Transdiagnostic prevention and intervention efforts are needed to address executive dysfunction

Abstract: Executive functioning (EF) is a multi-faceted construct important to activities of daily living, emotion regulation, and higher-order thinking and is often impaired in individuals with gambling disorder and/or alcohol use disorders. Deficits in EF are associated with poor treatment engagement, psychiatric comorbidities, and relapse. The present study examined EF in college students (N = 832) aged 18-24 (M= 19.23, SD=1.37, 76.5% Women) in relation to gambling and hazardous drinking. The Barkley’s Deficits in Executive Functioning was used to assess for global EF and 5 facets of EF: Time Management, Organization/Problem Solving, Self-Restraint, Self-Motivation, and Emotion-Regulation. Bivariate correlation and ANOVA analyses were conducted. Approximately 3% of college students reported problem gambling and 20% reported engagement in hazardous drinking. Compared to individuals with non-problem drinking and non-problem gambling: (1) individuals with problem gambling had worse global EF, self-restraint, emotion regulation, and self-motivation, (2) individuals with hazardous drinking had worse Global EF, self-restraint, and emotion regulation and (3) individuals with both problem gambling and hazardous drinking had worse EF on self-restraint. Implications: Impairments in several domains of EF (e.g., inhibition/self-restraint, emotion regulation, and self-motivation) were endorsed at a significantly higher rate among problematic gamblers and hazardous drinkers. Results partially support the pathways model of gambling (Blaszcynski & Nower, 2002) and support transdiagnostic prevention and intervention efforts around emotion regulation, motivation, and impulsivity

Role of phenol and phosphite antioxidant combinations in the thermal stabilisation of metallocene LLDPE (mLLDPE): Optimisation and performance and influence of metal stearates on multiple extrusions

© 2018 This study progresses our earlier studies and takes the performance characteristics of a 1:1 Irganox 1010: Irgafos 168 combination at 1000 ppm each through multiple extrusion processes in a metallocene LLDPE (mLLDPE) investigating for the first time the role of a broad range of calcium and zinc stearates based on animal vs vegetable origins of the stearine function. In this case performance was assessed using Melt Flow Rate (MFR) coupled with HPLC to determine not only the additive depletions after processing but also the rate of production of the phosphite to phosphonate. Comparative control studies were also undertaken on the single use of the separate antioxidants. Both stearates influenced the activity of the antioxidants in particular their consumption. A greater consumption after the third and fifth extrusion was observed with metal stearates produced from the vegetable stearine. Moreover, zinc stearates seemed to provide a greater detrimental effect than calcium stearates. Hydroperoxide analysis on the stearates confirmed the animal stearine to contain higher levels of peroxides which may contribute toward the higher activity. The optimisation of the thermal stabilisation of the metallocene polyethylene (mLLDPE) has also been investigated in this study. Several conditions of stability were determined for the determination of the optimal antioxidant (phenol:phosphite) ratio. The main parameter was high melt stability for a maximum processing stability of the final package via DSC analysis (OIT) coupled with assessments of embrittlement time (oven ageing) and yellowness index. Long-term stability against thermo-oxidation was considered coupled with a consideration of their hydrolytic stability as a complicating factor. In this work the (phenol/phosphite) antioxidant formulations with two different phenolic antioxidants (Irganox 1010, Irganox 1076) and six different phosphite antioxidants (Irgafos 168, Irgafos P-EPQ, Adekastab PEP-8, Adekastab PEP-36, Adekastab PEP-24G, Adekastab HP-10) were assessed at different levels taking into account the various criteria for optimal performance providing hitherto useful information than many prior studies on 1:1% ratios i.e. how much phosphite is required for optimal activity. A question often posed in the field with the results concluding an interesting unified optimum ratio of 4:1 (for most antioxidants studied) taking into account all the critical parameters

Effect of red clover isoflavones on COX-2 activity in murine and human monocyte/macrophage cells

Long-term use of nonsteroidal anti-inflammatory drugs is associated with a reduction in the incidence of a range of cancers, the mechanism of which is thought to be cyclooxygenase (COX) inhibition. Because long-term ingestion of foods rich in isoflavones, such as legumes (beans, peas, lentils) has been associated with reduced cancer incidence, it was considered useful to examine the COX-inhibitory activities of individual isoflavones. Red clover dietary supplements also contain varying ratios of the 4 isoflavones commonly found in legume-based diets, namely, daidzein, genistein, formononetin, and biochanin. Using 2 separate cell assays, this study examined the ability of the isoflavones found in red clover to inhibit COX enzyme activity in both the murine macrophage cell line RAW 264.7 and human monocytes. Within the range of 1-40 μM in RAW 264.7 cells and 10-100 μM in human monocytes, isoflavones were able to reduce significantly the synthesis of prostaglandin E2 and/or thromboxane B₂ (P < 0.001 to P < 0.05), indicating COX inhibition. Thus, it is possible that the lower rates of some cancers in populations with a high intake of dietary isoflavones is linked to their inhibition of COX activity.Anna N. C. Lam, Maryanne Demasi, Michael J. James, Alan J. Husband, and Catherine Walkerhttp://www.ncbi.nlm.nih.gov/pubmed/1545664