Analytical solution for bending and buckling response of laminated non-homogeneous plates using a simplified-higher order theory

In this study, analytical solutions for the bending and buckling analysis of simply supported laminated non-homogeneous composite plates based on first and simplified-higher order theory are presented. The simplified-higher order theory assumes that the in-plane rotation tensor is constant through the thickness. The constitutive equations of these theories were obtained by using principle of virtual work. Numerical results for the bending response and critical buckling loads of cross-ply laminates are presented. The effect of non-homogeneity, lamination schemes, aspect ratio, side-to-thickness ratio and in-plane orthotropy ratio on the bending and buckling response were analysed. The obtained results are compared with available elasticity and higher order solutions in the literature. The comparison studies show that simplified-higher order theory can achieve the same accuracy of the existing higher order theory for non-homogeneous thin plate

Real-life comparison of the afatinib and first-generation tyrosine kinase inhibitors in nonsmall cell lung cancer harboring EGFR exon 19 deletion: a Turk Oncology Group (TOG) study

Background The new second-generation tyrosine kinase inhibitors (TKIs) have superior survival outcome and worse toxicity profile when compared with first-generation TKIs according to the results of clinical trials. However, there are limited studies that investigate the efficacy and safety of the new generation TKIs in real-world patients. Thus, we aimed to compare the efficacy and safety of the afatinib, an irreversible inhibitor of ErbB family receptor, and first-generation TKIs in real-world patients