6,455 research outputs found
South African measles outbreak 2009 - 2010 as experienced by a paediatric hospital
Introduction. Between 2009 and 2010, South Africa experienced a major measles outbreak, with more than 18 000 confirmed cases reported to the National Institute of Communicable Diseases.Methods. We studied measles admissions during the outbreak to Red Cross War Memorial Children’s Hospital, Cape Town, between 1 November 2009 and 31 July 2010. Factors associated with mortality were retrospectively identified from notification record  and hospital admissions data. Multivariate logistic regression was used to investigate potential risk factors for death.Results. In total, 1 861 children were diagnosed with measles; 552 (30%) were admitted to hospital. The most common reason for admission was pneumonia (379 (68%)) and/or diarrhoea (262 (48%)). The median age at admission was 7.36 months (interquartile range (IQR) 5.0 - 10.7). The median duration of admission was 4 days (IQR 2 - 6); total hospital admission time was 3 746 days (10.3 child-years). HIV status was known in 404 (73%) children: 39/400 (14%) were HIV-infected. Eighteen children died (3% of all admissions); 15 (83%) of them were less than 1 year old.In the regression model, HIV-infection (adjusted odds ratio (aOR) 7.55, 95% confidence interval (CI) 2.27 - 25.12) and female sex (aOR 3.86, 95% CI 1.26 - 11.84) were associated with higher odds of death.Conclusions. There was a large paediatric admission burden during the 2009 - 2010 measles outbreak in Cape Town; young children were predominantly affected. HIV-infected children had a significantly higher case fatality
Heterotic strings on G_2 orbifolds
We study compactification of heterotic strings to three dimensions on
orbifolds of G_2 holonomy. We consider the standard embedding and show that the
gauge group is broken from E_8 x E_8 or SO(32) to F_4 x E_8 or SO(25)
respectively. We also compute the spectrum of massless states and compare with
the results obtained from reduction of the 10-dimensional fields. Non-standard
embeddings are discussed briefly. For type II compactifications we verify that
IIB and IIA have equal massless spectrum.Comment: LaTex, 21 page
Three-Nucleon Electroweak Capture Reactions
Recent advances in the study of the p-d radiative and mu-3he weak capture
processes are presented and discussed. The three-nucleon bound and scattering
states are obtained using the correlated-hyperspherical-harmonics method, with
realistic Hamiltonians consisting of the Argonne v14 or Argonne v18 two-nucleon
and Tucson-Melbourne or Urbana IX three-nucleon interactions. The
electromagnetic and weak transition operators include one- and two-body
contributions. The theoretical accuracy achieved in these calculations allows
for interesting comparisons with experimental data.Comment: 12 pages, 4 figures, invited talk at the CFIF Fall Workshop: Nuclear
Dynamics, from Quarks to Nuclei, Lisbon, 31st of October - 1st of November
200
Anogenital distance in human male and female newborns: a descriptive, cross-sectional study
BACKGROUND: In animal studies of the effects of hormonally active agents, measurement of anogenital distance (AGD) is now routine, and serves as a bioassay of fetal androgen action. Although measurement of AGD in humans has been discussed in the literature, to our knowledge it has been measured formally in only two descriptive studies of females. Because AGD has been an easy-to-measure, sensitive outcome in animals studies, we developed and implemented an anthropometric protocol for measurement of AGD in human males as well as females. METHODS: We first evaluated the reliability of the AGD measures in 20 subjects. Then measurements were taken on an additional 87 newborns (42 females, 45 males). All subjects were from Morelos, Mexico. RESULTS: The reliability (Pearson r) of the AGD measure was, for females 0.50, and for males, 0.64. The between-subject variation in AGD, however, was much greater than the variation due to measurement error. The AGD measure was about two-fold greater in males (mean, 22 mm) than in females (mean, 11 mm), and there was little overlap in the distributions for males and females. CONCLUSION: The sexual dimorphism of AGD in humans comprises prima facie evidence that this outcome may respond to in utero exposure to hormonally active agents
Inflammatory thresholds and the species-specific effects of colonising bacteria in stable chronic obstructive pulmonary disease
There has been increasing interest in the use of newer, culture-independent techniques to study the airway microbiome of COPD patients. We investigated the relationships between the three common potentially pathogenic microorganisms (PPMs) Haemophilus influenzae, Streptococcus pneumoniae and Moraxella catarrhalis, as detected by quantitative PCR (qPCR), and inflammation and health status in stable patients in the London COPD cohort
Some algorithms to solve a bi-objectives problem for team selection
In real life, many problems are instances of combinatorial optimization. Cross-functional team selection is one of the typical issues. The decision-maker has to select solutions among (kh) solutions in the decision space, where k is the number of all candidates, and h is the number of members in the selected team. This paper is our continuing work since 2018; here, we introduce the completed version of the Min Distance to the Boundary model (MDSB) that allows access to both the "deep" and "wide" aspects of the selected team. The compromise programming approach enables decision-makers to ignore the parameters in the decision-making process. Instead, they point to the one scenario they expect. The aim of model construction focuses on finding the solution that matched the most to the expectation. We develop two algorithms: one is the genetic algorithm and another based on the philosophy of DC programming (DC) and its algorithm (DCA) to find the optimal solution. We also compared the introduced algorithms with the MIQP-CPLEX search algorithm to show their effectiveness
Quantum gravitational contributions to quantum electrodynamics
Quantum electrodynamics describes the interactions of electrons and photons.
Electric charge (the gauge coupling constant) is energy dependent, and there is
a previous claim that charge is affected by gravity (described by general
relativity) with the implication that the charge is reduced at high energies.
But that claim has been very controversial with the situation inconclusive.
Here I report an analysis (free from earlier controversies) demonstrating that
that quantum gravity corrections to quantum electrodynamics have a quadratic
energy dependence that result in the reduction of the electric charge at high
energies, a result known as asymptotic freedom.Comment: To be published in Nature. 19 pages LaTeX, no figure
Axion Protection from Flavor
The QCD axion fails to solve the strong CP problem unless all explicit PQ
violating, Planck-suppressed, dimension n<10 operators are forbidden or have
exponentially small coefficients. We show that all theories with a QCD axion
contain an irreducible source of explicit PQ violation which is proportional to
the determinant of the Yukawa interaction matrix of colored fermions.
Generically, this contribution is of low operator dimension and will
drastically destabilize the axion potential, so its suppression is a necessary
condition for solving the strong CP problem. We propose a mechanism whereby the
PQ symmetry is kept exact up to n=12 with the help of the very same flavor
symmetries which generate the hierarchical quark masses and mixings of the SM.
This "axion flavor protection" is straightforwardly realized in theories which
employ radiative fermion mass generation and grand unification. A universal
feature of this construction is that the heavy quark Yukawa couplings are
generated at the PQ breaking scale.Comment: 16 pages, 2 figure
Theory and Phenomenology of mu in M theory
We consider a solution to the mu-problem within M theory on a G2-manifold.
Our study is based upon the discrete symmetry proposed by Witten that forbids
the mu-term and solves the doublet-triplet splitting problem. We point out that
the symmetry must be broken by moduli stabilization, describing in detail how
this can occur. The mu-term is generated via Kahler interactions after strong
dynamics in the hidden sector generate a potential which stabilizes all moduli
and breaks supersymmetry with m_{3/2} ~ 20 - 30 TeV. We show that mu is
suppressed relative to the gravitino mass, by higher dimensional operators, mu
~ 0.1 m_{3/2} ~ 2-3 TeV. This necessarily gives a Higgsino component to the
(mostly Wino) LSP, and a small but non-negligible LSP-nucleon scattering
cross-section. The maximum, spin-independent cross-sections are not within
reach of the current XENON100 experiment, but are within reach of upcoming runs
and upgrades.Comment: 34 pages, 3 figure
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