Engineering Illustrations of Correcting Building Inclination by Stress Redistribution Method

By drilling large diameter holes in foundation soil and digging out soils to release (or redistribute) lateral stress in subsoil so as to create new settlement, a new method, which is called stress redistribution method, has been developed for correcting inclined building on soft foundation soil. Using this method, tens buildings with inclination up to 1-2% have been corrected and resumed their normal function in Wuhan, China. Some typical case histories are selected to illustrate the sensitive, controllable, and reliable characteristics of this method. The technical problems encountered in correcting process, such as the induced settlement, its influence on neighbour building, the digging scheme adopted, etc., are analysed. Two operating procedure have been summarized based on the practice of correcting. Lastly, the possibility of correcting the inclination of the tower of Pisa is discussed

Optimal fuzzy iterative learning control based on artificial bee colony for vibration control of piezoelectric smart structures

Combining P-type iterative learning (IL) control, fuzzy logic control and artificial bee colony (ABC) algorithm, a new optimal fuzzy IL controller is designed for active vibration control of piezoelectric smart structures. In order to accelerate the learning speed of feedback gain, the fuzzy logic controller is integrated into the ANSYS finite element (FE) models by using APDL (ANSYS Parameter Design Language) approach to adjust adaptively the learning gain of P-type IL control. For improving the performance and robustness of the fuzzy logic controller as well as diminishing human intervention in the operation process, ABC algorithm is used to automatically identify the optimal configurations for values in fuzzy query table, fuzzification parameters and defuzzification parameters, and the main program of ABC algorithm is operated in MATLAB. The active vibration equations are driven from the FE equations for the dynamic response of a linear elastic piezoelectric smart structure. Considering the vibrations generated by various external disturbances, the optimal fuzzy IL controller is numerically investigated for a clamped piezoelectric smart plate. Results demonstrate that the proposed control approach makes the feedback gain has a fast learning speed and performs excellent in vibration suppression. This is demonstrated in the results by comparing the new control approach with the P-type IL control

Withaferin A induces apoptosis in rat C6 glioma cells through regulating NF-ΚB nuclear translocation and activation of caspase cascade

Background: The demand for the chemopreventive drug from the plant source is increasing in recent times, owing to its various biological activities without any adverse effect. The intention of this current study was to examine the antiglioma effect of Withaferin A (WFA) on C6 glioma cell line model.Materials and Methods: C6 glioma cells were administrated with different concentration of WFA (50, 100, 200 and 500 μg/mL) and DMSO (control) group to examine its anti-proliferative, anti-inflammatory and pro-apoptotic activities.Results: Treatment with WFA showed a significant decline in the glioma cell count in a dose-dependent manner and thus proving its anti-proliferative effect. Similarly, inflammatory markers were also substantially lowered upon treatment with different concentration of WFA. However, DNA fragmentation and apoptotic markers like Caspase-3 and 9 were concomitantly enhanced after co-cultured with different concentration of WFA and thus exhibiting its cytotoxicity efficacy. Furthermore, the protein expression of Bcl2 and Bax were markedly downregulated and upregulated respectively; upon treatment with WFA on C6 glioma cells.Conclusion: The outcome of this study evidently demonstrates that C6 glioma cells co-cultured with increased concentration of WFA, showed an anti-proliferative, anti-inflammatory and pro-apoptotic effect in a dose-dependent fashion.Keywords: Withaferin A, C6 glioma cells, anti-proliferative, anti-inflammatory, caspase, apoptosi

Inhibition of nuclear factor-kappa B enhances the tumor growth of ovarian cancer cell line derived from a low-grade papillary serous carcinoma in p53-independent pathway

Background: NF-kB can function as an oncogene or tumor suppressor depending on cancer types. The role of NF-kB in low-grade serous ovarian cancer, however, has never been tested. We sought to elucidate the function of NF-kB in the low-grade serous ovarian cancer. Methods: The ovarian cancer cell line, HOC-7, derived from a low-grade papillary serous carcinoma. Introduction of a dominant negative mutant, IkBαM, which resulted in decrease of NF-kB function in ovarian cancer cell lines. The transcription ability, tumorigenesis, cell proliferation and apoptosis were observed in derivative cell lines in comparison with parental cells. Results: Western blot analysis indicated increased expression of the anti-apoptotic proteins Bcl-xL and reduced expression of the pro-apoptotic proteins Bax, Bad, and Bid in HOC-7/IĸBαM cell. Further investigations validate this conclusion in KRAS wildtype cell line SKOV3. Interesting, NF-kB can exert its pro-apoptotic effect by activating mitogen-activated protein kinase (MAPK) phosphorylation in SKOV3 ovarian cancer cell, whereas opposite changes detected in p-MEK in HOC-7 ovarian cancer cell, the same as some chemoresistant ovarian cancer cell lines. In vivo animal assay performed on BALB/athymic mice showed that injection of HOC-7 induced subcutaneous tumor growth, which was completely regressed within 7 weeks. In comparison, HOC-7/IĸBαM cells caused sustained tumor growth and abrogated tumor regression, suggesting that knock-down of NF-kB by IĸBαM promoted sustained tumor growth and delayed tumor regression in HOC-7 cells. Conclusion: Our results demonstrated that NF-kB may function as a tumor suppressor by facilitating regression of low grade ovarian serous carcinoma through activating pro-apoptotic pathways

Photon blockade with a trapped Λ\Lambda-type three-level atom in asymmetrical cavity

We propose a scheme to manipulate strong and nonreciprocal photon blockades in asymmetrical Fabry-Perot cavity with a $\Lambda$-type three-level atom. Utilizing the mechanisms of both conventional and unconventional blockade, the strong photon blockade is achieved by the anharmonic eigenenergy spectrum brought by $\Lambda$-type atom and the destructive quantum interference effect induced by a microwave field. By optimizing the system parameters, the manipulation of strong photon blockade over a wide range of cavity detuning can be realized. Using spatial symmetry breaking introduced by the asymmetry of cavity, the direction-dependent nonreciprocal photon blockade can be achieved, and the nonreciprocity can reach the maximum at optimal cavity detuning. In particular, manipulating the occurring position of nonreciprocal photon blockade can be implemented by simply adjusting the cavity detuning. Our scheme provides feasible access for generating high-quality nonreciprocal single-photon sources

Economic Evaluation of Treating Herpes Zoster with Various Methods of Acupuncture and Moxibustion

AbstractObjectiveTo analyze the cost effect of surrounding acupuncture plus electric acupuncture, cotton-sheet moxibustion, puncturing with red-hot needles, tapping plus cupping on herpes zoster.MethodsFive hundred patients with herpes zoster were randomly divided into group A (surrounding acupuncture plus electric acupuncture), group B (cotton-sheet moxibustion), group C (puncturing with red-hot needles), group D (tapping plus cupping), and group E (Western medicine). The treatment was carried out twice a day in group E and once a day in the other four groups. The curative effect was observed on the 10th day of treatment; the cost was calculated for the five therapies, and the cost-effect ratio (C/E) and increment ratio (ΔC/ΔE) were analyzed.ResultsAfter the 10-day treatment, there was no statistical difference (P>0.05) in the curative effect among the five groups. Pain being alleviated one day faster than in group E amounted to a saving of RMB 21.90 yuan in group A, a saving of RMB 21.87 yuan in group B, a saving of RMB 26.00 yuan in group C, and a saving of RMB 20.23 yuan in group D. Compared with group C, the values of ΔC/ΔE were RMB 1.55, 2.81, and 0.21 yuan in groups A, B, and D, respectively.ConclusionsThe curative effect in groups A, B, C, and D was similar to that in group E, but the C/E was better than in group E

Nonideal MHD Simulation of HL Tau Disk: Formation of Rings

Recent high-resolution observations unveil ring structures in circumstellar disks. The origin of these rings has been widely investigated under various theoretical scenarios. In this work we perform global 3D nonideal MHD simulations including effects from both ohmic resistivity and ambipolar diffusion (AD) to model the HL Tau disk. The nonideal MHD diffusion profiles are calculated based on the global dust evolution calculation including sintering effects. Disk ionization structure changes dramatically across the snow line due to the change of dust size distribution close to the snow line of major volatiles. We find that accretion is mainly driven by disk wind. Gaps and rings can be quickly produced from different accretion rates across the snow line. Furthermore, AD leads to highly preferential accretion at the midplane, followed by magnetic reconnection. This results in a local zone of decretion that drains the mass in the field reconnection area, which leaves a gap and an adjacent ring just outside of it. Overall, under favorable conditions, both snow lines and nonideal MHD effects can lead to gaseous gaps and rings in protoplanetary disks