Citoarhitektura humanog paraventrikularnog jedra

Introduction. The significance of this research in terms of structure and biochemical processes in PVN contributes to further understanding of vital physiological processes from delivery and stress to delicate chemical processes that keep the hypothalamo-hypophysial axis in balance. Conclusion. Comparative studies of the human hypothalamus with the hypothalamus of other mammals enable further research, especially pharmacological and physiological ones. These are made possible with the aid of highly sophisticated equipment for examination of neurophysiological features of the brain.Ovim člankom smo želeli da ukažemo na važnost paraventrikularnog jedra pokazujući novije podele ćelijskih podgrupa, kao i podele prema hemijskom sastavu proteina koji se nalaze u njemu. Fiziološka uloga hipotalamo-hipofiznog kompleksa je svakako uslovljena njegovim vezama sa drugim delovima mozga, kao i hemijskim supstancijama od kojih zavisi prenos signala. Uvođenjem savršenijih tehnika u razvojno-neurobiološka istraživanja, možemo da pratimo i poredimo mnoge delove mozga, pa i paraventrikularno jedro s istim jedrima drugih sisara, a time omogućimo lakši rad na eksperimentalnim modelima fiziološko-farmakoloških i drugih istraživanja

HPV testing on self collected cervicovaginal lavage specimens as screening method for women who do not attend cervical screening: cohort study

Objective To determine whether offering self sampling of cervicovaginal material for high risk human papillomavirus (HPV) testing is an effective screening method for women who do not attend regular cervical screening programmes

Molecular Insights in Uterine Leiomyosarcoma: A Systematic Review

Uterine fibroids (UFs) are the most common benign tumors of female genital diseases, unlike uterine leiomyosarcoma (LMS), a rare and aggressive uterine cancer. This narrative review aims to discuss the biology and diagnosis of LMS and, at the same time, their differential diagnosis, in order to distinguish the biological and molecular origins. The authors performed a Medline and PubMed search for the years 1990–2022 using a combination of keywords on the topics to highlight the many genes and proteins involved in the pathogenesis of LMS. The mutation of these genes, in addition to the altered expression and functions of their enzymes, are potentially biomarkers of uterine LMS. Thus, the use of this molecular and protein information could favor differential diagnosis and personalized therapy based on the molecular characteristics of LMS tissue, leading to timely diagnoses and potential better outcomes for patients

Human papillomavirus testing on self-sampled cervicovaginal brushes: An effective alternative to protect nonresponders in cervical screening programs

Women not attending cervical screening programs are at increased risk of cervical cancer. We investigated in these nonresponders to what extent offering self-sampling devices for cervicovaginal brushes for high-risk human papillomavirus (hrHPV) testing would induce participation and, if so, what the yield of precursor (i.e. CIN2 or worse) lesions following self-sampling would be. In addition, we assessed screening history of participants and costs per detected high-grade CIN2 or worse ("CIN2+") lesion in comparison to the regular program in the Netherlands. Nonresponders received a device for hrHPV testing (self-sampling group, n = 2,546) or an extra recall for conventional cytology (control group, n = 284). The percentage of self-sampling responders were compared with responders in the recall group. hrHPV positive self-sampling responders were invited for cytology and colposcopy. CIN2+ yield and costs per detected C1N2+ were evaluated. Active response was higher in the self-sampling than in the control group (34.2 vs. 17.6%; p < 0.001). hrHPV positive self-sampling responders were less likely to have a prior screening history than screening participants (p < 0.001), indicating that they are regular nonresponders. hrHPV prevalence was similar (8.0 vs. 6.8%; p = 0.11), but CIN2+ yield was higher in self-sampling responders compared to screening participants (1.67 vs. 0.97%; OR = 2.93, 95% CI 1.48-5.80; p = 0.0013). Costs per CIN2+ lesion detected via self-sampling were in the same range as those calculated for conventional cytological screening (€8,836 vs. €7,599). Offering self-sampling for hrHPV testing in nonresponders is an attractive adjunct to effectively increase population coverage of screening without the adverse effect of markedly increased costs per detected CIN2+ lesion

Invisible monuments: a handbook for reading the city

Dokumentarna pozorišna predstava o sećanju na Drugi svetski rat, antifašističku borbu i Holokaust u Beogradu. Predstava je nastala u okviru projekta “Dvostruki teret - učenje o nacionalsocijalizmu i Holokaustu u Evropi”. Projekat je podržan od strane Evropske unije.Documentary theatre play about the memory of the Second World War, the anti-fascist struggle and the Holocaust in Belgrade. The performance was created as part of the project "Double Burden - learning about National Socialism and the Holocaust in Europe". The project is supported by the European Union.YouTube link: [https://www.youtube.com/watch?v=0a5Pe8td1k0]Originalna muzika: Attila Antal. Video: Igor Marković. Koreografija: Rada Kovačević. Scenski pokret: Zvonimir Peranić. Asistent režije i saradnik za dikciju i scenski govor: Uroš Novović. Asistentkinja koreografkinje: Natalia Kidišević. Producentkinja: Jovana Janjić. Saradnici/ce na projektu, profesori/ke Treće beogradske gimnazije: Miloš Bajlovski, Biljana Bogojević, Jelena Kručičanin.Stručni saradnici/ce i konsultanti/kinje: Rena Jeremić Raedle, Nenad Lajbenšperger, Ilija Malović, Ana Panić, Tamara Popović, Katarina Pejović, Dubravka Stojanović, Marijana Stojčić, Aleksandar Todosijević.Video dokumentacija: Studio Miroslav.Nosilac projekta: Goethe-Institut Kroatien. Partneri: Documenta - Centar za suočavanje s prošlošću (Zagreb), Forum za primenjenu istoriju (Beograd), Festival tolerancije - Festival suvremenog židovskog filma (Zagreb), Historijski muzej Bosne i Hercegovine (Sarajevo) i zaklada „Stiftung Gedenkstätten Buchenwald und Mittelbau-Dora“ (Weimar). Pridruženi partneri: FKVK Zaprešić, Muzej grada Koprivnice, BITEF teatar (Beograd), Muzej istorije Jugoslavije (Beograd). Škole: Srednja škola „Ban Josip Jelačić“ (Zaprešić), Gimnazija „Obala“ (Sarajevo), Gimnazija „Fran Galović“ (Koprivnica), Gimnazija „Lovassy-László“ (Veszprém) i Treća beogradska gimnazija (Beograd).Trajanje 01:13:40 minuta (duration 01:13:40 minutes)