1 research outputs found
Variation of PM<sub>2.5</sub> Redox Potential and Toxicity During Monsoon in Delhi, India
This study investigates
daily variations in redox potential of
water- and organic-soluble PM2.5 during Delhi’s
monsoon season, offering insights into its chemical composition, cytotoxicity,
and oxidative threat to various lung conditions. PM2.5 samples,
categorized by pollution levels, showed an average intrinsic oxidative
potential (OPmDTT) of 27.5 pmol min–1 μg–1, OH• generation of 51.1 pmol μg–1, and antioxidant capacity (AOC) in both gallic acid
and trolox equivalency of 62.5 and 35.3 pmol μg–1, respectively. Water-soluble redox-active compounds (RACs) contributed
to approximately 67% of the PM2.5 redox potential. The
polar-phase distribution of RACs in PM2.5 can be modified
by atmospheric photochemistry and precipitation. Biomass burning emerged
as a pivotal pollution source, with polluted PM2.5 samples
exhibiting higher cytotoxicity and oxidative stress in A549 cells.
All PM2.5 compounds impaired cellular respiration, reducing
the oxygen consumption rates in A549 cells. Intrinsic OPmDTT and OH• generation of
PM2.5 were influenced by lung fluid variants, such as exogenous
nicotine and endogenous inflammatory protein. This study provides
a comprehensive perspective on PM2.5 pollution and its
toxicity in Delhi, India during distinct pollution periods and also
points out the importance of considering population disparities and
individual health status in assessing PM2.5 health impacts