Searching for a Solar Source of Magnetic-Field Switchbacks in Parker Solar Probe’s First Encounter

Parker Solar Probe observations show ubiquitous magnetic-field reversals closer to the Sun, often referred to as “switchbacks”. The switchbacks have been observed before in the solar wind near 1 AU and beyond, but their occurrence was historically rare. PSP measurements below ∼ 0.2 AU show that switchbacks are, however, the most prominent structures in the “young” solar wind. In this work, we analyze remote-sensing observations of a small equatorial coronal hole to which PSP was connected during the perihelion of Encounter 1. We investigate whether some of the switchbacks captured during the encounter were of coronal origin by correlating common switchback in situ signatures with remote observations of their expected coronal footpoint. We find strong evidence that timescales present in the corona are relevant to the outflowing, switchback-filled solar wind, as illustrated by strong linear correlation. We also determine that spatial analysis of the observed region is optimal, as the implied average solar-wind speed more closely matches that observed by PSP at the time. We observe that hemispherical structures are strongly correlated with the radial proton velocity and the mass flux in the solar wind. The above findings suggest that a subpopulation of the switchbacks are seeded at the corona and travel into interplanetary space.Fil: De Pablos, D.. University College London; Estados UnidosFil: Samanta, T.. Indian Institute of Astrophysics; IndiaFil: Badman, S. T.. University of California at Berkeley; Estados UnidosFil: Schwanitz, C.. No especifíca;Fil: Bahauddin, S. M.. State University of Colorado at Boulder; Estados UnidosFil: Harra, L. K.. No especifíca;Fil: Petrie, G.. No especifíca;Fil: Mac Cormack, Cecilia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Mandrini, Cristina Hemilse. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Astronomía y Física del Espacio. - Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Astronomía y Física del Espacio; ArgentinaFil: Raouafi, N. E.. No especifíca;Fil: Martinez Pillet, V.. No especifíca;Fil: Velli, M.. University of California at Los Angeles; Estados Unido

Diagnostic workup including CD203c‐based basophil activation test in immediate hypersensitivity due to metronidazole and ornidazole and evaluation of cross‐reactivity in between

Background Little is known about the diagnostic approaches for immediate hypersensitivity reactions (IHRs) due to 5-nitroimidazole antibiotics. The aim was to evaluate the usefulness of in vivo tests and basophil activation test (BAT) for the diagnosis of IHRs due to metronidazole and ornidazole and to determine possible cross-reactivity in between. Methods Forty-nine patients with a clear history of IHRs due to these drugs and 20 healthy subjects who were known to tolerate these drugs were included. Skin tests (STs) and single-blind placebo-controlled drug provocation tests (SBPCDPTs) were performed with both drugs whereas BAT was applied only with the culprit drug. Results The most and least common reaction types were urticaria/angioedema (34.7%) and anaphylaxis (14.3%), respectively. SBPCDPTs were positive in 15 out of 47 patients, and only 7 had positive STs. Sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) of STs for metronidazole/ornidazole were 33.3%/16.6%, 94.2%/97.3%, 60%/50%, and 84.6%/88.1%, respectively. BAT was positive in 12 out of 15 patients and negative in 10 control subjects, giving a sensitivity rate of 71.4% (CI, 29.0%-96.3%) for metronidazole and 83.3% (CI, 35.8%-99.5%) for ornidazole. The optimal concentration of both drugs for BAT was determined as 5 mg/mL. No cross-reactivity among two drugs was observed according to in vivo tests. Conclusions Our study showed that SBPCDPT and BAT are both useful diagnostic tools for IHRs due to 5-nitroimidazole antibiotics and can be used as supplementary to each other. No cross-reactivity between metronidazole and ornidazole in IHRs exists

Recent advances in Surface Plasmon Resonance for biosensing applications and future prospects

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