Effect of parity on bone mineral density in postmenopausal women

YÖK Tez No: 247192Amaç: Önemli bir halk sağlığı problemi olan osteoporoz için tanımlanmış bir çok risk faktörü bulunmaktadır. Kadınların reprodüktif dönemlerine ait çeşitli özellikleri de osteoporoz gelişimini etkileyebilmektedir. Biz bu çalışmada reprodüktif faktörlerden doğum sayısının postmenapozal osteoporoz gelişimi için bir risk faktörü olup olmadığını araştırmayı amaçladık.Gereç ve Yöntem: Bu çalışma Düzce Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon Polikliniğine başvuran postmenapozal dönemdeki 328 kadın üzerinde gerçekleştirildi. Sekonder osteoporozu ve risk faktörleri olan hastalar çalışmaya dahil edilmedi. Hastalar doğum sayılarına göre hiç doğurmayanlar, 1-2 doğum yapanlar, 3-4 doğum yapanlar ile 5 ve üzeri doğum yapanlar olmak üzere 4 gruba ayrıldı ve kemik mineral yoğunluğu ölçümleri femur boynu ve lomber vertebra (L1-L4) bölgelerinden yapıldı. Çalışmanın istatistiksel analizleri için PASW (sürüm 18) programı kullanıldı.Bulgular: Yapılan değerlendirmeler sonucunda doğum sayısı ile hem femur boynu hem de lomber vertebra kemik mineral yoğunluğu arasında negatif yönde bir korelasyon bulundu (p=0.002, p=0.010, sırasıyla). Hastalar yaş gruplarına göre incelendiğinde doğum sayısı ile kemik mineral yoğunluğu arasında sadece 50-60 yaş grubunda anlamlı bir ilişki tespit edildi (p<0.05). Doğum sayısı ile osteoporotik kırık arasında ise anlamlı bir ilişki saptanmadı (p=0.797).Sonuç: Artmış doğum sayısının kemik mineral yoğunluğunu azaltan bir faktör olduğu bulundu. Postmenapozal dönemdeki kadınlarda osteoporoz için risk faktörleri sorgulanırken doğum sayısının da sorgulanmasıyla osteoporozun erken tanı ve tedavisinin yapılabileceğini düşünmekteyiz. Bu konuyla ilgili yapılan çalışmalardan farklı sonuçların çıkması nedeniyle bu konunun tam aydınlatılabilmesi için yeni çalışmaların yapılması gerektiğini de düşünmekteyiz.Purpose: There have been a lot of risk factors for osteoprosis which is an important communal health problem. A variety of features, belonging to reproductive periods of women can affect the progress of osteoporosis. We have planned to search whether one of the reproductive factors, which is parity, is a risk factor for the progress of postmenopausal osteoporosis or not.Material-Method: This research has been realized on 328 postmenopausal women who have applied to Düzce University, Faculty of Medicine, Physical Medicine and Rehabilitation Polyclinic. Patients, who have secondary osteoporosis and risk factors, have not been included in this research. The patients have been categorized into 4 groups, such as patients who have never given birth, given birth once and twice, three and four times, five times and over. Bone mineral density of the patients have been examined from femoral neck and lomber vertebrae region (L1-L4). PASW programme has been used for the statistical analyses of the research.Results: As a result of the estimations, a negative correlation has been found both in bone mineral density of femoral neck and lomber vertebrae with parity (p=0.002 and p=0.010). When the patients are examined according to their age group, a meaningful relation has been found between parity and bone mineral density only in 50-60 age group. A meaningful relation has not been found between parity and osteoporotic fracture.Conclusion: It has been found that increased parity is a factor, decreasing the bone mineral density. We have concluded that the early detection and treatment of osteoporosis can be realized with the search of the parity, while the risk factors for osteoporosis are being examined on women who are in postmenopausal period. Finally, it has been concluded that since many different results have been concluded from this subject, some new researches must be done so as to enlighten this subject

The Relationship Between Lipid Levels And Bone Mineral Density in Postmenopausal Women

Amaç: Bu çalışmanın amacı postmenapozal kadınlarda lipid düzeyleri ile kemik mineral yoğunluğu arasındaki ilişkiyi araştırmaktır. Yöntem: Çalışmaya Düzce Üniversitesi Tıp Fakültesi Fiziksel Tıp ve Rehabilitasyon AD. polikliniğine başvuran 45-65 yaşları arası (ortalama yaş 54) 276 postmenopozal kadın alındı. Lomber vertebra ve femur boynu kemik mineral yoğunlukları dual enerji X ray absorbsiyometre ile, 12 saat süren açlık sonrası alınan kan örneklerinden serum total kolesterol, lipoproteinler ve trigliserid ölçüldü Çalışmaya hormon replasman ve lipid düzeyi düşürücü tedavi alanlar dahil edilmedi. Çalışmaya alınan tüm kadınlara osteoporoz sorgulama formu dolduruldu. Bulgular: Serum lipoproteinleri, total kolesterol ve trigliserid ile femur boynu ve lomber vertebra kemik mineral yoğunlukları arasında anlamlılık bulunamadı (p0,05). Yüksek vücut kitle indeksi ile femur boynu ve lomber vertebrada yüksek kemik mineral yoğunluğu istatistiksel olarak anlamlı bulundu (p0,001). Sonuç: Postmenopozal kadınlarda kemik mineral yoğunluğu ile lipid düzeyleri arasında istatistiksel olarak anlamlı bir ilişki bulunamadı.Objective: The aim of this study is to investigate the relationship between lipid levels and bone mineral density in postmenopausal women Methods: We studied 276 postmenopausal women aged 45- 65 years (mean 54 years) who attended Duzce University faculty of medicine physical medicine and rehabilitation polyclinic. Bone mineral density in the lumbar spine and femur neck were measured by dual energy X-ray absorptiometry. Serum cholesterol, lipoproteins and triglyceride were assessed on a blood sample obtained after a 12-hour fast. All participants were given a questionnaire to answer on various risk factors for osteoporosis. Participants who reported the use of hormone replacement therapy and lipid lowering therapy were excluded. Statistically significant associations were found by SPSS 11.0 and p0,05) higher body mass index is associated with higher bone mineral density at femur neck and lumbar spine (both p values <0,001). Conclusion: There is no significant relation between bone mineral density and lipid levels in postmenopausal women

Bilateral sakroileit ile birlikte görülen romatoid artrit

Rheumatoid arthritis is an autoimmune disease which is progressive, systemic, chronic, characterized by erosive sinovitis, having unknown etiology and involving joints symmetrically. Rheumatoid arthritis often affects peripheral joints but its axial skeleton involvement is rare. While cervical joints are involved in the vertebral column, sacroiliac joint involvement can be seen rarely. In this case report, a rheumatoid arthritis case with bilateral sacroiliac joint involvement is discussed with differential diagnosis together with the relevant literature. © Turkish Journal of Physical Medicine and Rehabilitation, Published by Galenos Publishing. All rights reserved

Rheumatoid Arthritis Associated with Bilateral Sacroileitis

WOS: 000269581400010Rheumatoid arthritis is an autoimmune disease which is progressive, systemic, chronic, characterized by erosive sinovitis, having unknown etiology and involving joints symmetrically. Rheumatoid arthritis often affects peripheral joints but its axial skeleton involvement is rare. While cervical joints are involved in the vertebral column, sacroiliac joint involvement can be seen rarely. In this case report, a rheumatoid arthritis case with bilateral sacroiliac joint involvement is discussed with differential diagnosis together with the relevant literature. Turk J Phys Med Rehab 2009;55:42-4

Hemophagocytic Syndrome in a Patient with Adult-onset Still's Disease

WOS: 000295972800009Hemophagocytic syndrome is a fatal and life-threatening syndrome characterized by pancytopenia and multiple organ failure. It can frequently be seen in childhood as a primary or familial condition. In adults, it occurs secondarily. In etiology, wide range of factors are related to this syndrome. Adult-onset Still's disease seems to be one of the systemic rheumatological diseases that cause this syndrome. In our literature review, we found few studies related to this syndrome. In this article, we report a 40-year-old female patient who had been treated with the diagnosis of Adult-onset Still's disease for four years in our clinic and who developed hemophagocytic syndrome during her follow-ups

Erkek hastalarda osteoporozun yaşam kali?tesi? üzeri?ne etki?si?ni?n de?erlendi?ri?lmesi?

In previous studies, it has been shown to be the impact of postmenopausal osteoporosis on the patients'quality of life (QOL). The aim of this study was to investigate relationship between osteoporosis and QOL in men with osteoporosis. The study population consisted of 113 men who had osteoporosis and 67 healthy men as control group. Bone mineral density (BMD) was measured by using Dual-Energy X-Ray Absorptiometry (DEXA). The assessment of QOL was carried out using the Short Form 36 (SF- 36) and European Foundation for Osteoporosis (QUALEFFO) scales. The SF- 36 scores were significantly lower in patients with osteoporosis when comparing with controls (61.8 ± 2.7 and 72.7± 2.2, respectively). However, the QUALEFFO scores were significantly higher in men with osteoporosis (58.0 ± 5.1 and 52.0 ± 2.9, respectively). In correlation analysis, the SF- 36 scores positively correlated with femur BMD and spine BMD values (p=0.004, p=0.001, respectively). Moreover, the QUALEFFO scores positively correlated with spine BMD and femur T scores (p=0.001, p=0.011, respectively). Osteoporosis was strongly correlated with worses in QOL assessed by SF- 36 and QUALEFFO scales in men

The effect of parity on bone mineral density in postmenopausal turkish women [Postmenapozal kadinlarda do?um sayisinin kemi?k mi?neral yo?unlu?u üzeri?ne etki?si?]

A lot features, belonging to reproductive periods of women can affect the development of osteoporosis. We have aimed to search whether one of the reproductive factors, which is parity, is a risk factor for the progression of postmenopausal osteoporosis or not. This research has been realized on 328 postmenopausal women who have applied to Physical Medicine and Rehabilitation Polyclinic. Patients, who have secondary osteoporosis and risk factors, have not been included in this research. The patients have been categorized into 4 groups, such as patients who have never given birth, given birth once and twice, three and four times, five times and over. Bone mineral density of the patients have been examined from femoral neck and lomber vertebrae region (L1-L4). As a result of statistical analysis, a negative correlation has been found both in bone mineral density of femoral neck and lomber vertebrae with parity (p=0.002, p=0.010, respectively). When the patients are examined according to their age group, a significant relation has been found between parity and bone mineral density only in 50-60 age group. A significant relation has not been found between parity and osteoporotic fracture. It has been found that increased parity is a factor, decreasing the bone mineral density. We have concluded that the early detection and treatment of osteoporosis can be realized with the search of the parity, while the risk factors for osteoporosis are being examined on women who are in postmenopausal period. Finally, it has been concluded that since many different results have been concluded from this subject, new studies must be done so as to enlighten this subject