Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index as a reference criterion of risk for metabolic syndrome (MetS) and low insulin sensitivity in apparently healthy subjects

"Aim: To evaluate if the TG/HDL-C index can be considered as a reference criterion of MetS and low insulin sensitivity in apparently healthy subjects. Methods: The subjects were Mexican mestizos who resided in Puebla City, Mexico, who were anthropometrically, biochemically, and clinically characterized. The TG/HDL-C index was calculated by dividing triglyceride (TG) levels by HDL-C levels. MetS was diagnosed by the Third Report from the Adult Treatment Panel-National Cholesterol Education Program (ATP-III NCEP) criteria, while insulin sensitivity was evaluated by the Quantitative Insulin sensitivity Check Index (QUICKI). Results: The study included 813 subjects, with an average age of 38.6 ± 12.1 years, of which 564 were women and 249 men. An association was found between high TG/HDL-C index and low insulin sensitivity (Odds ratio [OR]: 4.09; p < 0.01) and with MetS (OR: 15.29; p < 0.01). A correlation was found between the TG/HDL-C index and QUICKI (rho: –0.4989; p < 0.01) and with MetS (rho: 0.6581; p < 0.01). Conclusion: The results indicate that the TG/HDL-C index is associated with low insulin sensitivity and MetS in apparently healthy subjects, suggesting this index as a reference criterion of risk for low insulin sensitivity and MetS"

Triglyceride/high-density lipoprotein cholesterol (TG/HDL-C) index as a reference criterion of risk for metabolic syndrome (MetS) and low insulin sensitivity in apparently healthy subjects

"The MetS involves a cluster of metabolic abnormalities including centrally distributed obesity, decreased concentration of high-density lipoprotein colesterol (HDL-C), elevated triglycerides (TG), high blood pressure, and hyperglycemia1. MetS is also a risk factor for developing type 2 diabetes mellitus (DM2), ischemic heart disease, and arteriosclerosis-associated stroke, which are causes of mortality1,2. Given the previously mentioned information, MetS is considered a public health problem worldwide, especially in Westernized countries1, presenting a prevalence of 39.7% in Mexico"

Relationship of triglycerides/high density lipoprotein-cholesterol index with antioxidant defense and outstanding association with high sensitive c-reactive protein in Mexican subjects

"The TriGlycerides/High-Density Lipoprotein- Cholesterol (TG/HDL-C) ratio is a new index that has been proposed to estimate CardioVascular Risk (CVR). However, the relationship between this index with the antioxidant defense and inflammation is unknown. The aim of the study was to determine the relationship between the TG/HDL-C index with antioxidant defense and inflammation marker in Mexican subjects. Materials and Methods: In the study, Mexican subjects participated who were anthropometrically, biochemically, and clinically characterized. The TG/HDL-C index was calculated by dividing TG levels by HDL-C levels; a cut-off point >3 was considered CVR. The study subjects were divided into three groups: 1) subjects without CVR; 2) subjects with CVR, and 3) subjects with Type 2 Diabetes (T2D). In the subjects, we evaluated antioxidant defense by determine SuperOxide Dismutase (SOD) and Glutathione Peroxidase (GPx) activities, and high sensitive C-Reactive Protein (hsCRP) as inflammation marker"

Relationship of triglycerides/high density lipoprotein-cholesterol index with antioxidant defense and outstanding association with high sensitive C-reactive protein in Mexican subjects

"Background: The TriGlycerides/High-Density Lipoprotein- Cholesterol (TG/HDL-C) ratio is a new index that has been proposed to estimate CardioVascular Risk (CVR). However, the relationship between this index with the antioxidant defense and inflammation is unknown. The aim of the study was to determine the relationship between the TG/HDL-C index with antioxidant defense and inflammation marker in Mexican subjects"

Dry eye disease association with computer exposure time among subjects with computer vision syndrome

"Purpose: To assess the time of exposure to the computer and dry eye disease (DED) in subjects with computer vision syndrome (CVS). Methods: A cross-sectional study was conducted in office workers, computer users of both sexes, with an age range of 18-45 years without comorbidities; we included 108 subjects divided into 3 groups according to the time of computer exposure in hours per day (H/D): 8 (n = 39). A specific questionnaire was applied to them on the exposure time and the type of visual display terminal (VDT) used, as well as the computer vision symptoms scale (CVSS17). DED was diagnosed with the Ocular Surface Disease Index (OSDI). Ocular surface damage and signs of DED were evaluated with the tear rupture time test (TBUT), the integrity of the ocular surface by ocular surface staining (OSS) and the production of the aqueous basal tear film using the Schirmer test"

Dry eye disease association with computer exposure time among subjects with computer vision syndrome

"Computer vision syndrome (CVS) is defined as “The combination of eye problems and vision, associated with prolonged use of computers.”1 This term is used to describe the collection of visual, ocular and musculoskeletal symptoms that result from prolonged computer or visual display terminal (VDT) use. It may develop when a computer is used >3 hours per day or >30 hours per week.1,2 It is characterized by constant symptoms ocular, visual and musculoskeletal as asthenopia, ocular surface alterations, visual and extra-ocular alterations.1–4 It can be diagnosed in a standardized and reliable way with the computer-vision symptom scale questionnaire (CVSS17).5 This questionnaire include encompasses 15 visual and ocular symptoms as well as ocular surface alterations include dry, red, wet or irritated eye related with the development of the dry eye.5 Dry eye disease diagnosis, classification and severity assessment require multiple evaluations; Schirmer test, tear break-up time (TBUT), ocular surface staining (OSS) with sodium fluorescein,6 and the ocular surface disease index (OSDI) questionnaire are among the more frequently used"

Identification of anthropometric indices that best correlate with insulin sensitivity and insulin resistance from subjects from central Mexico

"Insulin Sensitivity (IS) and Insulin Resistance (IR) mark the development of Type 2 Diabetes. Many reports have demonstrated that anthropometric indices can detect IS and IR, however ethnic variations can influence the optimal cutoff value. Therefore, the aim of this study was to determine the optimal cutoff value for Waist Circumference (WC), Body-Mass Index (BMI), Waist-To-Hip Ratio (WHR), Waist-To-Height Ratio (WHtR), and percent Body Fat (BF %) to determine IS and IR from subjects from central Mexico. Methods: WC, BMI, WHR, WHtR, BF%, fasting plasma glucose, and insulin were determined in 569 subjects (male=286 & females=283; ages: 18-84). IR and IS were determined by the Homeostatic Model Assessment online calculator and Quantitative Insulin Sensitivity Check Index, respectively. The area under the Receiver Operating Characteristic curve (AUC) and Youden´s index for each anthropometric index was calculated to determine its cutoff value. Cutoff value´s efficiency was measured by determining the test´s accuracy"

Índice TG/HDL para identificar a sujetos con síndrome metabólico en población mexicana

"El índice triglicéridos/lipoproteína de alta densidad (TG/HDL) ha sido propuesto como un indicador de riesgo cardiovascular. En México, existe un estudio en adultos jóvenes que lo relaciona con resistencia a la insulina, pero no se ha definido un punto de corte que distinga a sujetos con síndrome metabólico. Objetivo: Determinar el punto de corte para el índice TG/HDL que identifique a sujetos con síndrome metabólico en población mexicana"

Regulación de la ingesta de alimento: una aproximación al sistema endocannabinoide

"El sobrepeso y la obesidad son un problema de salud mundial y su prevalencia continúa en aumento. Se calcula que son 300 millones de adultos obesos y 4 veces más tienen sobrepeso. El panorama para la población infantil tampoco es alentador, si consideramos que 43 millones de niños menores a 5 años son obesos o tienen sobrepeso. La acumulación de grasa corporal puede deberse a un desequilibrio en la compleja interacción de señales químicas entre el sistema nervioso central y tejidos periféricos encargados del control de la conducta alimentaria. Diversos estudios sugieren la participación del sistema endocannabinoide como un regulador clave de la ingesta de alimento. La inhibición farmacológica de los receptores CB1 y la regulación de su expresión a través de la dieta tienen un gran potencial como alternativa para el tratamiento de alteraciones de la conducta alimentaria y de uno de los trastornos más prevalentes, el síndrome metabólico"

Sensibilidad a la insulina y síndrome metabólico

"El Síndrome Metabólico (SM) es considerado un problema de salud pública a nivel mundial. La Diabetes tipo 2 (DT2) y las enfermedades cardiovasculares son dos de las complicaciones del SM que se encuentran dentro de las principales causas de muerte de la población en edad productiva. La comprensión de los mecanismos responsables del inicio y desarrollo del SM permitirá el diagnóstico temprano y el diseño de estrategias de prevención de las complicaciones. Se ha sugerido recientemente que el origen del SM es en realidad la consecuencia de la interacción entre los defectos en la sensibilidad a la insulina y la función de la célula-beta del páncreas endocrino, lo que, a su vez, es un factor condicionante para el desarrollo de las alteraciones metabólicas propias de este síndrome"