Regeneration of Intrabony Defects with Nano Hydroxyapatite Graft, Derived from Eggshell along with Periosteum as Barrier Membrane under Magnification—An Interventional Study

Intrabony defects can be treated by various approaches. Use of GTR along with bone grafts is said to enhance the outcome. The periosteum has been claimed to increase the regeneration. The egg-shell-derived nano hydroxyapatite (EnHA) has shown a scope as alloplastic graft. Thus, the following study was undertaken to combine the periosteal pedicle along with EnHA for the treatment of intrabony defects under magnification to achieve optimal bone regeneration. A total of 21 patients, having intrabony defects with ≥6 mm probing depth (PD) and two or three wall defects as detected on CBCT, satisfying inclusion criteria were enrolled. The sites were randomly allocated as Group A, B and C (n = 7). The following parameters, defect density and defect fill in CBCT (at baseline and 6 months), PPD, RAL, Plaque index (PI), Gingival index (GI) and Gingival Bleeding Index (GBI) were recorded at baseline, 1, 3 and 6 months. p < 0.05 is considered as statistically significant. Bone density and bone fill values were found to be much higher in pedicle with EnHA and EnHA alone group and the values showed statistically significant results. The current clinical research showed that periosteal pedicle along with EnHA and EnHA as stand-alone therapy gave superior results compared to OFD alone, which is an innovative and feasible treatment option

Synthesis of temperature responsive biohybrid guar-based grafted copolymers by click chemistry

International audienceNovel thermoresponsive biohybrid guar-based grafted copolymers were prepared in aqueous medium by copper catalyzed 1,3-dipolar Huisgen cycloaddition between an α-butoxy-ω-azido-PEO-co-PPO derivative, characterized by LCST behavior, and guar gum bearing alkyne functionalities randomly distributed along the chain. The chemical pathway gives well-defined guar-g-(PEO-co-PPO) copolymers with tunable chemical compositions. The resulting grafted copolymers were shown to exhibit a reversible thermo-induced association leading to elastic physical network-like behaviors. It has been shown that the rheological properties are intimately related to the molecular weight and to the degree of substitution of guar. The temperature of association of the grafted copolymer is controlled by the cloud point of the grafted polyoxyalkylene and the salt concentration variation appeared as a very convenient manner to tune the thermoresponsive character without changing the chemical nature of the side-chains. Finally, in relation with macroscopic properties, the thermoassociative effect was monitored by NMR analysis

Not all Anionic Polyelectrolytes complex with DTAB

Yuguo Cui, Robert Pelton, Terence Cosgrove, Robert Richardson, Sheng Dai, Stuart Prescott, Isabelle Grillo, Howard Ketelson and David Meadow