Adsorption of ceftriaxon by biogenic hydroxyapatite with magnetic additions

The possibility of using nanoporous composite system based on biogenic hydroxyapatite (BHA), which alloyed by ferromagnetic additives due to using two methods of physicochemical mixing, as a carrier of drugs for orthopedics and traumatology was shown. It was found that the sample obtained by precipitation previously prepared iron oxalate on the surface of BHA microspheres has a greater adsorption activity than the sample obtained by including BHA directly in the process of obtaining iron oxalate (300 and 175 mg/g respectively). However, due to the difference in porosity, they are capable to hold a different amount of the injected antibiotic mass: 6 mass.% - for material obtained by physico-mechanical method and 10 mass.% - for the sample obtained by chemical method

Some physico-mechanical properties of composite biomaterials on the basis of biogenic hydroxyapatite with magnetic additives

The effect of ferromagnetic additives in the form of magnetite on composite systems based on biogenic hydroxyapatite (BHA) and obtained by physico-mechanical and chemical methods was studied. It was established that the specific density of BHA/Fe₃O₄ powder obtained by physico-mechanical method for introduction of magnetite is close to that of trabecular bone. Herewith, the density of heat-treated pressed samples from this biomaterial is almost equal to that of cortical bone. Experiments in vitro revealed that a decrease in the material bioresorption is bound with a gradual increase in the amount of Ca²⁺ in the filtrates accompanied by a sharp decrease in PO₄⁻³, Fe²⁺ and Fe³⁺ amounts within 5-7 days. The characteristics of elasticity were established to depend on the porosity and chemical composition of samples, decreasing with introduction of ferromagnetic additives that is probably due to the release of thermally induced carbon dioxide while decompositioning of iron oxalates. The results of this study indicate the expediency of using BHA-based biomaterials in orthopedic practice for restoration of bone tissue functions