A new bile acid-derived lariat-ether: design, synthesis and cation binding properties

A new chola lariat ether (1, a 21-crown-6) was constructed fromreadily available precursors. The association constant of compound 1 with alkali metal picrates was measured using Cram's extraction protocol. Evidence is presented for the involvement of the 3-methoxy group for the complexation. Energy minimised structures show that the A-ring gets slightly distorted upon metal ion binding

A new bile acid-derived lariat-ether: Design, synthesis and cation binding properties

A new chola lariat ether (1, a 21-crown-6) was constructed from readily available precursors. The association constant of compound 1 with alkali metal picrates was measured using Cram’s extraction protocol. Evidence is presented for the involvement of the 3-methoxy group for the complexation. Energy minimised structures show that the A-ring gets slightly distorted upon metal ion binding

Physicochemical analysis of slip flow phenomena in liquids under nanoscale confinement

Eyring theory employs the statistical mechanical theory of absolute reaction rates to analyse the transport mechanisms in fluids. A physicochemical methodology combining molecular dynamics (MD) and Eyring theory of reaction rates is proposed for investigating the liquid slip on a solid wall in the nanoscale domain. The method involves the determination of activation energy required for the flow process directly from the MD trajectory information and then calculate the important transport properties of the confined fluid from the activation energy. In order to demonstrate the universal applicability of the proposed methodology in nanofluidics, the slip flow behavior of argon, water and ionic liquid confined in various nanostructures has been investigated. The slip length is found to be size dependent in all the cases. The novelty of this method is that the variations in slip length are explained on the basis of molecular interactions and the subsequent changes in the activation energy

A Semi- Blind Reference Watermarking Scheme Using DWT-DCT-SVD for Copyright Protection”,

ABSTRACT In this paper we propose a semi-blind watermarking scheme using Discrete Wavelet Transform an

Helical aggregates from a chiral organogelator

A new class of pyrene based organogelators has been discovered, and a chiral gelator of this type has been shown to form helical aggregates upon gelation

Genetic Architecture, Studies to Identify the Selection Criteria for Yield in Long Duration Rice Lines (Oryza sativa L.)

The current study aimed to explore the genetic variability, narrow sense heritability, genetic advance, Intra and Inter character associations, path coefficient analysis and principal factor - component analysis of yield component traits in long duration varieties of rice. The goal was to identify keynote factor for grain yield promoting, in event on exposure to long duration vegetative phase and engaged in long photosynthetic duration. High heritability and genetic advance, along with strong correlations with yield, were observed for filled grains per panicle and total grains per panicle, suggesting their suitability for direct phenotypic selection to improve these traits. Test weight showed a genuine relationship with grain yield, indicating its effectiveness for direct selection. Principal component analysis noted four components, with eigenvalues higher than 1, explaining 86.5 percent of the total variability. Among these components, the highest variability was attributed to filled grains per panicle and total grains per panicle. Filled grains per panicle is identified with positive direct effect and noted positive significant correlation for the grain yield         per plant, making it an effective selection criterion for improving grain yield in long-duration rice crops

Pyrene-derived novel one- and two-component organogelators

A new class of alkyl-chain-appended pyrene derivatives 4-14 were synthesized and evaluated for their gelation abilities. Depending on the nature of the linking group, these compounds gelated a number of organic solvents, either in the presence or in the absence of the acceptor molecule 2,4,7-trinitrofluorenone (TNF). Compounds with ester, ether, or alkyl linkages gelated a number of hydroxylic and hydrocarbon solvents by means of a charge-transfer interaction with TNF, while compounds with amide, urethane and urea linkers formed gels on their own in a variety of solvents by means of π-π stacking and hydrogen-bonding interactions. The Xray crystal structure of urethane (S)-12 showed hydrogen-bonding and stacking features, as suggested by the model. The gels obtained were investigated by spectroscopic and electron microscopic techniques which provided structural insights

Toxicological data of rats and rabbits: Sub-chronic testing of recombinant HPV vaccine through oral and intranasal routes

Current article illustrates the data of body weight, biochemical, haematological profile, and organ weights of rats and rabbits administered with recombinant human papilloma virus (HPV) vaccine, along with genotoxicity effect. The data was collected from nonclinical safety/toxicity and immune response evaluations of recombinant Salmonella typhi expressing the HPV 16 and 18 L1 proteins as vaccine. The intended clinical route of vaccine administration is through oral route, whereas it is established fact that attenuated S. typhi could not colonize in laboratory animals. In view of this it is challenging to undertake the nonclinical safety/toxicity evaluations following the regulatory guidelines. Hence sub chronic safety/toxicity testing was carried out in rat and rabbits by administration of HPV vaccine through oral (intended clinical route) and innovative intranasal routes.The prophylactic dose derived from adult human clinical dose (2 × 109CFU/70 kg) was administered to SD rats (PD: 0.18 × 109CFU/kg) and New Zealand White (NZW) rabbits (PD: 0.09 × 109CFU/kg) through oral and intranasal routes. Similarly, average dose (AD:5xPD) was administered to rats (AD:0.9 × 109CFU/kg) and rabbits (AD: 0.45 × 109CFU/kg) through intranasal route only. The repeated doses were administered on 3rd and 5th days of post-exposure of 1st dose through specified routes and test compound effects in relation with time of exposure was assessed by euthanizing animals and data collection at different time points i.e. 15th (25% of animals), 29th (25% of animals) and 93rd days (50% of animals) of post-exposure of 1st dose. The retro-orbital plexus blood was collected before euthanizing animals to unveil the biochemical and haematological profile. The data on genotoxicity effect of test compound, if any, was obtained by assessing the bone-marrow micronucleus assay. The immune response and allergenicity in terms of specific IgG and IgE levels against HPV 16 and 18 L1 proteins were determined in mice. The raw data of various parameters collected at different time points were compiled and computed according to the groups. The haematological profile and organ weights data can be used as reference data for SD rats and NZW rabbits for future studies

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Not AvailableInland lentic waterbodies have a major role in contributing to nutritional and livelihood security of the rural poor in India. Generating a spatio-temporal resource inventory of the small waterbodies has immense potential in evidence-based fisheries development planning, so as to enhance the fish production (quantity) and productivity (quantity per unit area). The present study provides a framework for mapping these waterbodies using high resolution Cartosat 1 PAN and IRS ResourceSAT LISS IV merged imagery, determining the spatio-temporal water spread area and effective water spread area available for fish culture using Sentinel 2 Multi Spectral Imagery, for the years 2016–18. It provides an approach for determining the number of fingerlings required and estimating the production potential under standard production parameters, based on the extent of water available for fish culture in the waterbodies. The framework was piloted in Chhattisgarh, a landlocked State in Central India, which has a large number of inland waterbodies. A total of 121,529 waterbodies, with an area of 202,016 ha were mapped, of which 97% had an extent less than 5 ha. The total extent of waterbodies was 37% higher than the most recent estimate by Government of India. Availability of water in the waterbodies of the state, for a duration of at least 8 and 11 months in a year, was found to be 74% (149,484 ha) and 50% (102,167 ha) respectively, which indicates the vast scope for promotion of intensive aquaculture in the state. Minimum number of fingerlings required for stocking the available water was estimated as 403 million. This framework can be replicated across the country and other regions with poor in-situ data, for effective management of inland waterbodies through location-specific data-driven intervention planning