normal tissue radiobiology from disciplines driven by anatomy and macrostructure to ones in which important quantitative functional, microstructural, and metabolic data can be noninvasively and serially determined. In the current article, we review use of positron emission tomography (PET), single photon emission tomography (SPECT), magnetic resonance (MR) imaging and MR spectroscopy to generate pathophysiological and functional data in the central nervous system, lung, and heart that offer the promise of, (1) identifying individuals who are at risk of developing radiation-induced late effects, and (2) monitoring the efficacy of interventions to prevent/ameliorate them

An observer study comparing spot imaging regions selected by radiologists and a computer for an automated stereo spot mammography technique

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/134832/1/mp7492.pd

Effects of magnification and zooming on depth perception in digital stereomammography: an observer performance study

We are evaluating the application of stereoscopic imaging to digital mammography. In the current study, we investigated the effects of magnification and zooming on depth perception. A modular phantom was designed which contained six layers of 1-mm-thick Lexan plates, each spaced 1 mm apart. Eight to nine small, thin nylon fibrils were pasted on each plate in horizontal or vertical orientations such that they formed 25 crossing fibril pairs in a projected image. The depth separation between each fibril pair ranged from 2 to 10 mm. A change in the order of the Lexan plates changed the depth separation of the two fibrils in a pair. Stereoscopic image pairs of the phantom were acquired with a GE full-field digital mammography system. Three different phantom configurations were imaged. All images were obtained using a Rh target/Rh filter spectrum at 30 kVp tube potential and a ±3° stereo shift angle. Images were acquired in both contact and 1.8X magnification geometry and an exposure range of 4 to 63 mAs was employed. The images were displayed on a Barco monitor driven by a Metheus stereo graphics board and viewed with LCD stereo glasses. Five observers participated in the study. Each observer visually judged whether the vertical fibril was in front of or behind the horizontal fibril in each fibril pair. It was found that the accuracy of depth discrimination increased with increasing fibril depth separation and x-ray exposure. The accuracy was not improved by electronic display zooming of the contact stereo images by 2X. Under conditions of high noise (low mAs) and small depth separation between the fibrils, the observers' depth discrimination ability was significantly better in stereo images acquired with geometric magnification than in images acquired with a contact technique and displayed with or without zooming. Under our experimental conditions, a 2 mm depth discrimination was achieved with over 60% accuracy on contact images with and without zooming, and with over 90% accuracy on magnification images. This study indicates that stereoscopic imaging, especially with magnification, may be useful for visualizing the spatial distribution of microcalcifications in a cluster and for differentiating overlapping tissues from masses on mammograms.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/48976/2/pmb3_22_007.pd

Investigation of altering single-nucleotide polymorphism density on the power to detect trait loci and frequency of false positive in nonparametric linkage analyses of qualitative traits

Genome-wide linkage analysis using microsatellite markers has been successful in the identification of numerous Mendelian and complex disease loci. The recent availability of high-density single-nucleotide polymorphism (SNP) maps provides a potentially more powerful option. Using the simulated and Collaborative Study on the Genetics of Alcoholism (COGA) datasets from the Genetics Analysis Workshop 14 (GAW14), we examined how altering the density of SNP marker sets impacted the overall information content, the power to detect trait loci, and the number of false positive results. For the simulated data we used SNP maps with density of 0.3 cM, 1 cM, 2 cM, and 3 cM. For the COGA data we combined the marker sets from Illumina and Affymetrix to create a map with average density of 0.25 cM and then, using a sub-sample of these markers, created maps with density of 0.3 cM, 0.6 cM, 1 cM, 2 cM, and 3 cM. For each marker set, multipoint linkage analysis using MERLIN was performed for both dominant and recessive traits derived from marker loci. Our results showed that information content increased with increased map density. For the homogeneous, completely penetrant traits we created, there was only a modest difference in ability to detect trait loci. Additionally, as map density increased there was only a slight increase in the number of false positive results when there was linkage disequilibrium (LD) between markers. The presence of LD between markers may have led to an increased number of false positive regions but no clear relationship between regions of high LD and locations of false positive linkage signals was observed

MYC activation cooperates with Vhl and Ink4a/Arf loss to induce clear cell renal cell carcinoma

Renal carcinoma is a common and aggressive malignancy whose histopathogenesis is incompletely understood and that is largely resistant to cytotoxic chemotherapy. We present two mouse models of kidney cancer that recapitulate the genomic alterations found in human papillary (pRCC) and clear cell RCC (ccRCC), the most common RCC subtypes. MYC activation results in highly penetrant pRCC tumours (MYC), while MYC activation, when combined with Vhl and Cdkn2a (Ink4a/Arf) deletion (VIM), produce kidney tumours that approximate human ccRCC. RNAseq of the mouse tumours demonstrate that MYC tumours resemble Type 2 pRCC, which are known to harbour MYC activation. Furthermore, VIM tumours more closely simulate human ccRCC. Based on their high penetrance, short latency, and histologic fidelity, these models of papillary and clear cell RCC should be significant contributions to the field of kidney cancer research

San Francisco Hep B Free: A Grassroots Community Coalition to Prevent Hepatitis B and Liver Cancer

Chronic hepatitis B is the leading cause of liver cancer and the largest health disparity between Asian/Pacific Islanders (APIs) and the general US population. The Hep B Free model was launched to eliminate hepatitis B infection by increasing hepatitis B awareness, testing, vaccination, and treatment among APIs by building a broad, community-wide coalition. The San Francisco Hep B Free campaign is a diverse public/private collaboration unifying the API community, health care system, policy makers, businesses, and the general public in San Francisco, California. Mass-media and grassroots messaging raised citywide awareness of hepatitis B and promoted use of the existing health care system for hepatitis B screening and follow-up. Coalition partners reported semi-annually on activities, resources utilized, and system changes instituted. From 2007 to 2009, over 150 organizations contributed approximately $1,000,000 in resources to the San Francisco Hep B Free campaign. 40 educational events reached 1,100 healthcare providers, and 50% of primary care physicians pledged to screen APIs routinely for hepatitis B. Community events and fairs reached over 200,000 members of the general public. Of 3,315 API clients tested at stand-alone screening sites created by the campaign, 6.5% were found to be chronically infected and referred to follow-up care. A grassroots coalition that develops strong partnerships with diverse organizations can use existing resources to successfully increase public and healthcare provider awareness about hepatitis B among APIs, promote routine hepatitis B testing and vaccination as part of standard primary care, and ensure access to treatment for chronically infected individuals

Genomic, Pathway Network, and Immunologic Features Distinguishing Squamous Carcinomas

This integrated, multiplatform PanCancer Atlas study co-mapped and identified distinguishing molecular features of squamous cell carcinomas (SCCs) from five sites associated with smokin