The Centrality of Social-Emotional Learning for Educators during Crisis: The Role of the Principal

Social-emotional learning (SEL) is crucial to human development because SEL helps us maintain supportive relationships and make responsible and caring decisions. This qualitative study aimed at understanding how, if at all, public school educators looked after their social- emotional health in times of crisis, during COVID-19. The sample consisted of 24 educators in three school districts in a Midwestern state of the United States. Findings indicated that participants used several strategies to take care of their emotional health. These strategies included making time for non-school related activities, connecting with colleagues, engaging in small acts of kindness, and providing professional development to equip faculty and staff to manage their anxiety and mental health issues. The relevance of this research is three-fold: (1) At the school’s level, this study supports both teachers and leaders’ well-being and retention. Additionally, this study promotes equity because SEL minded adults help create healthy and safe communities for peers and students; (2) This study sheds light on the best practices to adopt when caring for the social-emotional health of adult educators; and (3) this empirical study contributes to the literature on adult SEL, which is currently limited because the focus of SEL has largely been on and for students

The Viability of Pop-Up Thrift Shops in Increasing Revenues for Goodwill Industries of Akron

The Honors Project in Business Administration course at The University of Akron (UA) College of Business (CoB), conducted September 2021 through May 2022, involved partnership with the local nonprofit Goodwill Industries of Akron (GIA) at the direction of Interim Dean of the CoB, Dr. Susan Hanlon. The purpose of this capstone project was to generate ideas and recommendations to GIA for a new, sustainable business unit, the revenue of which would cover the annual $250,000 operating cost of a new transportation support initiative to overcome GIA’s clients’ barriers to employment. During the secondary research phase of this project undertaken from September 2021 through December 2021, three options for a new business unit were explored: a childcare center business unit; a vocational services and training business unit; and a curated pop-up shop business unit. Ultimately, the latter-most option was chosen as the focus for primary research, as GIA already has high brand recognition for resale goods in the eyes of consumers and operational experience in clothing and accessory sales that they could capitalize on to target a key demographic willing to spend additional monies (found to be called the “creativist” thrift shopper) to sustain a profitable business unit. In this publication, authors Morgan Andrews, Casey Bachowski, Caitlin Croston, Zach Dunphy, and Weston Latham (“Contributor Consultants”) discuss the primary research process which led to arriving at the recommendation that GIA implement a Pop-Up Thrift Shop business unit to increase revenues

The role of oxidative stress in chemical carcinogenesis.

Oxidative stress results when the balance between the production of reactive oxygen species (ROS) overrides the antioxidant capability of the target cell; oxidative damage from the interaction of reactive oxygen with critical cellular macromolecules may occur. ROS may interact with and modify cellular protein, lipid, and DNA, which results in altered target cell function. The accumulation of oxidative damage has been implicated in both acute and chronic cell injury including possible participation in the formation of cancer. Acute oxidative injury may produce selective cell death and a compensatory increase in cell proliferation. This stimulus may result in the formation of newly initiated preneoplastic cells and/or enhance the selective clonal expansion of latent initiated preneoplastic cells. Similarly, sublethal acute oxidative injury may produce unrepaired DNA damage and result in the formation of new mutations and, potentially, new initiated cells. In contrast, sustained chronic oxidative injury may lead to a nonlethal modification of normal cellular growth control mechanisms. Cellular oxidative stress can modify intercellular communication, protein kinase activity, membrane structure and function, and gene expression, and result in modulation of cell growth. We examined the role of oxidative stress as a possible mechanism by which nongenotoxic carcinogens may function. In studies with the selective mouse liver carcinogen dieldrin, a species-specific and dose-dependent decrease in liver antioxidant concentrations with a concomitant increase in ROS formation and oxidative damage was seen. This increase in oxidative stress correlated with an increase in hepatocyte DNA synthesis. Antioxidant supplementation prevented the dieldrin-induced cellular changes. Our findings suggest that the effect of nongenotoxic carcinogens (if they function through oxidative mechanisms) may be amplified in rodents but not in primates because of rodents' greater sensitivity to ROS. These results and findings reported by others support a potential role for oxidative-induced injury in the cancer process specifically during the promotion stage

Circulating Very Small Embryonic-Like Stem Cells in Cardiovascular Disease

Very small embryonic-like cells (VSELs) are a population of stem cells residing in the bone marrow (BM) and several organs, which undergo mobilization into peripheral blood (PB) following acute myocardial infarction and stroke. These cells express markers of pluripotent stem cells (PSCs), such as Oct-4, Nanog, and SSEA-1, as well as early cardiac, endothelial, and neural tissue developmental markers. VSELs can be effectively isolated from the BM, umbilical cord blood, and PB. Peripheral blood and BM-derived VSELs can be expanded in co-culture with C2C12 myoblast feeder layer and undergo differentiation into cells from all three germ layers, including cardiomyocytes and vascular endothelial cells. Isolation of VSLEs using fluorescence-activated cell sorting multiparameter live cell sorting system is dependent on gating strategy based on their small size and expression of PSC and absence of hematopoietic lineage markers. VSELs express early cardiac and endothelial lineages markers (GATA-4, Nkx2.5/Csx, VE-cadherin, and von Willebrand factor), SDF-1 chemokine receptor CXCR4, and undergo rapid mobilization in acute MI and ischemic stroke. Experiments in mice showed differentiation of BM-derived VSELs into cardiac myocytes and effectiveness of expanded and pre-differentiated VSLEs in improvement of left ventricular ejection fraction after myocardial infarction

Developmental and Lactational Exposure to Dieldrin Alters Mammary Tumorigenesis in Her2/neu Transgenic Mice

Breast cancer is the most common cancer in Western women and while its precise etiology is unknown, environmental factors are thought to play a role. The organochlorine pesticide dieldrin is a persistent environmental toxicant thought to increase the risk of breast cancer and reduce survival in the human population. The objective of this study was to define the effect of developmental exposure to environmentally relevant concentrations of dieldrin, on mammary tumor development in the offspring. Sexually mature FVB-MMTV/neu female mice were treated with vehicle (corn oil), or dieldrin (0.45, 2.25, and 4.5 µg/g body weight) daily by gavage for 5 days prior to mating and then once weekly throughout gestation and lactation until weaning. Dieldrin concentrations were selected to produce serum levels representative of human background body burdens, occupational exposure, and overt toxicity. Treatment had no effect on litter size, birth weight or the number of pups surviving to weaning. The highest dose of dieldrin significantly increased the total tumor burden and the volume and number of tumors found in the thoracic mammary glands. Increased mRNA and protein expression of the neurotrophin BDNF and its receptor TrkB was increased in tumors from the offspring of dieldrin treated dams. This study indicates that developmental exposure to the environmental contaminant dieldrin causes increased tumor burden in genetically predisposed mice. Dieldrin exposure also altered the expression of BNDF and TrkB, novel modulators of cancer pathogenesis

Obtaining a license for exploitation of minerals under the new Polish Geological and Mining Law

W artykule omówiono najważniejsze zmiany w zapisach nowej ustawy Prawo geologiczne i górnicze, z dnia 9 czerwca 2011r. ( Dz.U. Nr 163 poz. 981), związane z procesem ubiegania się przedsiębiorcy o koncesję na wydobywanie kopalin. W dziale III ustawy określono zakres wymagań związanych z uzyskaniem koncesji i wyspecyfikowano dokumenty niezbędne do złożenia kompletnego wniosku koncesyjnego. Przytoczono zapisy - ustawy o swobodzie działalności gospodarczej, ustawy z zakresu ochrony środowiska i obszarów Natura 2000 oraz rozporządzenia wykonawcze do tych ustaw, odnoszące się do procedury wydania decyzji o środowiskowych uwarunkowaniach przedsięwzięcia, skompletowania wniosku koncesyjnego i spełnienia wymogów niezbędnych do otrzymania koncesji na wydobywanie kopaliny. Na przykładzie KGHM Polska Miedź S.A., która w latach 2010 - 2013 przeprowadziła proces uzyskania nowych koncesji, dla pięciu złóż na monoklinie przedsudeckiej, zobrazowano skalę trudności procedur formalnych, ilość barier do pokonania i czasochłonność wykonania tej pracy.This paper discusses the most important changes in the provisions of the new Polish Geological and Mining Law of 9 June 2011 - abbreviated in Polish as Pgg (Journal of Laws No. 163, item 981), related with the process of applying for minerals extraction licenses by the mining operators. In chapter III Pgg the set of application requirements necessary to obtain the concessions were determined and documentation to be submitted together with such applications was specified. The paper presents the provisions of the Act on Freedom of Economic Activity (Journal of Laws No. 220, item 1447), laws referring to the environment protection and Natura 2000 areas, regulations enforcing those laws - which refer to the procedure of obtaining the decision on environmental conditions, completion of the license application and procedures of obtaining the license for minerals extraction. The scale of difficulty and level of time-consumption of this process is well presented on the example of KGHM Polish Copper S.A., which in 2010-2013 carried out the process of obtaining new concessions for five deposits in the Foresudetic Monocline

Investigation into the role of oxidative stress in the mechanism of dieldrin hepatotoxicity in the B6C3F1 mouse

This document only includes an excerpt of the corresponding thesis or dissertation. To request a digital scan of the full text, please contact the Ruth Lilly Medical Library's Interlibrary Loan Department ([email protected])