A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

Down syndrome, caused by an extra copy of chromosome 21, is associated with a greatly increased risk of early onset Alzheimer disease. It is thought that this risk is conferred by the presence of three copies of the gene encoding amyloid precursor protein (APP), an Alzheimer risk factor, although the possession of extra copies of other chromosome 21 genes may also play a role. Further study of the mechanisms underlying the development of Alzheimer disease in Down syndrome could provide insights into the mechanisms that cause dementia in the general population

Document collections, mobilized regulations, and the making of customary law at the end of the Middle Ages

Using late medieval examples from Switzerland, this paper argues that the emergence of formally organized archives around 1500 was part of an important shift in how documents could be deployed. However, this shift was not away from an oral and toward a literate culture, as argued in some earlier studies, but rather away from seeing documents as testimony that reminded a community about past authoritative actors, and toward relating the texts of documents to other texts, that is, to contexts. This shift took place largely through the appropriation of methods for using and organizing written material that had been developed in the realms of scholastic theology and liturgy, and applying them to secular lordship and administration. These methods provided new models for organizing collections of parchments and papers into connected archives and gave rise to new forms of text collection such as reorganized versions of law books (Spiegel, Coutumiers) containing new search tools such as tables of contents (capitulationes) and indices (abecedaria). Individual charters and scattered legal norms were also organized into textus–glossae structures in larger and smaller administrative units. In the Swiss case, the contextualization of legal texts was accompanied by an increased attribution of authority to ‘custom’ in general, because the community-oriented attribution of meaning found in earlier use was lost. Ultimately, recasting individual documents as part of larger textual contexts increased the power of rulers and ushered in an age of lawyers and of archives

Policy Implications. How to Support Decision-Makers in Setting and Solving Complex Problems

Stakeholders participation in the field of the public decision stimulates learning processes able to generate common knowledge based on shared information. In fact, by including different stakeholders in the decision process different knowledge domains can be integrated. To facilitate this processes, Decision Support Systems (DSSs) have been framed to support stakeholders in decision making for specific purposes. The contribution aims at reflecting on stakeholder participation and to propose a possible participatory process in the context of the location of healthcare facilities based on the methodological framework developed by Simon extended to the scale of Arnstein. Connections of the study within the line of research concerning the “Policy Analytics” perspective are proposed highlighting the importance of the combination of data-driven with value-driven approaches. Moreover, this conclusive chapter will synthetize main achievement and findings of the book