Systematic Determination of Absolute Absorption Cross-section of Individual Carbon Nanotubes

Determination of optical absorption cross-section is always among the central importance of understanding a material. However its realization on individual nanostructures, such as carbon nanotubes, is experimentally challenging due to the small extinction signal using conventional transmission measurements. Here we develop a technique based on polarization manipulation to enhance the sensitivity of single-nanotube absorption spectroscopy by two-orders of magnitude. We systematically determine absorption cross-section over broad spectral range at single-tube level for more than 50 chirality-defined single-walled nanotubes. Our data reveals chirality-dependent one-dimensional photo-physics through the behaviours of exciton oscillator strength and lifetime. We also establish an empirical formula to predict absorption spectrum of any nanotube, which provides the foundation to determine quantum efficiencies in important photoluminescence and photovoltaic processes

Experiment on separated layer rock failure technology for stress reduction of entry under coal pillar in mining conditions

Longwall entrance is especially vulnerable to the combined mining of nearby coal seams because of the substantial deformation disaster loaded by the abutment stress caused by the mining disturbance. Changes to the fracture characteristics, movement behavior, and structural morphology of the bearing structure above the coal pillar are recommended using the separated layer rock failure technology (SLRFT) to safeguard the entry beneath the coal pillar from high abutment stress. To simulate the impacts of the SLRFT on the decrease of the abutment stress surrounding the entry under the coal pillar under the plane–stress circumstances, two experimental models were created. Abutment stress revolution, roof movement laws, and fracture features were all tracked using three identical monitoring systems in each experimental model. The experimental results indicate that SLRFT generates the shorter caving step length, more layered collapse, and higher caving height of the immediate roof, which improves the dilatancy of caving rock mass, the filling rate, and the compaction degree of the worked-out area. In the ceiling above the worked-out area, the fracture progresses from a non-penetrating horizontal and oblique gaping fracture to stepped closed fractures and piercing fractures. The main roof’s subsidence shifts from a linear, slow tendency to a stepped, fast one. The bearing structure changes from two-side cantilever structure with a T type into one-side cantilever structure with a basin type. Because the compacted worked-out region has a bigger support area, more of the overburden load is transferred there, weakening the abutment stress around the longwall entry from 12.5 kPa to 3.7 kPa. The stress reduction degree increases with the reduction of the cantilever length of the bearing structure and the increasing of the support coefficient of the compacted worked-out area. These findings illustrate the effectiveness of SLRFT in lowering entrance stress. With the established experimental model, it is possible to evaluate the viability, efficiency, and design of SLRFT under various engineering and geological circumstances

Case report: long-term sustained remission in a case of metastatic colon cancer with high microsatellite instability and KRAS exon 2 p.G12D mutation treated with fruquintinib after local radiotherapy: a case report and literature review

To demonstrate the efficacy of fruquintinib administration after local radiotherapy in a patient with metastatic colon cancer with high microsatellite instability and the KRAS exon 2 p. G12D mutation. The patient was administered four cycles of pembrolizumab intravenous infusion and achieved stable disease as the best outcome. He was then underwent follow-up concurrent radiochemical therapy (local DT4600cGy/23f/32d radiotherapy, and S-1 to increase sensitivity to radiotherapy), but this had little efficacy. Following this, he was administered fruquintinib and achieved sustained partial remission. At the time of last follow-up, the patient was in continuous remission for 30 months. Administration of fruquintinib after local radiotherapy may be an effective treatment for specific populations with metastatic colorectal cancer

Ubiquitin-Specific Peptidase 10 (USP10) Deubiquitinates and Stabilizes MutS Homolog 2 (MSH2) to Regulate Cellular Sensitivity to DNA Damage

MSH2 is a key DNA mismatch repair protein, which plays an important role in genomic stability. In addition to its DNA repair function, MSH2 serves as a sensor for DNA base analogs-provoked DNA replication errors and binds to various DNA damage-induced adducts to trigger cell cycle arrest or apoptosis. Loss or depletion of MSH2 from cells renders resistance to certain DNA-damaging agents. Therefore, the level of MSH2 determines DNA damage response. Previous studies showed that the level of MSH2 protein is modulated by the ubiquitin-proteasome pathway, and histone deacetylase 6 (HDAC6) serves as an ubiquitin E3 ligase. However, the deubiquitinating enzymes, which regulate MSH2 remain unknown. Here we report that ubiquitin-specific peptidase 10 (USP10) interacts with and stabilizes MSH2. USP10 deubiquitinates MSH2 in vitro and in vivo. Moreover, the protein level of MSH2 is positively correlated with the USP10 protein level in a panel of lung cancer cell lines. Knockdown of USP10 in lung cancer cells exhibits increased cell survival and decreased apoptosis upon the treatment of DNA-methylating agent N-methyl-N′-nitro-N-nitrosoguanidine (MNNG) and antimetabolite 6-thioguanine (6-TG). The above phenotypes can be rescued by ectopic expression of MSH2. In addition, knockdown of MSH2 decreases the cellular mismatch repair activity. Overall, our results suggest a novel USP10-MSH2 pathway regulating DNA damage response and DNA mismatch repair

An efficient deadlock prevention approach for service oriented transaction processing

Transaction processing can guarantee the reliability of business applications. Locking resources is widely used in distributed transaction management (e.g., two phase commit, 2PC) to keep the system consistent. The locking mechanism, however, potentially results in various deadlocks. In service oriented architecture (SOA), the deadlock problem becomes even worse because multiple (sub)transactions try to lock shared resources in the unexpectable way due to the more randomicity of transaction requests, which has not been solved by existing research results. In this paper, we investigate how to prevent local deadlocks, caused by the resource competition among multiple sub-transactions of a global transaction, and global deadlocks from the competition among different global transactions. We propose a replication based approach to avoid the local deadlocks, and a timestamp based approach to significantly mitigate the global deadlocks. A general algorithm is designed for both local and global deadlock prevention. The experimental results demonstrate the effectiveness and efficiency of our deadlock prevention approach. Further, it is also proved that our approach provides higher system performance than traditional resource allocation schemes. © 2011 Elsevier Ltd. All rights reserved.link_to_subscribed_fulltex