Microglia Mediate Synaptic Material Clearance at the Early Stage of Rats With Retinitis Pigmentosa

Resident microglia are the main immune cells in the retina and play a key role in the pathogenesis of retinitis pigmentosa (RP). Many previous studies on the roles of microglia mainly focused on the neurotoxicity or neuroprotection of photoreceptors, while their contributions to synaptic remodeling of neuronal circuits in the retina of early RP remained unclarified. In the present study, we used Royal College of Surgeons (RCS) rats, a classic RP model characterized by progressive microglia activation and synapse loss, to investigate the constitutive effects of microglia on the synaptic lesions and ectopic neuritogenesis. Rod degeneration resulted in synapse disruption and loss in the outer plexiform layer (OPL) at the early stage of RP. Coincidentally, the resident microglia in the OPL increased phagocytosis and mainly engaged in phagocytic engulfment of postsynaptic mGluR6 of rod bipolar cells (RBCs). Complement pathway might be involved in clearance of postsynaptic elements of RBCs by microglia. We pharmacologically deleted microglia using a CSF1 receptor (CSF1R) inhibitor to confirm this finding, and found that it caused the accumulation of postsynaptic mGluR6 levels and increased the number and length of ectopic dendrites in the RBCs. Interestingly, the numbers of presynaptic sites expressing CtBP2 and colocalized puncta in the OPL of RCS rats were not affected by microglia elimination. However, sustained microglial depletion led to progressive functional deterioration in the retinal responses to light in RCS rats. Based on our results, microglia mediated the remodeling of RBCs by phagocytosing postsynaptic materials and inhibiting ectopic neuritogenesis, contributing to delay the deterioration of vision at the early stage of RP

Study of J/psi decays to Lambda Lambdabar and Sigma0 Sigma0bar

The branching ratios and Angular distributions for J/psi decays to Lambda Lambdabar and Sigma0 Sigma0bar are measured using BESII 58 million J/psi.Comment: 11 pages, 5 figure

Search for psi(3770)\ra\rho\pi at the BESII detector at the Beijing Electron-Positron Collider

Non-$D\bar{D}$ decay \psppto \rhopi is searched for using a data sample of $(17.3\pm 0.5) pb^{-1}$ taken at the center-of-mass energy of 3.773 GeV by the BESII detector at the BEPC. No \rhopi signal is observed, and the upper limit of the cross section is measured to be \sigma(\EETO \rhopi)<6.0 pb at 90% C. L. Considering the interference between the continuum amplitude and the \pspp resonance amplitude, the branching fraction of \pspp decays to $\rho\pi$ is determined to be \BR(\pspp\ra\rho\pi)\in(6.0\times10^{-6}, 2.4\times10^{-3}) at 90% C. L. This is in agreement with the prediction of the $S$- and $D$-wave mixing scheme of the charmonium states for solving the ``\rhopi puzzle'' between \jpsi and \psp decays.Comment: 15 pages, 5 figure

Measurement of the cross section for e^+e^- -> ppbar at center-of-mass energies from 2.0 to 3.07 GeV

Cross sections for e^+e^- -> ppbar have been measured at 10 center-of-mass energies from 2.0 to 3.07 GeV by the BESII experiment at the BEPC, and proton electromagnetic form factors in the time-like region have been determined.Comment: 6 pages, 3 figure

Partial Wave Analysis of χc0→π+π−K+K−\chi_{c0}\to\pi^+\pi^-K^+K^-

A partial wave analysis of $\chi_{c0}\to\pi^+\pi^-K^+K^-$ in $\psi(2S)\to\gamma\chi_{c0}$ decay is presented using a sample of 14 million $\psi(2S)$ events accumulated by the BES II detector. The data are fitted to the sum of relativistic covariant tensor amplitudes for intermediate resonant decay modes. From the fit, significant contributions to $\chi_{c0}$ decays from the channels $f_0(980)f_0(980)$, $f_0(980)f_0(2200)$, $f_0(1370)f_0(1710)$, $K^*(892)^0\bar K^*(892)^0$, $K^*_0(1430)\bar K^*_0(1430)$, $K^*_0(1430)\bar K^*_2(1430) + c.c.$, and $K_1(1270)K$ are found. Flavor-SU(3)-violating $K_1(1270)-K_1(1400)$ asymmetry is observed. Values obtained for the masses and widths of the resonances $f_0(1710)$, $f_0(2200)$, $f_0(1370)$, and $K^*_0(1430)$ are presented.Comment: 16 pages, 9 figures, and 4 table

Measurements of the cross sections for e+e−→hadronse^+e^- \to {\rm hadrons} at 3.650, 3.6648, 3.773 GeV and the branching fraction for ψ(3770)→non−DDˉ\psi(3770)\to {\rm non-}D\bar D

Using the BES-II detector at the BEPC Collider, we measured the lowest order cross sections and the $R$ values ($R=\sigma^0_{e^+e^- \to {\rm hadrons}}/\sigma^0_{e^+e^- \to \mu^+\mu^-}$) for inclusive hadronic event production at the center-of-mass energies of 3.650 GeV, 3.6648 GeV and 3.773 GeV. The results lead to $\bar R_{uds}=2.224\pm 0.019\pm 0.089$ which is the average of these measured at 3.650 GeV and 3.6648 GeV, and $R=3.793\pm 0.037 \pm 0.190$ at $\sqrt{s}=3.773$ GeV. We determined the lowest order cross section for $\psi(3770)$ production to be $\sigma^{\rm B}_{\psi(3770)} = (9.575\pm 0.256 \pm 0.813)~{\rm nb}$ at 3.773 GeV, the branching fractions for $\psi(3770)$ decays to be $BF(\psi(3770) \to D^0\bar D^0)=(48.9 \pm 1.2 \pm 3.8)$, $BF(\psi(3770) \to D^+ D^-)=(35.0 \pm 1.1 \pm 3.3)$ and $BF(\psi(3770) \to D\bar{D})=(83.9 \pm 1.6 \pm 5.7)$, which result in the total non-$D\bar D$ branching fraction of $\psi(3770)$ decay to be $BF(\psi(3770) \to {\rm non}-D\bar D)=(16.1 \pm 1.6 \pm 5.7)$.Comment: 11 pages, 5 figure

Measurements of the continuum RudsR_{\rm uds} and RR values in e+e−e^+e^- annihilation in the energy region between 3.650 and 3.872 GeV

We report measurents of the continuum $R_{\rm uds}$ near the center-of-mass energy of 3.70 GeV, the $R_{{\rm uds(c)}+\psi(3770)}(s)$ and the $R_{\rm had}(s)$ values in $e^+e^-$ annihilation at 68 energy points in the energy region between 3.650 and 3.872 GeV with the BES-II detector at the BEPC Collodier. We obtain the $R_{\rm uds}$ for the continuum light hadron (containing u, d and s quarks) production near the $D\bar D$ threshold to be $R_{\rm uds}=2.141 \pm 0.025 \pm 0.085$.Comment: 5 pages, 3 figure

Measurements of the braching fractions for psi(3770)--> D0D0-bar,D+D-,DD-bar$ and the resonance parameters of psi(3770) and psi(2S)

We report measurements of the branching fractions for $\psi(3770)\to D^0 \bar D^0, D^+D^-, D\bar D$ and resonance parameters of $\psi(3770)$ and $\psi(2S)$. By analyzing the line-shapes of the cross sections for inclusive hadron, $D^0 \bar D^0$ and $D^+D^-$ event production in the range from 3.660 GeV to 3.872 GeV covering both $\psi(2S)$ and $\psi(3770)$ resonances, we extract the branching fractions for $\psi(3770)$ decay into $D^0\bar D^0 {\rm and} D^+D^-$ respectively to be $B(\psi(3770)\to D^0 \bar D^0)=(46.7 \pm 4.7 \pm 2.3)$ and $B(\psi(3770)\to D^+ D^-)=(36.9 \pm 3.7 \pm 2.8)$, which give $B(\psi(3770)\to D \bar D)=(83.6 \pm 7.3 \pm 4.2)$ and non-$D\bar D$ branching fraction of $\psi(3770)$ to be $B(\psi(3770)\to non-D \bar D)=(16.4 \pm 7.3 \pm 4.2)$. We meanwhile obtain the resonance parameters of $\psi(3770)$ and $\psi(2S)$ to be $M_{\psi(3770)}=3772.2 \pm 0.7 \pm 0.3$ MeV, $\Gamma^{\rm tot}_{\psi(3770)}=26.9 \pm 2.4 \pm 0.3$ MeV and $\Gamma^{ee}_{\psi(3770)}=251 \pm 26 \pm 11$ eV; $M_{\psi(2S)}=3685.5 \pm 0.0 \pm 0.3$ MeV, $\Gamma^{\rm tot}_{\psi(2S)}=331 \pm 58 \pm 2$ keV and $\Gamma^{ee}_{\psi(2S)}=2.330 \pm 0.036 \pm 0.110$ keV; as well as the $R$ value for the light hadron production directly through one photon annihilation to be $R_{uds}=2.262\pm 0.054\pm 0.109$ in this energy region.Comment: 7 pages, 4 figure

Observation of a resonance X(1835) in J/\psi --> \gamma \pi^+ \pi^- \eta^{\prime}

The decay channel J/\psi --> \gamma \pi^+ \pi^- \eta^{\prime} is analyzed using a sample of 5.8\times 10^7 J\psi events collected with the BESII detector. A resonance, the X(1835), is observed in the \pi^+ \pi^- \eta^{\prime} invariant mass spectrum with a statistical significance of 7.7 \sigma. A fit with a Breit-Wigner function yields a mass M = 1833.7 \pm 6.1(stat) \pm 2.7(syst) MeV/c^2, a width \Gamma = 67.7 \pm 20.3(stat) \pm 7.7(syst) MeV/c^2 and a product branching fraction B(J/\psi --> \gamma X) B(X --> \pi^+ \pi^- \eta^{\prime}) = (2.2 \pm 0.4(stat) \pm 0.4(syst)) \times 10^{-4}. The mass and width of the X(1835) are not compatible with any known meson resonance. Its properties are consistent with expectations for the state that produces the strong p\bar{p} mass threshold enhancement observed in the J\psi -->\gamma p \bar{p} process at BESII.Comment: 5 pages, 3 figures, RevTex4, Submitted to Phys. Rev. Let