Thromboembolism in inflammatory bowel diseases: a report from Saudi Arabia

Thromboembolism (TE) is a serious but under-recognized complication of inflammatory bowel disease (IBD). This is specially so in developing countries where the incidence of IBD is low. In Saudi Arabia, IBD is considered to be rare, but the incidence is increasing. Where the clinical manifestations resemble those of developed countries, TE as a complication of IBD is considered to be very rare. This report describes six IBD patients with TE. This importance of the complication of TE is stressed, and physicians caring for these patients should be aware of it in order to obviate potential morbidity and mortality

Twelve-month observational study of children with cancer in 41 countries during the COVID-19 pandemic

Introduction Childhood cancer is a leading cause of death. It is unclear whether the COVID-19 pandemic has impacted childhood cancer mortality. In this study, we aimed to establish all-cause mortality rates for childhood cancers during the COVID-19 pandemic and determine the factors associated with mortality. Methods Prospective cohort study in 109 institutions in 41 countries. Inclusion criteria: children <18 years who were newly diagnosed with or undergoing active treatment for acute lymphoblastic leukaemia, non-Hodgkin's lymphoma, Hodgkin lymphoma, retinoblastoma, Wilms tumour, glioma, osteosarcoma, Ewing sarcoma, rhabdomyosarcoma, medulloblastoma and neuroblastoma. Of 2327 cases, 2118 patients were included in the study. The primary outcome measure was all-cause mortality at 30 days, 90 days and 12 months. Results All-cause mortality was 3.4% (n=71/2084) at 30-day follow-up, 5.7% (n=113/1969) at 90-day follow-up and 13.0% (n=206/1581) at 12-month follow-up. The median time from diagnosis to multidisciplinary team (MDT) plan was longest in low-income countries (7 days, IQR 3-11). Multivariable analysis revealed several factors associated with 12-month mortality, including low-income (OR 6.99 (95% CI 2.49 to 19.68); p<0.001), lower middle income (OR 3.32 (95% CI 1.96 to 5.61); p<0.001) and upper middle income (OR 3.49 (95% CI 2.02 to 6.03); p<0.001) country status and chemotherapy (OR 0.55 (95% CI 0.36 to 0.86); p=0.008) and immunotherapy (OR 0.27 (95% CI 0.08 to 0.91); p=0.035) within 30 days from MDT plan. Multivariable analysis revealed laboratory-confirmed SARS-CoV-2 infection (OR 5.33 (95% CI 1.19 to 23.84); p=0.029) was associated with 30-day mortality. Conclusions Children with cancer are more likely to die within 30 days if infected with SARS-CoV-2. However, timely treatment reduced odds of death. This report provides crucial information to balance the benefits of providing anticancer therapy against the risks of SARS-CoV-2 infection in children with cancer

ETUDE DE LA REGULATION TRANSCRIPTIONNELLE DE TIE-2. CLONAGE D'ECCO (UN NOUVEAU COFACTEUR D'OCT-1 EXPRIME DANS LES CELLULES ENDOTHELIALES)

PARIS7-Bibliothèque centrale (751132105) / SudocSudocFranceF

Effects of Soil Depth And Rivers Slop on Total Boron Content In Some of The Iraqi Provinces

Aiming to study effects of soil depth and rivers slop on total boron concentration in Middle Euphrates River Reion that represent in the sedimentary plain, soil pedon samples of cultivated territory that adjacent to rivers were taken. These regions are located in provinces of Karbala, Babylon, Najaf, Diwaniyah, and Al-Muthana. Ten soil pedon were taken of soils that adjacent to the main Euphrates River, the Al-Hilaa, and the AL-Daghara Rivers in these provinces. Soil pedon of soils that on the banks or close to the main Euphrates River were taken of counties of Twarije, Kufa, Gamas, and Al-Samawa. In the same way, soil pedon of Missaib, Hashmiah, Diwaniyah, and Rumitha are adjacent to the Hilla River and soil pedon of Al-Daghara and Affak belongs to the area of Al-Daghara River. Results show a reduction in total boron concentration for all of the tested soil pedon directly related with the depth. Aggregate boron concentration values are the highest at the surface layer and reduce as going depth except for soils of Al-Samawa and Al-Rumitha. Total boron concentration values are fluctuated between 1.033 mg. kg-1 and 14.658 mg. kg-1 in all of the studied soils. the results showed too the total boron values are not conducted with the tourmaline mineral percent in all sites.

Anomalous right coronary artery originating from the mid left anterior descending artery

A 68-year-old male with a history of hypertension and hypercholesterolemia presented with recurrent episodes of chest discomfort. A 12-lead ECG and an echocardiogram were normal. A myocardial perfusion study could not rule out ischemia in the inferior wall. At coronary angiography using the transradial approach, the right coronary artery (RCA) could not be visualized. Angiography of the left coronary system demonstrated non-obstructive atherosclerosis involving the mid segment of the left anterior descending (LAD) artery and a normal circumflex (Cx) artery. The RCA originated from the mid LAD segment distal to the first septal perforator and the first diagonal branch and was free of atherosclerosis disease. A contrast-enhanced 64-slice multi-detector cardiac computed tomography showed that the LAD was severely calcified in the proximal part, and the RCA coursed anterior to the right ventricular outflow tract (RVOT) to reach the right atrioventricular groove. The patient was managed medically and became asymptomatic

Massive pericardial effusion without cardiac tamponade

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