67 research outputs found

    EBDP BUFFER SIZING STRATEGY 802.11 BASED WLANS

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    In this paper we present wired routers, for whom the sizing of buffers is an active research topic. The classical rule of thumb for sizing wired buffers is to set buffer sizes to be the product of the bandwidth and the average delay of the flows utilizing this link, namely the Bandwidth-Delay Product (BDP) rule. Surprisingly, however the sizing of buffers in wireless networks (especially those based on 802.11/802.11e) appears to have received very little attention within the networking community. Exceptions include the recent work in relating to buffer sizing for voice traffic in 802.11e WLANs, work in which considers the impact of buffer sizing on TCP upload/download fairness, and work in which is related to 802.11e parameter settings

    Java Auto Grader

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    The aim of the project is to develop a “Java Automatic Grader” for java project assignment. It ensures that every assignment or work given to the students is done in the right way. The student should get automatic evaluation after submitting the assignment. We are implementing each test case in such a way that student should only get marks for satisfying all the requirements of the project assignment in fruitful manner i.e. If the student submits the assignment by reaching all the requirements and the expected result is achieved in the right way, then only the student will get full marks

    SIMULTANEOUS DETERMINATION OF ARTESUNATE AND AMODIAQUINE IN HUMAN PLASMA USING LC-MS/MS AND ITS APPLICATION TO A PHARMACOKINETIC STUDY

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    Objective: The objective of this research was to develop a simple, rapid and sensitive liquid chromatography/tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantification of artesunate and amodiaquine in human plasma.Methods: An analytical method based on LC-MS/MS has been developed and validated for the simultaneous determination of artesunate and amodiaquine in human plasma. Isotope-labeled compounds are used as internal standards for the quantification of these drugs. Analytes were extracted from the plasma using solid phase extraction (SPE) technique and chromatographed on a C8 column using an isocratic mobile phase composed of 0.1% ammonia solution and methanol (10:90, v/v). The mobile phase was pumped at a flow rate of 1.00 ml/min. A total of five analytical batches were generated for the calculation of intra-day and inter-day precision and accuracy during the entire course of validation.Results: The assay exhibits excellent linearity in the concentration range of 3.07–305.29 ng/ml for artesunate and 0.30–30.01 ng/ml for amodiaquine. Intra-day and inter-day precision and accuracy results are well within the acceptance limits. All the stability experiments were conducted in plasma samples and in neat samples are complying with the recent US FDA and EMEA guidelines.Conclusion: The proposed LC–MS/MS assay method is simple, rapid and sensitive enough for the simultaneous determination of artesunate and amodiaquine in human plasma. This method was successfully used to quantitate the in-vivo plasma concentrations obtained from a pharmacokinetic study and the results were validated by conducting incurred samples reanalysis (ISR).Â

    THE IMPACT OF SHARE PRICES BEFORE AND AFTER THE DIVIDEND ANNOUNCEMENT WITH REGARD TO BANK NIFTY COMPANIES

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    The purpose of this paper is to examine the relationship between dividend announcement and shareholders value. According to the dividend signalling theory, a company decides to announce its dividend pay-out policy to signal the market that the firm is now processing future prospects, which will result in changing its stock prices

    Common fixed point theorems through generalized altering distance functions

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    In this paper we obtain a unique common fixed point theorem, for four self maps using a generalized altering distance function in four variables , which generalizes and improves the main theorem of Choudhury [2]. We also obtain a Gregus type common fixed point theorem for four maps as a corollary

    Scaling Autoregressive Multi-Modal Models: Pretraining and Instruction Tuning

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    We present CM3Leon (pronounced "Chameleon"), a retrieval-augmented, token-based, decoder-only multi-modal language model capable of generating and infilling both text and images. CM3Leon uses the CM3 multi-modal architecture but additionally shows the extreme benefits of scaling up and tuning on more diverse instruction-style data. It is the first multi-modal model trained with a recipe adapted from text-only language models, including a large-scale retrieval-augmented pre-training stage and a second multi-task supervised fine-tuning (SFT) stage. It is also a general-purpose model that can do both text-to-image and image-to-text generation, allowing us to introduce self-contained contrastive decoding methods that produce high-quality outputs. Extensive experiments demonstrate that this recipe is highly effective for multi-modal models. CM3Leon achieves state-of-the-art performance in text-to-image generation with 5x less training compute than comparable methods (zero-shot MS-COCO FID of 4.88). After SFT, CM3Leon can also demonstrate unprecedented levels of controllability in tasks ranging from language-guided image editing to image-controlled generation and segmentation

    Análise da evolução do índice de bem-estar econômico sustentável modificado no Brasil entre 2004 e 2014.

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    TCC (graduação) - Universidade Federal de Santa Catarina. Centro Sócio-Econômico. Economia.A preocupação com o Meio Ambiente é um assunto cada vez mais abordado na economia. Diversos conceitos de desenvolvimento sustentável e sustentabilidade estão estabelecidos. Juntamente com a evolução dos conceitos, criou-se diversas maneiras de mensurar o desenvolvimento sustentável para tentar explicar o bem-estar de uma maneira mais abrangente que os indicadores convencionais. O IBEESm desenvolveu-se por uma inspiração a partir das mudanças na metodologia dos índices desenvolvidos anteriormente. O objetivo principal deste trabalho é analisar o comportamento do Índice de Bem-Estar Econômico Sustentável Modificado no Brasil no período entre 2004 e 2014 e comparar com os indicadores convencionais, PIB e IDH, para verificar a abrangência de sua explicação na questão do bem-estar econômico sustentável. Primeiramente, o estudo partiu de concepções teóricas documentais referentes ao tema de economia do meio ambiente relacionada à criação de índices de Bem-Estar econômico e sustentável. Realizou-se um levantamento de dados secundários em fontes oficiais e estimou-se empiricamente, por meio da Análise dos Componentes Principais o índice para o Brasil a partir da metodologia construída. A decomposição do índice para análise do comportamento das variáveis dentro das dimensões permitiu avaliar o impacto de cada uma em relação ao bem-estar. Conclui-se, a partir das análises, que o bem-estar econômico sustentável é melhor explicado quando abordadas as suas três dimensões. Conclui-se também que o desmatamento é uma medida importante para o bem-estar no Brasil. Constatou-se, por fim, que os indicadores convencionais não captam todas as mudanças referentes, especialmente, ao meio ambiente

    Genetic Biomarkers for ALS Disease in Transgenic SOD1G93A Mice

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    The pathophysiological mechanisms of both familial and sporadic Amyotrophic Lateral Sclerosis (ALS) are unknown, although growing evidence suggests that skeletal muscle tissue is a primary target of ALS toxicity. Skeletal muscle biopsies were performed on transgenic SOD1G93A mice, a mouse model of ALS, to determine genetic biomarkers of disease longevity. Mice were anesthetized with isoflurane, and three biopsy samples were obtained per animal at the three main stages of the disease. Transcriptional expression levels of seventeen genes, Ankrd1, Calm1, Col19a1, Fbxo32, Gsr, Impa1, Mef2c, Mt2, Myf5, Myod1, Myog, Nnt, Nogo A, Pax7, Rrad, Sln and Snx10, were tested in each muscle biopsy sample. Total RNA was extracted using TRIzol Reagent according to the manufacturer's protocol, and variations in gene expression were assayed by real-time PCR for all of the samples. The Pearson correlation coefficient was used to determine the linear correlation between transcriptional expression levels throughout disease progression and longevity. Consistent with the results obtained from total skeletal muscle of transgenic SOD1G93A mice and 74-day-old denervated mice, five genes (Mef2c, Gsr, Col19a1, Calm1 and Snx10) could be considered potential genetic biomarkers of longevity in transgenic SOD1G93A mice. These results are important because they may lead to the exploration of previously unexamined tissues in the search for new disease biomarkers and even to the application of these findings in human studies

    Robust estimation of bacterial cell count from optical density

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    Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-cost, and highly accessible OD calibration protocols across 244 laboratories, applied to eight strains of constitutive GFP-expressing E. coli. Based on our results, we recommend calibrating OD to estimated cell count using serial dilution of silica microspheres, which produces highly precise calibration (95.5% of residuals <1.2-fold), is easily assessed for quality control, also assesses instrument effective linear range, and can be combined with fluorescence calibration to obtain units of Molecules of Equivalent Fluorescein (MEFL) per cell, allowing direct comparison and data fusion with flow cytometry measurements: in our study, fluorescence per cell measurements showed only a 1.07-fold mean difference between plate reader and flow cytometry data
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