Adaptation and initial results of the Polish version of the GA2LEN Chronic Urticaria Quality Of Life Questionnaire (CU-Q2oL)

Background: Strong negative influence upon the quality of life in chronic urticaria is well proved. Before the GA2LEN Chronic Urticaria Quality of Life Questionnaire (CU-Q2oL) was introduced, the quality of life in chronic urticaria had been measured with general or dermatology specific questionnaires. CU-Q2oL was initially developed in Italy and consisted of 23 items divided into 6 quality of life dimensions. Objective: The aim of our study was to adapt the Polish version of CU-Q2oL and to provide initial results from the Polish sample. Methods: To prepare the Polish version forward and back translation was prepared. After cognitive debriefing, we collected a group of 126 chronic urticaria patients who completed Polish CU-Q2oL, Dermatology Life Quality Index (DLQI) and Skindex-29 questionnaire. Disease severity was assessed with Urticaria Activity Score (UAS). We performed the factorial analysis to identify CU-Q2oL subscales in our study, internal consistency and convergent validity assessment as well as factors driving the results. Moreover, we analysed tool's reproducibility and responsiveness. Results: The factor analysis resulted in six subscales of Polish CU-Q2oL version with satisfying face validity: Itching, Swelling/Mental status, Functioning, Sleep, Eating/Limits, Embarrassment. All subscales presented recommended internal consistency and convergent validity. Disease severity was the only factor predicting results of all the subscales. Polish CU-Q2oL version was reproducible and sensitive to change. We noticed the highest quality of life impairment in Itching and Embarrassment subscales whereas Eating/Limits was the least affected. Conclusions: Our study supports reliability, responsiveness and validity of the Polish version of CU-Q2oL - easy in use, non time-consuming instrument to be used in research, clinical management and treatment outcome assessment and is one more step to confirm quality of life impairment in chronic urticaria. © 2011 Japanese Society for Investigative Dermatology