Os objetos epistêmicos das toxoplasmoses e suas reapresentações em um congresso científico internacional The epistemic objects of toxoplasmoses and their re-presentation in an international scientific conference

O artigo investiga os objetos epistêmicos do Toxoplasma gondii e a correlação de forças de grupos de pesquisa empenhados em reconfigurar a toxoplasmose. A pesquisa de dados e a análise foram conduzidas à luz dos conceitos de 'manipulação' e 'reeencenação', com base na ideia de 'dramatização' proposta por Mol em estudo de filosofia empírica. Constatou-se que os objetos foram reapresentados a partir de matizes diversificados e com forte vinculação ao complexo industrial. Por sua projeção nos rumos da economia mundial no século XXI, a genética foi importante protagonista dos debates sobre causalidade única, uma das convicções da ciência ocidental.<br>The paper investigates the epistemic objects of Toxoplasma gondii and the correlation of forces of research groups committed to redefine or reconfigure toxoplasmosis. The data research and this analysis were conducted in a scientific congress, according to the concepts of 'manipulation' and 'reenactment,' based on the idea of 'dramatization' proposed by Mol in a study of empirical philosophy. It was found that the objects were represented from diversified hues and with strong ties to the industrial complex. For its projection in the trends of the global economy in the twenty-first century, genetics was a major protagonist in the debates on sole causality, one of the convictions of Western science

The major genetic determinants of HIV-1 control affect HLA class I peptide presentation.

Infectious and inflammatory diseases have repeatedly shown strong genetic associations within the major histocompatibility complex (MHC); however, the basis for these associations remains elusive. To define host genetic effects on the outcome of a chronic viral infection, we performed genome-wide association analysis in a multiethnic cohort of HIV-1 controllers and progressors, and we analyzed the effects of individual amino acids within the classical human leukocyte antigen (HLA) proteins. We identified &gt;300 genome-wide significant single-nucleotide polymorphisms (SNPs) within the MHC and none elsewhere. Specific amino acids in the HLA-B peptide binding groove, as well as an independent HLA-C effect, explain the SNP associations and reconcile both protective and risk HLA alleles. These results implicate the nature of the HLA-viral peptide interaction as the major factor modulating durable control of HIV infection