Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

Open-angle glaucoma (OAG) is a major cause of blindness worldwide. To identify new risk loci for OAG, we performed a genome-wide association study in 3,071 OAG cases and 6,750 unscreened controls, and meta-analysed the results with GWAS data for intraocular pressure (IOP) and optic disc parameters (the overall meta-analysis sample size varying between 32,000 to 48,000 participants), which are glaucoma-related traits. We identified and independently validated four novel genome-wide significant associations within or near MYOF and CYP26A1, LINC02052 and CRYGS, LMX1B, and LMO7 using single variant tests, one additional locus (C9) using gene-based tests, and two genetic pathways - "response to fluid shear stress" and "abnormal retina morphology" - in pathway-based tests. Interestingly, some of the new risk loci contribute to risk of other genetically-correlated eye diseases including myopia and age-related macular degeneration. To our knowledge, this study is the first integrative study to combine genetic data from OAG and its correlated traits to identify new risk variants and genetic pathways, highlighting the future potential of combining genetic data from genetically-correlated eye traits for the purpose of gene discovery and mapping.Puya Gharahkhani … Robert Casson … et al. [and The NEIGHBORHOOD consortium]

Analysis combining correlated glaucoma traits identifies five new risk loci for open-angle glaucoma

10.1038/s41598-018-20435-9Scientific Reports81312

Ocorrência de Distúrbios Fisiológicos em Manga, var. Tommy Atkins

Procurou-se determinar os fatores da relação planta/ambiente que predispõem frutos da variedade de manga Tommy Atkins a apresentarem distúrbios fisiológicos. Para isso, foram analisados os posicionamentos dos frutos na planta, estádios de maturação e a relação vigor do ramo/fruto. As avaliações permitiram concluir que: a) o posicionamento dos frutos na planta não tem influência alguma na ocorrência das desordens fisiológicas; b) existe certa relação entre vigor dos ramos e a presença dos distúrbios nos frutos; c) o percentual de ocorrência dos distúrbios fisiológicos é altamente influenciado pelo estádio de maturação do fruto à colheita, sendo que, é de pequena monta em frutos colhidos precocemente.<br>Factors of the relation plant/environment which predispose mangoe fruits, var. Tommy Atkins, to physiological disorders were determined. Therefore, fruit location in the plant, the degree of ripeness and the relation of vigor between branch/fruit were analysed. The results allowed the following conclusions: a) the fruit positioning in the plant has no influence on the occurence of physiological disorders; b) there is a certain relation between vigor of the branch and the presence of disorders in the fruit; c) the percentage of occurrence of physiological disorders is a function of the fruit ripeness degree at harvest time, being very small when the fruit is harvested early

Economic importance, breeding objectives and achievements

This chapter reviews the historical context, economic importance, objectives and achievements to-date for many of the more important conifers undergoing domestification throught genetic improvement programs around the world. These provide examples of the context in which genomic technologies will have an impact in forestry. Unlike many other crop plants and livestock animals, forest trees have only been exposed to a few cycles of breeding and selection, and most retain very large amounts of genetic variation in natural populations. These factors present both opportunities and hurdles in the effective application of genomic technologies to existing operational breeding programs

Economic importance, breeding objectives and achievements

This chapter reviews the historical context, economic importance, objectives and achievements to-date for many of the more important conifers undergoing domestification throught genetic improvement programs around the world. These provide examples of the context in which genomic technologies will have an impact in forestry. Unlike many other crop plants and livestock animals, forest trees have only been exposed to a few cycles of breeding and selection, and most retain very large amounts of genetic variation in natural populations. These factors present both opportunities and hurdles in the effective application of genomic technologies to existing operational breeding programs