3 year resultes of complex treatment diabetic foot patients

This research presents the experience in treatment of two groups of diabetics (1696 and 246 cases ) with various types of diabetic foot syndrome in podiatric offices as well as specialized surgical settings respectively from 2005 till 2007. The course of diabetes mellitus, peripheral neuropathy along with macroangiopathy ( peripheral arterial disease ), and peculiarities in the course of wound infections in hospitalized diabetics were investigated and evaluated. The basis principle in conservative management as the authors considered was the employment of medicine undergone clinical trials and proven effective in treatment. The surgical procedures included debridements, wide incisions, minor amputations, skin grafting as well as arterializations via a short saphenous vein. The employment of multidisciplinary approach in treatment let save lower limb function in neuropathic and neuroischaemic diabetic foot in 92.4% and 85.6% of cases respectively. It is mandatory to accentuate specialization in the work of podiatric offices, choose patients rationally for timely hospitalization, to use widely revascularization techniques.8 работе представлен опыт лечения пациентов с различными типами синдрома диабетической стопы (СДС) в подиатрическом кабинете (1696 больных) и хирургическом стационаре (246 больных) специализированной службы за период 2005-2007 гг. У пациентов стационара изучена ситуация по течению сахарного диабета, оценены периферическая полинейропатия, макроангиопатия и особенности течения инфекционного процесса. Основным принципом консервативной терапии авторы считали применение препаратов с доказанным влиянием на патологический синдром. Хирургическая тактика включала этапные некрэктомии, широкое вскрытие флегмон, малые ампутации, кожную пластику, а также артериализацию через систему малой подкожной вены. Применение мультидисциплинарного подхода позволило сохранить опорную функцию конечности при нейропатическом типе СДС у 92,4% больных, при нейро-ишемическом — у 85,6%. Для улучшения результатов лечения требуется повышение профильности работы подиатрического кабинета, рациональный отбор пациентов для своевременного лечения в стационаре, широкое применение реваскуляризирующих вмешательств

About Nesting of the Peregrine Falcon on the Water Tower in the Altai Kray, Russia

On 19th of June, 2016 a Peregrine Falcon nestling was found among dwelling houses in Biysk’s neighborhood, reported to us by a local resident E. Shitikova. According to her, the nestling jumped out of the nest on water tower because workers disturbed him. We could examine the tower to find the nest on the 6th of July. The falcons’ nest was found on a partially covered by grass concrete platform on the top of the tower

New data on distribution of Cypripedium macranthon sw. on the territory of Altai krai

The Family Orchidaceae Juss. –occupies an important place among the plants, which were highlighted related to their biology and ecology. The total number of species of the family in the Altai region – 27 (ruberoidny -13, rhizomatous – 14), 10 species of orchids are rare and protected. Among the many flowering plants highlights one of the most beautiful and the most noticeable because of its large flowers Orchid – lady's slipper large-flowered Cypripedium (Cypripedium macranthon Sw.). This species is rare and listed in the regional Red book, as residential landscape areas suffers from collecting in bouquets and digging out the gardeners for the introduction into the culture. Exterminated Orchid in the procurement of herbal raw materials in traditional medicine. The Shoe form a plurality of decorative forms that is of interest to collectors of plants, promotes the collection and implementation in connection with the market demand. Increasing anthropogenic load on the territory of the region, which also adversely affects the number and state of coenopopulations of C. macranthon Sw. For the Altai territory, the modern updated data on the habitat of the Orchid. Four previously unknown local populations of C. macranthon Sw. it is noted in the upper basin of the river Angara in the virgin area

The Anthelmintic Quassinoids Ailanthone and Bruceine a Induce Infertility in the Model Organism Caenorhabditis elegans by an Apoptosis-like Mechanism Induced in Gonadal and Spermathecal Tissues

In continuation of the search for new anthelmintic natural products, the study at hand investigated the nematicidal effects of the two naturally occurring quassinoids ailanthone and bruceine A against the reproductive system of the model nematode 'Caenorhabditis elegans' to pinpoint their anthelmintic mode of action by the application of various microscopic techniques. Differential Interference Contrast (DIC) and the epifluorescence microscopy experiments used in the presented study indicated the genotoxic effects of the tested quassinoids (c ailanthone = 50 µM, c bruceine A = 100 µM) against the nuclei of the investigated gonadal and spermathecal tissues, leaving other morphological key features such as enterocytes or body wall muscle cells unimpaired. In order to gain nanoscopic insight into the morphology of the gonads as well as the considerably smaller spermathecae of 'C. elegans', an innovative protocol of polyethylene glycol embedding, ultra-sectioning, acridine orange staining, tissue identification by epifluorescence, and subsequent AFM-based ultrastructural data acquisition was applied. This sequence allowed the facile and fast assessment of the impact of quassinoid treatment not only on the gonadal but also on the considerably smaller spermathecal tissues of 'C. elegans'. These first-time ultrastructural investigations on 'C. elegans' gonads and spermathecae by AFM led to the identification of specific quassinoid-induced alterations to the nuclei of the reproductive tissues (e.g., highly condensed chromatin, impaired nuclear membrane morphology, as well as altered nucleolus morphology), altogether implying an apoptosis-like effect of ailanthone and bruceine A on the reproductive tissues of 'C. elegans'

Rerults of work of the Raptor Ringing Center of the Russian Raptor Research and Conservation Network in 2014

In work of the Raptor Ringing Center of the Russian Raptor Research and Conservation Network in 2014 participated 39 ornithologists-researchers and birdwatchers who have ringed in total 889 individuals of 23 species of birds of prey (Falconiformers) and owls. From colour marked birds the leaders are Upland Buzzard (Buteo hemilasius) – 154 ind., Eastern Imperial Eagle (Aquila heliaca) – 110 ind., Steppe Eagle (Aquila nipalensis) – 95 ind., Long-Legged Buzzard (Buteo rufinus) – 87 ind., White-Tailed Eagle (Haliaeetus albicilla) – 78ind. For 2014 and the first 5 months of 2015 the information was received about the registration of 50 birds with rings from which 39 birds were identified . Among returns the leaders are Eastern Imperial Eagle (14 ind.) and White-Tailed Eagle (9ind.)