Deodorants and antiperspirants: New trends in their active agents and testing methods

Sweating is the human body's thermoregulation system but also results in unpleasant body odour which can diminish the self-confidence of people. There has been continued research in finding solutions to reduce both sweating and body odour. Sweating is a result of increased sweat flow and malodour results from certain bacteria and ecological factors such as eating habits. Research on deodorant development focuses on inhibiting the growth of malodour-forming bacteria using antimicrobial agents, whereas research on antiperspirant synthesis focuses on technologies reducing the sweat flow, which not only reduces body odour but also improves people's appearance. Antiperspirant's technology is based on the use of aluminium salts which can form a gel plug at sweat pores, obstructing the sweat fluid from arising onto the skin surface. In this paper, we perform a systematic review on the recent progress in the development of novel antiperspirant and deodorant active ingredients that are alcohol-free, paraben-free, and naturally derived. Several studies have been reported on the alternative class of actives that can potentially be used for antiperspirant and body odour treatment including deodorizing fabric, bacterial, and plant extracts. However, a significant challenge is to understand how the gel-plugs of antiperspirant actives are formed in sweat pores and how to deliver long-lasting antiperspirant and deodorant benefits without adverse health and environmental effects

Programmable base editing of zebrafish genome using a modified CRISPR-Cas9 system.

Precise genetic modifications in model animals are essential for biomedical research. Here, we report a programmable "base editing" system to induce precise base conversion with high efficiency in zebrafish. Using cytidine deaminase fused to Cas9 nickase, up to 28% of site-specific single-base mutations are achieved in multiple gene loci. In addition, an engineered Cas9-VQR variant with 5'-NGA PAM specificities is used to induce base conversion in zebrafish. This shows that Cas9 variants can be used to expand the utility of this technology. Collectively, the targeted base editing system represents a strategy for precise and effective genome editing in zebrafish.The use of base editing enables precise genetic modifications in model animals. Here the authors show high efficient single-base editing in zebrafish using modified Cas9 and its VQR variant with an altered PAM specificity

SoC-Tuner: An Importance-guided Exploration Framework for DNN-targeting SoC Design

Designing a system-on-chip (SoC) for deep neural network (DNN) acceleration requires balancing multiple metrics such as latency, power, and area. However, most existing methods ignore the interactions among different SoC components and rely on inaccurate and error-prone evaluation tools, leading to inferior SoC design. In this paper, we present SoC-Tuner, a DNN-targeting exploration framework to find the Pareto optimal set of SoC configurations efficiently. Our framework constructs a thorough SoC design space of all components and divides the exploration into three phases. We propose an importance-based analysis to prune the design space, a sampling algorithm to select the most representative initialization points, and an information-guided multi-objective optimization method to balance multiple design metrics of SoC design. We validate our framework with the actual very-large-scale-integration (VLSI) flow on various DNN benchmarks and show that it outperforms previous methods. To the best of our knowledge, this is the first work to construct an exploration framework of SoCs for DNN acceleration.Comment: ASP-DAC 202

Theoretical model and characteristics analysis of deflector-jet servo valve’s pilot stage

To analyze the deflector-jet servo valve’s internal flow characteristics, a theoretical model of the complicated flow distribution in the deflector plate is established based on the offset jet attachment theory. When the deflector plate offsets, jet attachment parameters are attained to figure out the jet’s bending and colliding process. On this basis, an analytical method of acquiring the pilot valve’s pressure gain is derived. According to an actual pilot stage’s structure, pressure gain calculations are carried out. Meanwhile, the pilot valve’s mesh model is established for numerical simulation in order to examine the accuracy of the theoretical model. Calculation and numerical simulation show that the final oil jet is not sensitive to the deflector plate’s movement, which directly reveals the pressure stabilizing effect of the V-shaped structure on the deflector plate. Moreover, the experiment on the pressure gain is accomplished and experiment results verify the accuracy of the analytical calculation