5,770 research outputs found
Standard Error of Empirical Bayes Estimate in NONMEM® VI.
The pharmacokinetics/pharmacodynamics analysis software NONMEM® output provides model parameter estimates and associated standard errors. However, the standard error of empirical Bayes estimates of inter-subject variability is not available. A simple and direct method for estimating standard error of the empirical Bayes estimates of inter-subject variability using the NONMEM® VI internal matrix POSTV is developed and applied to several pharmacokinetic models using intensively or sparsely sampled data for demonstration and to evaluate performance. The computed standard error is in general similar to the results from other post-processing methods and the degree of difference, if any, depends on the employed estimation options
Collective resonance modes of Josephson vortices in sandwiched stack of BiSrCaCuO intrinsic Josephson junctions
We observed splitting of the low-bias vortex-flow branch in a
dense-Josephson-vortex state into multiple sub-branches in current-voltage
characteristics of intrinsic Josephson junctions (IJJs) of
BiSrCaCuO single crystals in the long-junction limit.
Each sub-branch corresponds to a plasma mode in serially coupled Josephson
junctions. Splitting into low-bias linear sub-branches with a spread in the
slopes and the inter-sub-branch mode-switching character are in good
quantitative agreement with the prediction of the weak but finite
inter-junction capacitive-coupling model incorporated with the inductive
coupling. This suggests the importance of the role of the capacitive coupling
in accurately describing the vortex dynamics in serially stacked IJJs.Comment: 4 pages, 3 figures, 1 tabl
Hypervector Spaces Based on Intersectional Soft Sets
The notion of int-soft subfields, int-soft algebras over int-soft subfields, and int-soft hypervector spaces are introduced, and their properties and characterizations are considered. In connection with linear transformations, int-soft hypervector spaces are discussed
Radion Dynamics and Phenomenology in the Linear Dilaton Model
We investigate the properties of the radion in the 5D linear dilaton model
arising from Little String Theory. A Goldberger-Wise type mechanism is used to
stabilise a large interbrane distance, with the dilaton now playing the role of
the stabilising field. We consider the coupled fluctuations of the metric and
dilaton fields and identify the physical scalar modes of the system. The
wavefunctions and masses of the radion and Kaluza-Klein modes are calculated,
giving a radion mass of order the curvature scale. As a result of the direct
coupling between the dilaton and Standard Model fields, the radion couples to
the SM Lagrangian, in addition to the trace of the energy-momentum tensor. The
effect of these additional interaction terms on the radion decay modes is
investigated, with a notable increase in the branching fraction to photons. We
also consider the effects of a non-minimal Higgs coupling to gravity, which
introduces a mixing between the Higgs and radion modes. Finally, we calculate
the production cross section of the radion at the LHC and use the current Higgs
searches to place constraints on the parameter space.Comment: 28 pages, 7 figures; v2: error in radion-gauge boson Feynman rules
corrected, version published in JHE
Actin Cytoskeleton and Golgi Involvement in Barley stripe mosaic virus Movement and Cell Wall Localization of Triple Gene Block Proteins.
Barley stripe mosaic virus (BSMV) induces massive actin filament thickening at the infection front of infected Nicotiana benthamiana leaves. To determine the mechanisms leading to actin remodeling, fluorescent protein fusions of the BSMV triple gene block (TGB) proteins were coexpressed in cells with the actin marker DsRed: Talin. TGB ectopic expression experiments revealed that TGB3 is a major elicitor of filament thickening, that TGB2 resulted in formation of intermediate DsRed:Talin filaments, and that TGB1 alone had no obvious effects on actin filament structure. Latrunculin B (LatB) treatments retarded BSMV cell-to-cell movement, disrupted actin filament organization, and dramatically decreased the proportion of paired TGB3 foci appearing at the cell wall (CW). BSMV infection of transgenic plants tagged with GFP-KDEL exhibited membrane proliferation and vesicle formation that were especially evident around the nucleus. Similar membrane proliferation occurred in plants expressing TGB2 and/or TGB3, and DsRed: Talin fluorescence in these plants colocalized with the ER vesicles. TGB3 also associated with the Golgi apparatus and overlapped with cortical vesicles appearing at the cell periphery. Brefeldin A treatments disrupted Golgi and also altered vesicles at the CW, but failed to interfere with TGB CW localization. Our results indicate that actin cytoskeleton interactions are important in BSMV cell-to-cell movement and for CW localization of TGB3
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