Cloth Seals at Iroquois Sites

Textiles represent a very significant component of the Dutch goods that were exported to New Netherland for trade with the Iroquois Indians. These textiles varied greatly in quality. These differences were indicated on lead cloth seals that were affixed to the cloths. The lead cloth seals that are excavated at Iroquois sites provide useful information about the origins and quality of the traded cloth; They also .are a source of information about Dutch textile manufacture in the 17th century, a period during which the cloth industry was the most important urban industry in the Netherlands. Amsterdam was the staple market from , which a,n kinds of textiles from various towns a,:d cities were exported. Amsterdam itselJ was specialized in the dyeing of cloth. A catalogue of the lead cloth seals found at Iroquois and Dutch sites, in New Netherland reveals that. between 1630 and 1670, four Dutch cities were represent~\u27d: Kampen, Leiden, Haarlem, and Amsterdam. There are both round and tubular seals from Kampen. Leiden seals are prima7;ily round. The Amsterdam seals found in Iroquois sites are all seals that verify the quality of the dyeing of the doth. \u27 Haarlem is represented by just one seal, found in Albany, suggesting that cloth from Haarlem was used by the Dutch .colonists themselves, rather than for the trade with the Iroquois. The numbers scratcl:zed on cloth seals indicate cloth lengths. Actual textile fragments excavated at some Iroquois sites represent coarse duffels probably from Kampen as well as finer cloth types probably from Amsterdam. Based on the excavated cloth seals, it can be concluded that most of the cloth fC!r trade with the Iroquois came from Kilmpen

Endometrial stromal cells of women with recurrent miscarriage fail to discriminate between high- and low-quality human embryos

Background The aetiology of recurrent miscarriage (RM) remains largely unexplained. Women with RM have a shorter time to pregnancy interval than normally fertile women, which may be due to more frequent implantation of non-viable embryos. We hypothesized that human endometrial stromal cells (H-EnSCs) of women with RM discriminate less effectively between high-and low-quality human embryos and migrate more readily towards trophoblast spheroids than H-EnSCs of normally fertile women. Methodology/Principal Findings Monolayers of decidualized H-EnSCs were generated from endometrial biopsies of 6 women with RM and 6 fertile controls. Cell-free migration zones were created and the effect of the presence of a high-quality (day 5 blastocyst, n = 13), a low-quality (day 5 blastocyst with three pronuclei or underdeveloped embryo, n = 12) or AC-1M88 trophoblast cell line spheroid on H-ESC migratory activity was analyzed after 18 hours. In the absence of a spheroid or embryo, migration of H-EnSCs from fertile or RM women was similar. In the presence of a low-quality embryo in the zone, the migration of H-EnSCs of control women was inhibited compared to the basal migration in the absence of an embryo (P<0.05) and compared to the migration in the presence of high-quality embryo (p<0.01). Interestingly, the migratory response H-EnSCs of women with RM did not differ between high- and low-quality embryos. Furthermore, in the presence of a spheroid their migration was enhanced compared to the H-EnSCs of controls (p<0.001). Conclusions H-EnSCs of fertile women discriminate between high- and low-quality embryos whereas H-EnSCs of women with RM fail to do so. H-EnSCs of RM women have a higher migratory response to trophoblast spheroids. Future studies will focus on the mechanisms by which low-quality embryos inhibit the migration of H-EnSCs and how this is deregulated in women with RM

General practitioners and referral for palliative radiotherapy: A population-based survey

Background and purpose: The suspicion exists that the referral rate for palliative radiotherapy (RT) is too low. RT, especially in a short series, is an essential and established modality within palliative cancer care for localised symptoms. Material and methods: Questionnaires to evaluate the knowledge of palliative RT were sent to the 1100 general practitioners (GP's) in the area of the Comprehensive Cancer Centre South in the Netherlands, covering about 2.6 million inhabitants. Four hundred and ninety-eight questionnaires were evaluated. Results: Forty-six percent of the respondents had cared for patients referred for palliative RT in the last two years. Knowledge about the effects of palliative RT on bone metastases and spinal cord compression was good but about other palliative indications it was moderate to poor. Determinants of the actual referral for palliative RT were mainly patient related. GPs considered their own knowledge to be poor with only 10% reporting previous RT education. Conclusions: It is absolutely necessary to inform GPs about the possibility of short series of palliative irradiation in order to improve their information for symptomatic cancer patients about all possibilities for palliative treatment. (C) 2009 Elsevier Ireland Ltd. All rights reserved. Radiotherapy and Oncology 91 (2009) 267-27

Towards multi-objective optimization of large-scale fluvial landscaping measures

Adapting densely populated deltas to the combined impacts of climate change and socioeconomic developments presents a major challenge for their sustainable development in the 21st century. Decisions for the adaptations require an overview of cost and benefits and the number of stakeholders involved, which can be used in stakeholder discussions. Therefore, we quantified the trade-offs of common measures to compensate for an increase in discharge and sea level rise on the basis of relevant, but inexhaustive, quantitative variables. We modeled the largest delta distributary of the Rhine River with adaptation scenarios driven by (1) the choice of seven measures, (2) the areas owned by the two largest stakeholders (LS) versus all stakeholders (AS) based on a priori stakeholder preferences, and (3) the ecological or hydraulic design principle. We evaluated measures by their efficiency in flood hazard reduction, potential biodiversity, number of stakeholders as a proxy for governance complexity, and measure implementation cost. We found that only floodplain lowering over the whole study area can offset the altered hydrodynamic boundary conditions; for all other measures, additional dike raising is required. LS areas comprise low hanging fruits for water level lowering due to the governance simplicity and hydraulic efficiency. Natural management of meadows (AS), after roughness smoothing and floodplain lowering, represents the optimum combination between potential biodiversity and flood hazard lowering, as it combines a high potential biodiversity with a relatively low hydrodynamic roughness. With this concept, we step up to a multidisciplinary, quantitative multi-parametric, and multi-objective optimization and support the negotiations among stakeholders in the decision-making process

Towards multi-objective optimization of large-scale fluvial landscaping measures

Adapting densely populated deltas to the combined impacts of climate change and socioeconomic developments presents a major challenge for their sustainable development in the 21st century. Decisions for the adaptations require an overview of cost and benefits and the number of stakeholders involved, which can be used in stakeholder discussions. Therefore, we quantified the trade-offs of common measures to compensate for an increase in discharge and sea level rise on the basis of relevant, but inexhaustive, quantitative variables. We modeled the largest delta distributary of the Rhine River with adaptation scenarios driven by (1) the choice of seven measures, (2) the areas owned by the two largest stakeholders (LS) versus all stakeholders (AS) based on a priori stakeholder preferences, and (3) the ecological or hydraulic design principle. We evaluated measures by their efficiency in flood hazard reduction, potential biodiversity, number of stakeholders as a proxy for governance complexity, and measure implementation cost. We found that only floodplain lowering over the whole study area can offset the altered hydrodynamic boundary conditions; for all other measures, additional dike raising is required. LS areas comprise low hanging fruits for water level lowering due to the governance simplicity and hydraulic efficiency. Natural management of meadows (AS), after roughness smoothing and floodplain lowering, represents the optimum combination between potential biodiversity and flood hazard lowering, as it combines a high potential biodiversity with a relatively low hydrodynamic roughness. With this concept, we step up to a multidisciplinary, quantitative multi-parametric, and multi-objective optimization and support the negotiations among stakeholders in the decision-making process

Confined placental mosaicism and the association with pregnancy outcome and fetal growth: A review of the literature

Background: Chromosomal mosaicism can be detected in different stages of early life: in cleavage stage embryos, in blastocysts and biopsied cells from blastocysts during preimplantation genetic testing for aneuploidies (PGT-A) and later during prenatal testing, as well as after birth in cord blood. Mosaicism at all different stages can be associated with adverse pregnancy outcomes. There is an onward discussion about whether blastocysts diagnosed as chromosomally mosaic by PGT-A should be considered safe for transfer. An accurate diagnosis of mosaicism remains technically challenging and the fate of abnormal cells within an embryo remains largely unknown. However, if aneuploid cells persist in the extraembryonic tissues, they can give rise to confined placental mosaicism (CPM). Non-invasive prenatal testing (NIPT) uses cell-free (cf) DNA released from the placenta in maternal blood, facilitating the detection of CPM. In literature, conflicting evidence is found about whether CPM is associated with fetal growth restriction (FGR) and/or other pregnancy outcomes. This makes counselling for patients by clinicians challenging and more knowledge is needed for clinical decision and policy making. Objective and Rationale: The objective of this review is to evaluate the association between CPM and prenatal growth and adverse pregnancy outcomes. All relevant literature has been reviewed in order to achieve an overview on merged results exploring the relation between CPM and FGR and other adverse pregnancy outcomes. Search Methods: The following Medical Subject Headings (MESH) terms and all their synonyms were used: placental, trophoblast, cytotrophoblast, mosaicism, trisomy, fetal growth, birth weight, small for gestational age and fetal development. A search in Embase, PubMed, Medline Ovid, Web of Science, Cochrane Central Register of Controlled Trials (CENTRAL) and Google Scholar databases was conducted. Relevant articles published until 16 July 2020 were critically analyzed and discussed. Outcomes: There were 823 articles found and screened based on their title/abstract. From these, 213 articles were selected and full text versions were obtained for a second selection, after which 70 publications were included and 328 cases (fetuses) were analyzed. For CPM in eight different chromosomes (of the total 14 analyzed), there was sufficient evidence that birth weight was often below the 5th percentile of fetal growth standards. FGR was reported in 71.7% of CPM cases and preterm birth (<37 weeks of delivery) was reported in 31.0% of cases. A high rate of structural fetal anomalies, 24.2%, in cases with CPM was also identified. High levels of mosaicism in CVS and presence of uniparental disomy (UPD) were significantly associated with adverse pregnancy outcomes. Wider Implications: Based on the literature, the advice to clinicians is to monitor fetal growth intensively from first trimester onwards in case of CPM, especially when chromosome 2, 3, 7, 13, 15, 16 and 22 are involved. In addition to this, it is advised to examine the fetuses thoroughly for structural fetal anomalies and raise awareness of a higher chance of (possibly extreme) premature birth. Despite prematurity in nearly a fifth of cases, the long-term follow-up of CPM life borns seems to be positive. More understanding of the biological mechanisms behind CPM will help in prioritizing embryos for transfer after the detection of mosaicism in embryos through PGT-A

Are serum cobalt and chromium levels predictors for patient-reported outcome measures in the ASR hip resurfacing arthroplasty?

Aims: The aims of this study were to determine if an increasing serum cobalt (Co) and/or chromium (Cr) concentration is correlated with a decreasing Harris Hip Score (HHS) and Hip disability and Osteoarthritis Outcome Score (HOOS) in patients who received the Articular Surface Replacement (ASR) hip resurfacing arthroplasty (HRA), and to evaluate the ten-year revision rate and show if sex, inclination angle, and Co level influenced the revision rate. Methods: A total of 62 patients with an ASR-HRA were included and monitored yearly postoperatively. At follow-up, serum Co and Cr levels were measured and the HHS and the HOOS were scored. In addition, preoperative patient and implant variables and the need for revision surgery were recorded. We used a linear mixed model to relate the serum Co and Cr levels to different patient-reported outcome measures (PROMs). For the survival analyses we used the Kaplan-Meier and Cox regression model. Results: We found that an increase of one part per billion (ppb) in serum Co and Cr levels correlated significantly with worsening of the HHS in the following year. This significant correlation was also true for the HOOS-Pain and HOOS-quality of life sub scores. The overall ten-year survival rate in our cohort was 65% (95% confidence interval (CI) 52.5 to 77.6). Cox regression analysis showed a significant hazard ratio (HR) of 1.08 (95% CI 1.01 to 1.15; p = 0.028) for serum Co level. No significance was found with sex or inclination angle. Conclusion: This study shows that increasing serum Co and Cr levels measured in patients with an ASR-HRA are predictive for deterioration in HHS and HOOS subscales in the following year. Increasing serum Co and Cr should forewarn both surgeon and patient that there is a heightened risk of failure. Continued and regular review of patients with an ASR-HRA implant by measurement of serum Co/Cr levels and PROMs remains essential.</p

Ipsilateral Aorto-Iliac Calcification is Not Directly Associated With eGFR After Kidney Transplantation: A Prospective Cohort Study Analyzed Using a Linear Mixed Model

Aorto-iliac calcification (AIC) is a well-studied risk factor for post-transplant cardiovascular events and mortality. Its effect on graft function remains unknown. The primary aim of this prospective cohort study was to assess the association between AIC and estimated glomerular filtration rate (eGFR) in the first year post-transplant. Eligibility criteria were: ≥50 years of age or ≥30 years with at least one risk factor for vascular disease. A non-contrast-enhanced CT-scan was performed with quantification of AIC using the modified Agatston score. The association between AIC and eGFR was investigated with a linear mixed model adjusted for predefined variables. One-hundred-and-forty patients were included with a median of 31 (interquartile range 26-39) eGFR measurements per patient. No direct association between AIC and eGFR was found. We observed a significant interaction between follow-up time and ipsilateral AIC, indicating that patients with higher AIC scores had lower eGFR trajectory over time starting 100 days after transplant (p = 0.014). To conclude, severe AIC is not directly associated with lower post-transplant eGFR. The significant interaction indicates that patients with more severe AIC have a lower eGFR trajectory after 100 days in the first year post-transplant

Attendance Behavior of Ex-members in Fitness Clubs

The transtheoretical model of behavior change (TTM) is often used to understand and predict health-related behavior. The objective of this study is to apply the TTM’s stages of change to examine patterns of attendance behavior at fitness clubs. A retrospective study was performed to study the later stages of change, using attendance data of members who cancelled their membership in 2012 in two European fitness chains, including 259,355 ex-members of 267 clubs. A sample of 400 was selected at random for analyses, M age = 32.1 yr. (SD = 10.9; 64% males) and 34.7 yr. (SD = 11.0; 51% males) for BasicFit and HealthCity. Regular attendance behavior was defined by at least four visits per month. In the past, all ex-members had purchased a membership and by that were considered to have entered the preparation stage, but 19.5% had never attended the club in 24 months. Of the ex-members, 10% demonstrated regular attendance behavior for six months, and 2.3% had regular attendance for 24 months. 49% did not attend the club for one full month but started regular attendance again. Significant positive correlations were found in attendance behavior between the 6th and 12th months (r = .61), and the 12th and 24th months (r = .45), suggesting that ex-members who attended for more than six months were more likely to have maintained their attendance behavior. With only 10% of the members demonstrating regular attendance behavior, it is evident that appropriate strategies have to be developed to improve attendance behavior and facilitate exercise behavior in fitness clubs