24 research outputs found
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The Surface Detector System of the Pierre Auger Observatory
The Pierre Auger Observatory is designed to study cosmic rays with energies greater than 10{sup 19} eV. Two sites are envisaged for the observatory, one in each hemisphere, for complete sky coverage. The southern site of the Auger Observatory, now approaching completion in Mendoza, Argentina, features an array of 1600 water-Cherenkov surface detector stations covering 3000 km{sup 2}, together with 24 fluorescence telescopes to record the air shower cascades produced by these particles. The two complementary detector techniques together with the large collecting area form a powerful instrument for these studies. Although construction is not yet complete, the Auger Observatory has been taking data stably since January 2004 and the first physics results are being published. In this paper we describe the design features and technical characteristics of the surface detector stations of the Pierre Auger Observatory
Boletim.
Publication suspended 1933-Sept. 1948.Mode of access: Internet.Issued 19 - by the Secretaria da Agricultura, Viacão, Industria e Obras Publicas (varies slightly)
The skilful physician containing directions for the preservation of a healthful condition, and approved remedies for all diseases and infirmities (outward or inward) incident to the body of man ... whereunto is added experimented instructions for the compounding of perfumes, also for the chusing and ordering of all kinds of wines, both in preserving the sound, and rectifying those that are prick'd : never before imparted to publick view.
Mycoplasma agalactiae Vaccines: Current Status, Hurdles, and Opportunities Due to Advances in Pathogenicity Studies
Contagious agalactia (CA) is a serious multietiological disease whose classic etiological agent is Mycoplasma agalactiae and which causes high morbidity and mortality rates in infected herds. CA is classified as a notifiable disease by the World Organization for Animal Health due to its significant worldwide economic impact on livestock, primarily involving goat and sheep farms. The emergence of atypical symptoms and strains of M. agalactiae in wildlife ungulates reestablishes its highly plastic genome and is also of great epidemiological significance. Antimicrobial therapy is the main form of control, although several factors, such as intrinsic antibiotic resistance and the selection of resistant strains, must be considered. Available vaccines are few and mostly inefficient. The virulence and pathogenicity mechanisms of M. agalactiae mainly rely on surface molecules that have direct contact with the host. Because of this, they are essential for the development of vaccines. This review highlights the currently available vaccines and their limitations and the development of new vaccine possibilities, especially considering the challenge of antigenic variation and dynamic genome in this microorganism