Varying R² and P_SNP cutoffs for the ADRA1 Pathway.

<p>Varying R² and P_SNP cutoffs for the ADRA1 Pathway.</p

Pathway Association Results.

*<p>p-value is significant after correction for multiple testing.</p>†<p>ADRA1, -receptors is the same pathway as ADRA1, with the ADRA1 receptor genes removed from the model.</p><p>Adjustment was made for sex, age, age² and BMI for all models.</p

Line graphs representing the ADRA1 pathway genetic risk model for DBP, SBP, and hypertension (HTN).

<p>The risk score was divided into quintiles, with the reference category being the lowest risk score quintile. * P<0.05. ** P<0.005. ***P<0.0001.</p

Descriptive characteristics of phenotypes among study participants.

<p>Values are expressed as mean±SD.</p

ADRA1 pathway associated genes. Gene names are in italics.

<p>Regulators are in circles. TH, tyrosine hydroxylase; DDC, dopa decarboxylase; DBH, dopamine beta hydroxylase; PNMT, phenylethanolamine N-methyltransferase; ADRA1A, ADRA1B, ADRA1D, adrenergic alpha 1 receptors; GNAQ, guanine nucleotide binding protein, Q; GNA11, guanine nucleotide binding protein, alpha 11; PLCB3, phospholipase C, beta 3; ITPR1, inositol 1,4,5-triphosphate receptor, type 1; POMC, proopiomelanocortin; COMT, catechol-o-methyltransferase; MAO, monoamine oxidase; RGS 2,4,5, regulator of g-protein signaling.</p

Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.

<p>Novel and previously identified BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in African ancestry discovery and replication samples, and European ancestry replication samples.</p

Additional novel BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in sex-stratified analyses of African ancestry discovery and replication samples.

<p>Additional novel BMI and WHR_adjBMI loci at <i>P</i> < 5×10⁻⁸ in sex-stratified analyses of African ancestry discovery and replication samples.</p