Drugs In the Workplace: A Manager\u27s Guide

Drugs in the workplace is a growing problem that threatens a valuable human resource - the employee. Managers in the hospitality industry can take a proactive stance in meeting the problem head on. The authors discuss what managers can do

MEMRI is a biomarker defining nicotine-specific neuronal responses in subregions of the rodent brain.

Nicotine dependence is defined by dopaminergic neuronal activation within the nucleus accumbens (ACB) and by affected neural projections from nicotine-stimulated neurons. Control of any subsequent neural activities would underpin any smoking cessation strategy. While extensive efforts have been made to study the pathophysiology of nicotine addiction, more limited works were developed to find imaging biomarkers. If such biomarkers are made available, addictive behaviors could be monitored noninvasively. To such ends, we employed manganese (Mn(2+))-enhanced magnetic resonance imaging (MEMRI) to determine whether it could be used to monitor neuronal activities after acute and chronic nicotine exposure in rats. The following were observed. Mn(2+) infusion identified ACB and hippocampal (HIP) neuronal activities following acute nicotine administration. Chronic exposure was achieved by week long subcutaneously implanted nicotine mini-pump. Here nicotine was shown to activate neurons in the ACB, HIP, and the prefrontal and insular cortex. These are all central nervous system reward regions linked to drug addiction. In conclusion, MEMRI is demonstrated to be a powerful imaging tool to study brain subregion specific neuronal activities affected by nicotine. Thus, we posit that MEMRI could be used to assess smoking-associated tolerance, withdrawal and as such serve as a pre-clinical screening tool for addiction cessation strategies in humans

Total Knee Arthroplasty Assessments Should Include Strength and Performance-Based Functional Tests to Complement Range-of-Motion and Patient-Reported Outcome Measures

Range of motion (ROM) and pain often define successful recovery after total knee arthroplasty (TKA), but these routine clinical outcomes correlate poorly or not at all to functional capacity after TKA. The purpose of this Perspective is to underscore the importance of muscle strength and performance-based functional tests in addition to knee ROM and patient-reported outcome (PRO) measures to evaluate outcomes after TKA. Specifically: (1) muscle strength is the rate-limiting step for recovery of function after TKA; (2) progressive rehabilitation targeting early quadriceps muscle strengthening improves outcomes and does not compromise ROM after TKA; (3) ROM and PROs fail to fully capture functional limitations after TKA; and (4) performance-based functional tests are critical to evaluate function objectively after TKA. This Perspective also addresses studies that question the need for or benefit of physical therapy after TKA because their conclusions focus only on ROM and PRO measures. Future research is needed to determine the optimal timing, delivery, intensity, and content of physical therapy

A Foreground Masking Strategy for [CII] Intensity Mapping Experiments Using Galaxies Selected by Stellar Mass and Redshift

Intensity mapping provides a unique means to probe the epoch of reionization (EoR), when the neutral intergalactic medium was ionized by the energetic photons emitted from the first galaxies. The [CII] 158$\mu$m fine-structure line is typically one of the brightest emission lines of star-forming galaxies and thus a promising tracer of the global EoR star-formation activity. However, [CII] intensity maps at $6 \lesssim z \lesssim 8$ are contaminated by interloping CO rotational line emission ($3 \leq J_{\rm upp} \leq 6$) from lower-redshift galaxies. Here we present a strategy to remove the foreground contamination in upcoming [CII] intensity mapping experiments, guided by a model of CO emission from foreground galaxies. The model is based on empirical measurements of the mean and scatter of the total infrared luminosities of galaxies at $z 10^{8}\,\rm M_{\rm \odot}$ selected in $K$-band from the COSMOS/UltraVISTA survey, which can be converted to CO line strengths. For a mock field of the Tomographic Ionized-carbon Mapping Experiment (TIME), we find that masking out the "voxels" (spectral-spatial elements) containing foreground galaxies identified using an optimized CO flux threshold results in a $z$-dependent criterion $m^{\rm AB}_{\rm K} \lesssim 22$ (or $M_{*} \gtrsim 10^{9} \,\rm M_{\rm \odot}$) at $z < 1$ and makes a [CII]/CO$_{\rm tot}$ power ratio of $\gtrsim 10$ at $k=0.1$ $h$/Mpc achievable, at the cost of a moderate $\lesssim 8\%$ loss of total survey volume.Comment: 14 figures, 4 tables, re-submitted to ApJ after addressing reviewer's comments. Comments welcom

Psychosocial Factors and Functional Capacity Evaluation Among Persons with Chronic Pain

Psychosocial factors have been found to have a significant impact on functional activity, particularly among persons with chronic pain. While various systems have been developed to assess functional limitations through functional capacity evaluation (FCE), assessment of psychosocial factors that may impact function have been largely ignored. This paper examines the existing literature on psychosocial factors and FCE performance. Given that there are few studies that have directly addressed this issue, the paper also examines psychosocial factors that have been found to influence function in persons with pain. The results of the literature review indicate that few psychosocial factors have been found to be directly associated with FCE and functional measures, although many are related to various measures of disability. The strongest evidence that psychosocial factors are related to functional performance is based on the studies examining the association between functional activity and pain-related fear, self-efficacy, and illness behavior. Psychosocial factors have also been shown to influence measures of sincerity of effort often obtained during FCE. Proposals for modifying FCE assessment are given based on the available data, as well as suggestions for future research.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45009/1/10926_2004_Article_475080.pd

The time delay of the quadruple quasar RX J0911.4+0551

We present optical lightcurves of the gravitationally lensed components A (=A1+A2+A3) and B of the quadruple quasar RX J0911.4+0551 (z = 2.80). The observations were primarily obtained at the Nordic Optical Telescope between 1997 March and 2001 April and consist of 74 I-band data points for each component. The data allow the measurement of a time delay of 146 +- 8 days (2 sigma) between A and B, with B as the leading component. This value is significantly shorter than that predicted from simple models and indicates a very large external shear. Mass models including the main lens galaxy and the surrounding massive cluster of galaxies at z = 0.77, responsible for the external shear, yield H_0 = 71 +- 4 (random, 2 sigma) +- 8 (systematic) km/s/Mpc. The systematic model uncertainty is governed by the surface-mass density (convergence) at the location of the multiple images.Comment: 12 pages, 3 figures, ApJL, in press (June 20, 2002

Trophic Cascades, Nutrients, and Lake Productivity: Whole-Lake Experiments

Responses of zooplankton, pelagic primary producers, planktonic bacteria, and CO2 exchange with the atmosphere were measured in four lakes with contrasting food webs under a range of nutrient enrichments during a seven-year period. Prior to enrichment, food webs were manipulated to create contrasts between piscivore dominance and planktivore dominance. Nutrient enrichments of inorganic nitrogen and phosphorus exhibited ratios of N:P \u3e 17:1, by atoms, to maintain P limitation. An unmanipulated reference lake, Paul Lake, revealed baseline variability but showed no trends that could confound the interpretation of changes in the nearby manipulated lakes. Herbivorous zooplankton of West Long Lake (piscivorous fishes) were large-bodied Daphnia spp., in contrast to the small-bodied grazers that predominated in Peter Lake (planktivorous fishes). At comparable levels of nutrient enrichment, Peter Lake\u27s areal chlorophyll and areal primary production rates exceeded those of West Long Lake by factors of approximately three and six, respectively. Grazers suppressed pelagic primary producers in West Long Lake, relative to Peter Lake, even when nutrient input rates were so high that soluble reactive phosphorus accumulated in the epilimnions of both lakes during summer. Peter Lake also had higher bacterial production (but not biomass) than West Long Lake. Hydrologic changes that accompanied manipulation of East Long Lake caused concentrations of colored dissolved organic carbon to increase, leading to considerable variability in fish and zooplankton populations. Both trophic cascades and water color appeared to inhibit the response of primary producers to nutrients in East Long Lake. Carbon dioxide was discharged to the atmosphere by Paul Lake in all years and by the other lakes prior to nutrient addition. During nutrient addition, only Peter Lake consistently absorbed CO2 from the atmosphere, due to high rates of carbon fixation by primary producers. In contrast, CO2 concentrations of West Long Lake shifted to near-atmospheric levels, and net fluxes were near zero, while East Long Lake continued to discharge CO2 to the atmosphere

Discovery of Two Gravitationally Lensed Quasars with Image Separations of 3 Arcseconds from the Sloan Digital Sky Survey

We report the discovery of two doubly-imaged quasars, SDSS J100128.61+502756.9 and SDSS J120629.65+433217.6, at redshifts of 1.838 and 1.789 and with image separations of 2.86'' and 2.90'', respectively. The objects were selected as lens candidates from the Sloan Digital Sky Survey (SDSS). Based on the identical nature of the spectra of the two quasars in each pair and the identification of the lens galaxies, we conclude that the objects are gravitational lenses. The lenses are complicated; in both systems there are several galaxies in the fields very close to the quasars, in addition to the lens galaxies themselves. The lens modeling implies that these nearby galaxies contribute significantly to the lens potentials. On larger scales, we have detected an enhancement in the galaxy density near SDSS J100128.61+502756.9. The number of lenses with image separation of ~3'' in the SDSS already exceeds the prediction of simple theoretical models based on the standard Lambda-dominated cosmology and observed velocity function of galaxies.Comment: 24 pages, 9 figures, accepted for publication in Ap