Stratigraphic columns for the Neogene succession exposed in central parts of Hawke’s Bay Basin, eastern North Island, New Zealand

This report is a compilation of stratigraphic columns for geological sections and outcrops of Neogene sedimentary units in central parts of Hawke’s Bay Basin, eastern North Island, New Zealand. The columns have been prepared as part of a basin analysis investigation undertaken by the Sedimentary and Petroleum Geology Research Group in the Department of Earth and Ocean Sciences at the University of Waikato and have been compiled into a common format from six recent MSc and PhD theses to make the information more readily available, principally to assist hydrocarbon exploration activities in the region. The columns represent a level of detail underpinning a rationalized lithostratigraphy of the Neogene basin fill. The systematic lithostratigraphic description of the basin fill is given in a companion report (Bland et al. 2007)

Assessing the social cost and benefits of a national requirement establishing antibiotic stewardship programs to prevent Clostridioides difficile infection in US hospitals

Abstract Backgound Economic evaluations of interventions to prevent healthcare-associated infections in the United States rarely take the societal perspective and thus ignore the potential benefits of morbidity and mortality risk reductions. Using new Department of Health and Human Services guidelines for regulatory impact analysis, we developed a cost-benefit analyses of a national multifaceted, in-hospital Clostridioides difficile infection prevention program (including staffing an antibiotic stewardship program) that incorporated value of statistical life estimates to obtain economic values associated with morbidity and mortality risk reductions. Methods We used a net present value model to assess costs and benefits associated with antibiotic stewardship programs. Model inputs included treatment costs, intervention costs, healthcare-associated Clostridioides difficile infection cases, attributable deaths, and the value of statistical life which was used to estimate the economic value of morbidity and mortality risk reductions. Results From 2015 to 2020, total net benefits of the intervention to the healthcare system range from $300 million to$7.6 billion when values for morbidity and mortality risk reductions are ignored. Including these values, the net social benefits of the intervention range from $21 billion to$624 billion with the annualized net benefit of $25.5 billion under our most likely outcome scenario. Conclusions Incorporating the economic value of morbidity and mortality risk reductions in economic evaluations of healthcare-associated infections will significantly increase the benefits resulting from prevention

The Ccr4a (CNOT6) and Ccr4b (CNOT6L) deadenylase subunits of the human Ccr4–Not complex contribute to the prevention of cell death and senescence

The human Ccr4-Not complex has two types of deadenylase subunits that shorten the polyadenylate tail of cytoplasmic mRNA. The authors present evidence for novel roles of the highly related Ccr4a/Ccr4b deadenylases in preventing cell death and senescence and show that they have distinct roles as compared with the Caf1a/Caf1b deadenylases