Plane grid structure damage location identification by model curvature

AbstractThe mode curvature is good identification effect for one-dimensional beam damage location. The whole plane grid structure modal shape similar to 2D bending plate, also similar to beam in each dimension, therefore, the beam damage location identification by curvature mode method can be improved for plane grid structure. The damage location identification method is established by computation and integration the two directions of the damaged structure modal curvature changes. Through the simulation examples proved the feasibility of this method

Strong association of lumbar disk herniation with diabetes mellitus: a 12-year nationwide retrospective cohort study

BackgroundDespite reports on the association between diabetes mellitus (DM) and lumbar disk herniation (LDH), large-scale, nationwide studies exploring this relationship are lacking. We aimed to examine the profiles of DM in individuals with LDH and explore the potential mechanisms underlying the development of these disorders.MethodsThis retrospective, population-based study was conducted between 2008 and 2019 using data from the National Health Insurance (NHI) research database in Taiwan. The primary outcome was the date of initial LDH diagnosis, death, withdrawal from the NHI program, or end of the study period.ResultsIn total, 2,662,930 individuals with and 16,922,546 individuals without DM were included in this study; 719,068 matched pairs were established following propensity score matching (1:1 ratio) for sex, age, comorbidities, smoking, alcohol consumption, antihyperglycemic medications, and index year. The adjusted risk for developing LDH was 2.33-fold (95% confidence interval: 2.29−2.37; P<0.001), age-stratified analysis revealed a significantly greater risk of LDH in every age group, and both males and females were approximately twice as likely to develop LDH in the DM compared with non-DM cohort. Individuals with DM and comorbidities had a significantly higher risk of developing LDH than those without, and the serial models yielded consistent results. Treatment with metformin, sulfonylureas, meglitinides, thiazolidinediones, dipeptidyl peptidase-4 inhibitors, or alpha-glucosidase inhibitors was associated with a more than 4-fold increased risk of LDH in the DM cohort. DM was strongly associated with the long-term development of LDH; over the 12-year follow-up period, the cumulative risk of LDH was significantly higher in patients with than without DM (log-rank P<0.001).ConclusionDM is associated with an increased risk of LDH, and advanced DM may indicate a higher risk of LDH

A system-level mechanistic investigation of traditional Chinese medicine, Yinlai Decoction, for related diseases

Purpose: To systemically explore the pharmacological mechanisms of traditional Chinese medicine, Yinlai Decoction (YD), used in the clinical management of pediatric diseases such as pneumonia and recurrent respiratory tract infections.Methods: An ingredient-target-disease database of YD was constructed using Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). First, the molecular targets related to lung and stomach diseases were searched and screened to avoid duplication. Second, the associations between these molecular targets were evaluated via Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and Gene Ontology (GO) and Pathway enrichment analysis in STRING.Results: A total of 627 chemical ingredients and 654 protein targets in YD were obtained. After further screening, 38 molecular targets linked to respiratory diseases, inflammatory responses and various infections were identified. Finally, 576 GO terms and 75 KEGG pathway terms were obtained by analyzing gene functional annotation clusters and abundance value of these targets. Most of these terms were closely related to the inflammatory response.Conclusion: Based on these in silico findings, the use of YD for treating respiratory diseases, inflammation and various infections, most probably via the suppression of inflammation, has been established. The approach adopted in this study can serve as a model methodology to develop an innovative TCM candidate drug at a network pharmacology level.Keywords: Yinlai Decoction, Network (System) pharmacology, Inflammation, Interacting genes/proteins, Gene ocntology, Pathway enrichment analysi