770 research outputs found
ΠΠ°Π·Π²Π°Π½ΠΈΠ΅ ΡΡΠ°ΡΡΠΈ: ΡΠ½ΠΈΠΆΠ΅Π½ΠΈΠ΅ Π²ΡΠ±ΡΠΎΡΠΎΠ² ΠΏΠ°ΡΠ½ΠΈΠΊΠΎΠ²ΡΡ Π³Π°Π·ΠΎΠ² ΡΠ΅ΡΠ΅Π· ΡΠΏΡΠ°Π²Π»Π΅Π½ΠΈΠ΅ ΠΎΡΡ ΠΎΠ΄Π°ΠΌΠΈ ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π°
Π Π½Π°ΡΡΠΎΡΡΠ΅Π΅ Π²ΡΠ΅ΠΌΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΠ΅ ΠΌΠΈΡΠ° ΡΠ°ΡΡΠ΅Ρ ΠΎΡΠ΅Π½Ρ Π±ΡΡΡΡΠΎ. Π’Π°ΠΊΠΎΠΉ ΡΠΎΡΡ Π½Π°ΡΠ΅Π»Π΅Π½ΠΈΡΡΠΏΠΎΡΠΎΠ±ΡΡΠ²ΡΠ΅Ρ Π²ΡΡΠΎΠΊΠΎΠΌΡ Π·Π°Π³ΡΡΠ·Π½Π΅Π½ΠΈΡ ΠΎΠΊΡΡΠΆΠ°ΡΡΠ΅ΠΉ ΡΡΠ΅Π΄Ρ. Π‘ΠΆΠΈΠ³Π°Π½ΠΈΠ΅ ΡΠ³Π»Π΅Π²ΠΎΠ΄ΠΎΡΠΎΠ΄Π½ΠΎΠ³ΠΎ ΡΠΎΠΏΠ»ΠΈΠ²Π°Π½Π΅ΠΈΠ·Π±Π΅ΠΆΠ½ΠΎ Π²Π΅Π΄Π΅Ρ ΠΊ Π½Π°ΠΊΠΎΠΏΠ»Π΅Π½ΠΈΡ Π² Π°ΡΠΌΠΎΡΡΠ΅ΡΠ΅ ΡΠ³Π»Π΅ΠΊΠΈΡΠ»ΠΎΠ³ΠΎ Π³Π°Π·Π° ΠΈ ΡΡΠΈΠ»Π΅Π½ΠΈΡ ΠΏΠ°ΡΠ½ΠΈΠΊΠΎΠ²ΠΎΠ³ΠΎ ΡΡΡΠ΅ΠΊΡΠ°.Π¦Π΅Π»Ρ ΠΈΡΡΠ»Π΅Π΄ΠΎΠ²Π°Π½ΠΈΡ Π·Π°ΠΊΠ»ΡΡΠ°Π»Π°ΡΡ Π² ΠΎΡΠ΅Π½ΠΊΠ΅ Π²ΠΎΠ·ΠΌΠΎΠΆΠ½ΠΎΡΡΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½ΠΈΡ Π² ΠΏΡΠΎΠΈΠ·Π²ΠΎΠ΄ΡΡΠ²Π΅Π½Π½ΠΎΠΌ ΡΠΈΠΊΠ»Π΅Π²ΡΠΎΡΠΈΡΠ½ΠΎΠΉ ΠΏΠ΅ΡΠ΅ΡΠ°Π±ΠΎΡΠΊΠΈ ΠΈΡΠΏΠΎΠ»ΡΠ·ΠΎΠ²Π°Π½Π½ΡΡ
ΠΠΠ’ Π±ΡΡΡΠ»ΠΎΠΊ ΠΊΠ°ΠΊ Π²Π°ΡΠΈΠ°Π½ΡΠ° ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ ΠΎΡΡ
ΠΎΠ΄ΠΎΠ², ΠΊΠΎΡΠΎΡΡΠΉΠΌΠΎΠΆΠ΅Ρ ΡΡΡΠ΅ΡΡΠ²Π΅Π½Π½ΠΎ ΡΠΌΠ΅Π½ΡΡΠΈΡΡ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈΠ΅ ΠΏΡΠΎΠ±Π»Π΅ΠΌΡ, ΡΠ²ΡΠ·Π°Π½Π½ΡΠ΅ Ρ ΠΎΡΡ
ΠΎΠ΄Π°ΠΌΠΈ ΠΏΠ»Π°ΡΡΠΈΠΊΠΎΠ²ΡΡ
Π±ΡΡΡΠ»ΠΎΠΊ.ΠΠΎΠ»ΠΈΡΠ΅ΡΡΠ²ΠΎ ΠΏΠ°ΡΠ½ΠΈΠΊΠΎΠ²ΡΡ
Π³Π°Π·ΠΎΠ² ΠΌΠΎΠΆΠ΅Ρ Π±ΡΡΡ ΡΠΎΠΊΡΠ°ΡΠ΅Π½ΠΎ Π·Π° ΡΡΠ΅Ρ ΠΎΡΠΊΠ°Π·Π° ΠΎΡ Π·Π°Ρ
ΠΎΡΠΎΠ½Π΅Π½ΠΈΡ ΠΈ ΡΠΆΠΈΠ³Π°Π½ΠΈΡ Π²ΠΏΠΎΠ»ΡΠ·Ρ ΠΏΠ΅ΡΠ΅ΡΠ°Π±ΠΎΡΠΊΠΈ. ΠΠ΅ΡΠ΅ΡΠ°Π±ΠΎΡΠΊΠ° ΡΠ²Π»ΡΠ΅ΡΡΡ ΡΠΊΠΎΠ»ΠΎΠ³ΠΈΡΠ΅ΡΠΊΠΈ Π±ΠΎΠ»Π΅Π΅ ΠΏΡΠ΅Π΄ΠΏΠΎΡΡΠΈΡΠ΅Π»ΡΠ½ΠΎΠΉ Π΄Π»Ρ ΡΡΠΈΠ»ΠΈΠ·Π°ΡΠΈΠΈ ΠΠΠ’ ΠΏΡΠΎΠ΄ΡΠΊΡΠΎΠ²
Visualization of the heart with help of cardiographic equipment
This study presents the problems associated with cardiovascular diseases (CVD) and Twocomponent FitzHugh - Nagumo model and heart condition imaging algorithm are considered. Aspects of work aimed at designing and developing of the hardware and software complex based on the information obtained with the help of an electrocardiograph
Excitation model of cardiac p cells of the cardiac conduction system
The article considers elaboration of the mathematical model of cardiac electrical activity which will allow investigating excitation propagation processes at all sites of the cardiac conduction system. The proposed model is generated on the basis of parametric elements of an electric circuit with distributed parameters and approximation of time dependencies of conduction in ion channels by cubic splines
Two-band superconductors: Extended Ginzburg-Landau formalism by a systematic expansion in small deviation from the critical temperature
We derive the extended Ginzburg-Landau (GL) formalism for a clean s-wave
two-band superconductor by employing a systematic expansion of the free-energy
functional and the corresponding matrix gap equation in powers of the small
deviation from the critical temperature tau = 1-T/T_c. The two lowest orders of
this expansion produce the equation for T_c and the GL theory. It is shown that
in agreement with previous studies, the two-band GL theory maps onto the
single-band GL model and thus fails to describe the difference in the spatial
profiles of the two band condensates. We prove that except for some very
special cases, this difference appears already in the leading correction to the
GL theory, which constitutes the extended GL formalism. We derive linear
differential equations that determine the leading corrections to the band order
parameters and magnetic field, discuss the validity of these equations, and
consider examples of an important interplay between the band condensates.
Finally, we present numerical results for the thermodynamic critical magnetic
field and temperature-dependent band gaps (at zero field), which are in a very
good agreement with those obtained from the full BCS approach in a wide
temperature range. To this end, we emphasize the advantages of our extended GL
theory in comparison with the often used two-component GL-like model based on
an unreconstructed two-band generalization of the Gor'kov derivation
Inhibition of Poly(ADP-Ribose) polymerase enhances the toxicity of 131I-Metaiodobenzylguanidine/Topotecan combination therapy to cells and xenografts that express the noradrenaline transporter
Targeted radiotherapy using [131I]meta-iodobenzylguanidine ([131I]MIBG) has produced remissions in some neuroblastoma patients. We previously reported that combining [131I]MIBG with the topoisomerase I (Topo-I) inhibitor topotecan induced long-term DNA damage and supra-additive toxicity to NAT-expressing cells and xenografts. This combination treatment is undergoing clinical evaluation. This present study investigated the potential of PARP-1 inhibition, in vitro and in vivo, to further enhance [131I]MIBG/topotecan efficacy
Physical degrees of freedom in stabilized brane world models
We consider brane world models with interbrane separation stabilized by the
Goldberger-Wise scalar field. For arbitrary background, or vacuum
configurations of the gravitational and scalar fields in such models, we
construct the second variation Lagrangian, study its gauge invariance, find the
corresponding equations of motion and decouple them in a suitable gauge. We
also derive an effective four-dimensional Lagrangian for such models, which
describes the massless graviton, a tower of massive gravitons and a tower of
massive scalars. It is shown that for a special choice of the background
solution the masses of the graviton excitations may be of the order of a few
TeV, the radion mass of the order of 100 GeV, the inverse size of the extra
dimension being tens of GeV. In this case the coupling of the radion to matter
on the negative tension brane is approximately the same as in the unstabilized
model with the same values of the fundamental five-dimensional energy scale and
the interbrane distance.Comment: 17 pages, LaTeX, corrected typos, amended the normalization constants
of the scalar modes and their coupling constants to matte
Consistency relation for the Lorentz invariant single-field inflation
In this paper we compute the sizes of equilateral and orthogonal shape
bispectrum for the general Lorentz invariant single-field inflation. The
stability of field theory implies a non-negative square of sound speed which
leads to a consistency relation between the sizes of orthogonal and equilateral
shape bispectrum, namely . In
particular, for the single-field Dirac-Born-Infeld (DBI) inflation, the
consistency relation becomes . These consistency relations are also valid in the
mixed scenario where the quantum fluctuations of some other light scalar fields
contribute to a part of total curvature perturbation on the super-horizon scale
and may generate a local form bispectrum. A distinguishing prediction of the
mixed scenario is . Comparing
these consistency relations to WMAP 7yr data, there is still a big room for the
Lorentz invariant inflation, but DBI inflation has been disfavored at more than
68% CL.Comment: 4 pages, 2 figures; v2: title changed, some mistakes corrected; v3:
refs added, version accepted for publication in JCA
On the non-Gaussianity from Recombination
The non-linear effects operating at the recombination epoch generate a
non-Gaussian signal in the CMB anisotropies. Such a contribution is relevant
because it represents a major part of the second-order radiation transfer
function which must be determined in order to have a complete control of both
the primordial and non-primordial part of non-Gaussianity in the CMB
anisotropies. We provide an estimate of the level of non-Gaussianity in the CMB
arising from the recombination epoch which shows up mainly in the equilateral
configuration. We find that it causes a contamination to the possible
measurement of the equilateral primordial bispectrum shifting the minimum
detectable value of the non-Gaussian parameter f^equil_NL by Delta f^equil_NL=
O(10) for an experiment like Planck.Comment: LaTeX file; 11 pages. v2: Typos corrected; references added; comments
about the effective non-linearity parameter added in Sec. IV; comments added
in the conclusions of Sec. IV. v3: References added; some clarifications
added as footnotes 4 and 6, and in Sec. 3. Matches version accepted for
publication in JCA
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