Association of vitamin D deficiency with ventricular repolarization abnormalities

Background: Vitamin D is involved in cardiac contractility and myocardial calcium hemostasis, and vitamin D deficiencies are known to cause various cardiovascular disorders and have been linked with sudden cardiac death. Aim: The aim of the study was to evaluate repolarization distribution, represented by QT interval, corrected QT interval (QTc), QT dispersion, Tpeak‑to‑Tend (Tp‑e) interval, Tp‑e/QTc ratio, JT interval, JT dispersion, and Tp‑e/JTpeak ratio in children with vitamin D deficiency. Moreover, we aimed to determine the relationship between ventricular repolarization anomalies and vitamin D deficiency. Methods: The study included 50 adolescent patients with vitamin D deficiency (vitamin D < 20 ng/ml), 50 adolescent patients with vitamin D insufficiency, and 50 age‑matched controls (vitamin D level > 30 ng/ml). QTc duration, QT dispersion, JTpeak duration, JT dispersion, Tp‑e, Tp‑e/JTpeak ratio, and Tp‑e/QTc ratio were recorded on electrocardiogram. Results: Patients with vitamin D deficiency or insufficiency had longer Tp‑e interval (P < 0.001), while Tp‑e/QTc and Tp‑e/JTpeak ratios were found to be increased in the same group of patients (P = 0.005 and P < 0.001, respectively). QT dispersion and JT dispersion were higher in the deficient group when compared with the other groups (P = 0.045 and P = 0.02, respectively). Conclusion: The present study, conducted in a pediatric population, is the first in the current literature to assess the relationship between ventricular repolarization anomalies and vitamin D deficiency

Gastrointestinal involvement in Kawasaki disease: a case report

WOS: 000439937200018PubMed: 29962358Kawasaki disease is an acute febrile multisystem vasculitis. the term Incomplete Kawasaki disease is used in the presence of a minimum of two diagnostic criteria of clinical Kawasaki syndrome accompanied by at least 5 days of fever, the absence of any other reasons characterising the disease, and the presence of severe systemic inflammation findings. Gastrointestinal symptoms, notably diarrhoea, abdominal pain, and vomiting, frequently occur, and elevated serum aminotransferases, gallbladder hydrops, and rarely other forms of gastrointestinal involvement such as ischaemic colitis, intussusception, hepatic necrosis, splenic infarct, intestinal pseudo-obstruction, colitis, and colon oedema are also reported. in this paper, we present an incomplete and atypical Kawasaki case that explicitly shows gastrointestinal involvement. Progressive bowel oedema was detected in the patient presenting with severe abdominal pain and distension. We determined an aneurysm in the right coronary artery and diffuse dilatation in the left main coronary artery despite administration of early intravenous immunoglobulin. in addition to the cardiac problem, hypoalbuminaemia, electrolyte imbalance, sterile pyuria, hepatosplenomegaly, and hydrops of the gallbladder were observed in the case. All findings, including progressive bowel oedema accompanying abdominal distension, improved markedly after the second dose of intravenous immunoglobulin