19 research outputs found
Sulfur-Directed Olefin Oxidations: Observation of Divergent Reaction Mechanisms in the Palladium-Mediated Acetoxylation of Unsaturated Thioacetals
The Pd-mediated oxidation of unsaturated thioacetals gives either allyl or vinyl esters, depending on the substrate structure. We report the characterization of a range of sulfur-stabilized palladium intermediates via a combined computational and experimental NMR approach, demonstrating that the oxidation proceeds via two divergent reaction mechanisms. We were also able to synthesize an unusual sigma-bound Pd complex, via acetoxypalladation of an unsaturated dithiane, which was characterized by X-ray crystallography
Chemoenzymatic Dynamic Kinetic Resolution of Primary Amines Using a Recyclable Palladium Nanoparticle Catalyst Together with Lipases
A catalyst consisting of palladium
nanoparticles supported on amino-functionalized
siliceous mesocellular foam (Pd-AmP-MCF) was used in chemoenzymatic
dynamic kinetic resolution (DKR) to convert primary amines to amides
in high yields and excellent ee’s. The efficiency of the nanocatalyst
at temperatures below 70 °C enables reaction conditions that
are more suitable for enzymes. In the present study, this is exemplified
by subjecting 1-phenylethylamine (<b>1a</b>) and analogous benzylic
amines to DKR reactions using two commercially available lipases,
Novozyme-435 (<i>Candida antartica</i> Lipase B) and Amano
Lipase PS-C1 (lipase from <i>Burkholderia cepacia</i>) as
biocatalysts. The latter enzyme has not previously been used in the
DKR of amines because of its low stability at temperatures over 60
°C. The viability of the heterogeneous Pd-AmP-MCF was further
demonstrated in a recycling study, which shows that the catalyst can
be reused up to five times
Efficient Formation of 2,3-Dihydrofurans via Iron-Catalyzed Cycloisomerization of α‑Allenols
Herein, we report a highly efficient
iron-catalyzed intramolecular
nucleophilic cyclization of α-allenols to furnish substituted
2,3-dihydrofurans under mild reaction conditions. A highly diastereoselective
variant of the reaction was developed as well, giving diastereomeric
ratios of up to 98:2. The combination of the iron-catalyzed cycloisomerization
with enzymatic resolution afforded the 2,3-dihydrofuran in high ee.
A detailed DFT study provides insight into the reaction mechanism
and gives a rationalization for the high chemo- and diastereoselectivity